Quantitative Imaging Analysis of Internal Structural Complexity in Mouse Heart Organoids; Comparison to Mouse Embryonic Hearts [0.03%]
小鼠心脏器官体内的结构复杂性定量成像分析；与小鼠胚胎心脏的比较
Rin Kaneko,Fumitoshi Ishino,Jiyoung Lee
Rin Kaneko
We have established mouse heart organoids (mHOs) that are characterized by the presence of atrium- and ventricle-like structures that mimic entire embryonic hearts. However, maturation was not uniform, and little is known about their trabec...
The TAP/NXF1-Binding Region of HuD Is Required for Translation and Neuronal Differentiation [0.03%]
TAP/NXF1结合区对于HuD调控翻译和神经元分化是必需的
So Toshima,Ryosuke Satoh,Takumi Tomohiro et al.
So Toshima et al.
The neuronal ELAV protein HuD is known to promote neuronal differentiation and stimulate cap-dependent translation, but the underlying mechanism remains incompletely understood. Here, we identify a functional domain within the HuD linker th...
Decreased Mitochondrial Translation Suppresses 3,3'-Diindolylmethane-Induced Reactive Oxygen Species Generation in Schizosaccharomyces Pombe [0.03%]
线粒体翻译减少可抑制3,3'-二吲哚甲烷诱导的裂殖酵母活性氧生成
Kaiyu Wang,Hidenori Osawa,Hideto Nagai et al.
Kaiyu Wang et al.
Broccoli-derived 3,3'-diindolylmethane (DIM) exhibits anticancer effects. The compound also inhibits the growth of fission yeast cells. Reduction of mitochondrial translation alleviates the growth defects caused by DIM in fission yeast; how...
m6A RNA Modification Controls HTLV-1 Tax and Host Gene Expression [0.03%]
M6A RNA修饰调控HTLV-1 TAX及宿主基因表达
Rei Gibu,Kodai Gibu,Kako Suzuki et al.
Rei Gibu et al.
Human T-cell Leukemia Virus Type 1 (HTLV-1) is a pathogenic human retrovirus that is responsible for intractable diseases such as adult T-cell leukemia-lymphoma (ATL), a malignancy with a poor patient prognosis. Although recent studies have...
Knockdown of Cav2.2 Calcium Channel in Macrophages Aggravates Colitis Induced by Dextran Sodium Sulfate [0.03%]
在巨噬细胞中敲低Cav2.2钙通道可加重葡聚糖硫酸钠诱导的结肠炎
Hironao Saegusa,Xiaoxu Li,Xinshuang Wang et al.
Hironao Saegusa et al.
Voltage-dependent calcium channels (VDCCs) have previously been thought to be functional in excitable cells, but recently accumulating evidence suggests that they are also functional in non-excitable cells such as microglia. In the present ...
Machine Learning Extracts Radiation Resistant-Specific EdU Fluorescence Pattern in Cancer Cells [0.03%]
机器学习提取癌细胞中放射抵抗特异的EdU荧光模式
Masae Ikura,Tsuyoshi Ikura,Kanji Furuya
Masae Ikura
The thymidine analog EdU (5-ethynyl-2-deoxyuridine) is incorporated into DNA during replication and has traditionally been used as a marker of S-phase cells. In this study, we discovered that EdU fluorescence images display substantial cell...
Transcriptional Regulation of the Interferon Alpha-Inducible Protein-27 Like 2b by the Peroxisome Proliferator-Activated Receptor γ in Fatty Liver Disease [0.03%]
过氧化物酶体增殖激活受体γ在脂肪性肝病中调控干扰素诱导蛋白27样2b的转录
Ai Sakaguchi,Daisuke Aibara,Kimihiko Matsusue
Ai Sakaguchi
Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor abundantly expressed in the fatty liver of type 2 diabetic ob/ob mice. Herein, we investigated how PPARγ regulates the expression of the interferon alpha-inducibl...
Staphylococcal γ-Hemolysin AB and γ-Hemolysin CB Differentially Activate Murine Bone Marrow-Derived Mast Cells [0.03%]
金黄色葡萄球菌γ-溶血素AB和CB对小鼠骨髓源性肥大细胞的激活作用不同
Hikaru Inoue,Haruka Sakakibara,Shion Kamada et al.
Hikaru Inoue et al.
Staphylococcus aureus (S. aureus) produces various bicomponent pore-forming toxins (PFTs), including the γ-hemolysins (HlgAB and HlgCB) and leukocidins (LukAB and LukED). This study aimed to examine the effect of PFTs on murine bone marrow...