Staphylococcal γ-Hemolysin AB and γ-Hemolysin CB Differentially Activate Murine Bone Marrow-Derived Mast Cells [0.03%]
金黄色葡萄球菌γ-溶血素AB和CB对小鼠骨髓源性肥大细胞的激活作用不同
Hikaru Inoue,Haruka Sakakibara,Shion Kamada et al.
Hikaru Inoue et al.
Staphylococcus aureus (S. aureus) produces various bicomponent pore-forming toxins (PFTs), including the γ-hemolysins (HlgAB and HlgCB) and leukocidins (LukAB and LukED). This study aimed to examine the effect of PFTs on murine bone marrow...
Loss of Nuclear Protein Dyro Causes Abnormalities in Nurse Cell Nuclei and Abort Oogenesis at Mid-Oogenesis Checkpoint [0.03%]
Dyro核蛋白的丧失导致护士细胞异常及卵生成中期检验点失败
Takamoto Shima,Yuuki Kawabata,Yoshimasa Yagi
Takamoto Shima
The mid-oogenesis checkpoint in Drosophila melanogaster functions to optimize nutrient usage by triggering abortion of oogenesis when females are starved or when developmental defects arise in the egg chamber. In the Dyro mutant, which enco...
Maturation Status of Rat Lung Epithelial Cells in Interspecies Chimeras Generated by Blastocyst Complementation [0.03%]
通过囊胚补偿技术产生跨物种嵌合体中胎鼠肺上皮细胞的成熟状态研究
Yamato Murata,Shunsuke Yuri,Masahito Ikawa et al.
Yamato Murata et al.
This study investigates the maturation status of rat lung epithelial cells in interspecies chimeras generated via blastocyst complementation (BC) using Fgfr2b-knockout mouse embryos. In our previous study, we succeeded in generating rat-der...
Functional and Structural Insights Into Complex Formation Between OPTN Leucine Zipper Domain and RAB8A [0.03%]
OPTN亮氨酸拉链结构域与RAB8A复合物的组成机制及作用功能探究
Kei Okatsu,Reika Kikuchi,Noriyuki Matsuda et al.
Kei Okatsu et al.
Optineurin (OPTN) is a multifunctional adaptor protein involved in vesicular trafficking and selective autophagy. In this study, we investigated the molecular mechanism by which OPTN regulates these distinct processes through the leucine zi...
Paralog-Dependent Specialization of Paf1C Subunit, Ctr9, for Sex Chromosome Gene Regulation and Male Germline Differentiation in Drosophila [0.03%]
果蝇中Paf1C亚基Ctr9的旁系同源物依赖性专业化以调节性染色体基因和雄性生殖细胞分化
Toshie Kai,Jinglan Zheng,Taichiro Iki
Toshie Kai
Testis-specific gene regulatory mechanisms govern the differentiation of germ cells into mature sperm. However, the molecular underpinnings are not fully elucidated. Here, we show the subunits forming Paf1C, a transcription regulator comple...
The Meeting Report on the Fifth International Conference of the Chromosomal SMC Complexes [0.03%]
第五届染色体SMC复合物国际会议研讨会报告集锦
Hironori Niki,Yasuto Murayama
Hironori Niki
The fifth international meeting, entitled "SMC Complexes: Orchestrating Diverse Genome Functions", took place in Numazu City, Shizuoka, Japan from October 15-18, 2024. With 159 attendees (115 of whom were from 18 countries and regions), the...
Mihoko Kajita,Yojiro Matsui,Kotaro Sugimoto et al.
Mihoko Kajita et al.
Signal regulatory protein (SIRP) α, an inhibitory receptor belonging to the immunoglobulin (Ig) superfamily is abundantly expressed in phagocytes such as macrophages. CD47, the ligand for SIRPα, is expressed in most healthy cells, and cal...
TOB Proteins Repress Translation via the CCR4-NOT Deadenylase Complex Independent of Deadenylation [0.03%]
TOB蛋白通过CCR4-NOT去腺苷酸酶复合物独立于去腺苷酸化抑制翻译
Kanae Miyazaki,Takumi Tomohiro,Yoshinori Funakami et al.
Kanae Miyazaki et al.
Transducer of ErbB2 (TOB) proteins have been shown to promote mRNA decay through interactions with the CCR4-NOT complex and poly(A)-binding protein (PABP). While their role in deadenylation-mediated mRNA degradation is well established, the...
Meeting Report on the 1st Asia & Pacific Bioinformatics Joint Conference (APBJC 2024) [0.03%]
2024年亚太生物信息学联合会议(APBJC 2024)会议报告
Kiyoko F Aoki-Kinoshita,Susumu Goto
Kiyoko F Aoki-Kinoshita
The 1st Asia & Pacific Bioinformatics Conference (APBJC) covers a wide range of scientific topics in the oral sessions (black) and workshops (red) as well as the poster session. The numbers in parentheses indicate the number of presentation...
Kazuki Akiyama,Shuhei Tsuchihashi,Yusuke V Morimoto
Kazuki Akiyama
Retinal plays a key role in light absorption across prokaryotes and eukaryotes, both in rhodopsin and bacteriorhodopsin systems. The multicellular social amoeba Dictyostelium discoideum exhibits positive phototaxis. However, retinal binding...