PTEN frameshift mutation in two atypical meningiomas: case reports and review of the literature [0.03%]
PTEN错义突变在两例非典型脑膜瘤中的研究及文献复习
Neşe Yeldir,Alican Tahta,Aslı Çakır et al.
Neşe Yeldir et al.
The role of rapid IHC in elevating STAS diagnostic accuracy during intraoperative frozen section for lung adenocarcinoma [0.03%]
快速免疫组化在肺腺癌术中冷冻切片低级别微侵袭诊断中的作用研究
Jialin Lu,Liyan Zhang,Shengnan Zhao et al.
Jialin Lu et al.
Aim: The aim of this study was to evaluate whether the utility of cytokeratin (AE1/AE3) rapid immunohistochemistry (IHC) in combination with haematoxylin-eosin (H&E) staining improves the intraoperative diagnosis of sprea...
PAX8-positive conventional urothelial carcinomas of the urinary bladder and their distinct molecular profiles - A clinicopathologic study of 101 consecutive cases with next-generation sequencing in 20 cases [0.03%]
PAX8阳性的膀胱尿路上皮癌及其独特的分子特征-连续101例的临床病理研究及其中20例行高通量测序分析
Sarah Mae Lammert,Wendy Luo,Allen C Zhu et al.
Sarah Mae Lammert et al.
Aims: PAX8 immunohistochemistry (IHC) is often used to distinguish urothelial carcinomas (UCs) from tumours of renal and Mullerian origin. However, some UCs have been shown to be PAX8-positive. This study investigates the...
Making sense of TILs: recommendations for morphological assessment of tumour-infiltrating lymphocytes in gastro-oesophageal carcinoma: A report on behalf of the International Immuno-Oncology Biomarker Working Group [0.03%]
TILs的来龙去脉：国际免疫肿瘤生物标志物工作组关于胃食管癌瘤内淋巴细胞形态学评估的建议报告
Ylva A Weeda,Roberto Salgado,Filip van Herpe et al.
Ylva A Weeda et al.
In the era of immune checkpoint inhibitors for cancers, the need for prognostic biomarkers to identify patients most likely to achieve a durable response has become increasingly more relevant. Tumour-infiltrating lymphocytes (TILs) have gai...
Despite simplified diagnostic criteria, intraobserver and interobserver variability remain in the interpretation of colorectal serrated polyps [0.03%]
尽管绒毛状息肉的诊断标准已经简化，其解读仍然存在组内和组间差异性
Adam L Booth,Emina E Torlakovic,Runjan Chetty et al.
Adam L Booth et al.
Aims: Many studies have highlighted interobserver variability in histologic distinction between colorectal sessile serrated lesion (SSL) and hyperplastic polyp (HP). In 2019, the WHO updated their criteria for the diagnos...
Molecular pathology of phyllodes tumours of the breast-much more than MED12 [0.03%]
乳腺叶状肿瘤的分子病理学-远不止MED12基因变异
Jia-Min B Pang,Kylie L Gorringe,Puay Hoon Tan et al.
Jia-Min B Pang et al.
Phyllodes tumours of the breast present challenges in their diagnosis, classification and management. Further understanding of the molecular changes underpinning these tumours may lead to more precise classification and potential treatment ...
Aquaporin-1 differentiates intrahepatic cholangiocarcinoma from liver metastases of pancreatic ductal adenocarcinoma [0.03%]
水通道蛋白-1用于区分肝内胆管癌和胰腺导管腺癌肝转移灶
Leoncini Giuseppe,Barella Marco,Droz Dit Busset Michele et al.
Leoncini Giuseppe et al.
Aims: Differentiating intrahepatic cholangiocarcinoma (iCCA) from metastatic ductal adenocarcinoma of the pancreas (mPDAC) is challenging due to commonalities in histology and phenotype. Currently, available biomarkers ar...
Malignant vascular neoplasms of the distal female genital tract: a series of 19 cases emphasizing unusual features and diagnostic challenges [0.03%]
女性生殖道远端恶性血管肿瘤：19例罕见特征及诊断困难的病例分析
Aarti E Sharma,Nicolas Wyvekens,Grace Neville et al.
Aarti E Sharma et al.
Aims: Scarce literature exists regarding the spectrum of vascular neoplasms of the distal female genital tract. Herein, we describe the clinicopathologic features of a cohort of intermediate to malignant endothelial neopl...
"Horses out of the barn": pancreatic ductal adenocarcinoma frequently extends beyond the grossly visible tumour, requiring microscopic rectification for accurate T-staging [0.03%]
“马儿跑出了马厩”：胰腺导管腺癌常超出肉眼可见的肿瘤范围，需要进行显微镜下修正以实现准确的T期分期
Burcu Saka,Bahar Memis,Serdar Balci et al.
Burcu Saka et al.
Aims: Accurate determination of tumour size is critical for pT staging in pancreatic ductal adenocarcinoma (PDAC), yet gross measurement alone often underestimates the true tumour extent because of the tumour's ill-define...
Cutaneous plasmablastic lymphoma: retrospective comparative study of primary and secondary skin involvement [0.03%]
皮肤浆细胞样淋巴瘤：原发性和继发性病例的回顾性比较研究
Federico Repetto,Kristine M Cornejo,Patrick O&#x;Donnell et al.
Federico Repetto et al.
Aims: Cutaneous plasmablastic lymphoma (cPBL) is a rare and aggressive neoplasm that presents as skin nodules. Despite occurring in ~5% of PBL cases, the World Health Organization (WHO) does not distinguish primary cutane...