Effects of Dual Inhibition of VEGF-A and Angpt-2 on Angiogenesis and Lymphangiogenesis in an Alkali-Induced Corneal Injury Model [0.03%]
双靶向抑制VEGF-A和Angpt-2对碱烧角膜创面新生血管及淋巴管的联合效应研究
Hiroshi Kuribayashi,Toshiro Iwagawa,Souta Kadohara et al.
Hiroshi Kuribayashi et al.
Corneal neovascularization (CNV) is frequently observed after various corneal injuries and corneal transplantation, leading to impairment of corneal transparency. Lymphangiogenesis and the inflammatory response often accompany CNV. Chemical...
Effects of VEGFA and ANGPT2 Antibodies on the Activation of Microglia in the Early Stages of Streptozotocin-Induced Pathogenesis of Diabetic Retinopathy [0.03%]
VEGFA和ANGPT2抗体对链脲佐菌素诱导的糖尿病视网膜病变早期微胶质细胞活化的影响
Toshiro Iwagawa,Yuta Inokuchi,Kosuke Saita et al.
Toshiro Iwagawa et al.
Diabetic retinopathy (DR) is known as a microvascular complication, in which various inflammatory symptoms, including activation of microglia, are observed. A model of hyperglycemia resembling type 1 diabetes mellitus (DM) induced in mice b...
Functional Analysis of Adhesion GPCR Latrophilin 2 (ADGRL2) in MDA-MB-231 Human Breast Cancer Cells [0.03%]
ADGRL2在MDA-MB-231人乳腺癌细胞中的功能分析研究
Sarmoko,Manami Toriyama,Noriko Kaji et al.
Sarmoko et al.
The tumor microenvironment strongly influences cancer cell behavior, including growth, migration, invasiveness, and gene expression dynamics. Adhesion G protein-coupled receptors (aGPCR) play critical roles in cell-cell or cell-extracellula...
Long Noncoding RNA CCDC26 Interacts With Vimentin, HNRNPC, CBX1, and CBX5 Proteins in Multiple Intracellular Compartments of Myeloid Leukemia Cells [0.03%]
长非编码RNA CCDC26与血管细胞粘附分子-1在髓系白血病细胞多个细胞器内的相互作用
Yuka Tanaka,Atsuhiko Ishida,Hironori Harada et al.
Yuka Tanaka et al.
Long noncoding RNAs (lncRNAs) are involved in various biological events. Previously we reported that lncRNA CCDC26 controls myeloid leukemia cell proliferation and mortality by regulating the proto-oncogene KIT. However, the mechanism of ln...
RNF213-Dependent EGFR and HER2 Activation Regulates Specific Downstream Signaling Pathways in Human Cancer Cells [0.03%]
RNF213依赖的EGFR和HER2活化调节人类癌细胞中的特定下游信号通路
Intisar M Fouad,Jungmi Choi,Qianying Huang et al.
Intisar M Fouad et al.
In this study, we reveal a novel relationship between RNF213, an E3 ubiquitin ligase associated with Moyamoya disease (MMD) and the ubiquitination of both endogenous and pathogenic substrates, and EGFR, the epithelial growth factor receptor...
Microenvironment-Dependent MSC Immunoregulation in Type 1 Diabetes: Insights From IFNγ Preconditioning [0.03%]
干扰素预处理影响胰岛微环境依赖的间充质干细胞免疫调节机制探究——兼论I型糖尿病治疗中的应用探索
Seyed Mehdi Hoseini,Farnoosh Moghimi,Elham Sadat Hosseini et al.
Seyed Mehdi Hoseini et al.
Interferon-gamma (IFNγ) plays a crucial role in the pathogenesis of type 1 diabetes (T1D) and is widely utilized to license mesenchymal stem/stromal cells (MSCs) to enhance their immunosuppressive properties through a process known as prec...
Aqueous Two-Phase System (ATPS)-Based Spore Isolation in Schizosaccharomyces pombe Requires Isp3-Dependent Surface Hydrophobicity [0.03%]
酿酒酵母中基于水相分离体系(SPS)的孢子隔离需要Isp3依赖型表面疏水性
Kazuki Imada
Kazuki Imada
The fission yeast Schizosaccharomyces pombe is a valuable unicellular model organism that proliferates predominantly in the haploid state. Under nitrogen starvation, sexual reproduction occurs, resulting in the formation of a diploid zygote...
PRMT4/CARM1 Is a Novel Factor Promoting DNA Double-Strand Break Repair [0.03%]
一种新的促进DNA双链断裂修复因子PRMT4/CARM1
Yurina Abe,Hayaki Ikegame,Yuina Tsuchiya et al.
Yurina Abe et al.
DNA double-strand breaks (DSBs), among the most deleterious forms of DNA damage, are primarily repaired by non-homologous end-joining or homologous recombination repair in mammalian cells. Although DSB repair is regulated by various posttra...
Generation of Odorant Receptor-QF2 Knock-In Drivers for Improved Analysis of Olfactory Circuits in Drosophila [0.03%]
用于改善果蝇嗅觉环路分析的气味受体-QF2敲入驱动子的生成
Yumiko Ukita,Ryoka Suzuki,Keita Miyoshi et al.
Yumiko Ukita et al.
Drosophila melanogaster has provided numerous insights into the olfactory system, primarily relying on a series of transgenic Gal4 drivers. The combined use of Gal4/UAS and a second binary expression system, such as the QF/QUAS system, prov...
Dissection of Behavioral Components and the Role of Omega/Delta Turns for the Chemotaxis of C. elegans [0.03%]
C. elegans化学趋化性中行为组份的分析及Omega/Delta转向的作用
Karin Suwazono,Koyo Kuze,Ukyo T Tazawa et al.
Karin Suwazono et al.
The chemotactic mechanism of the nematode Caenorhabditis elegans primarily consists of two components: the pirouette mechanism and the weathervane mechanism. The pirouette mechanism is a form of klinokinesis that regulates the frequency of ...