An Upstream RUNX3 Enhancer, eR3 (-18m/-28h), Regulates the Development of Gut-Associated Anti-Tumorigenic CD8+CD103+ Cytotoxic T Lymphocytes in Mouse and Human [0.03%]
一个上游RUNX3增强子eR3（-18m/-28h）调节小鼠和人类相关抗肿瘤性CD8+CD103+细胞毒性T淋巴细胞的发育
Giselle Sek Suan Nah,Junichi Matsuo,Avinash Govind Bahirvani et al.
Giselle Sek Suan Nah et al.
The RUNX3 gene is frequently involved in a variety of cancers and immunological diseases. Despite such widespread association with human diseases, the transcriptional regulation of RUNX3 remains elusive. Here we report the identification of...
Quantitative Imaging Analysis of Internal Structural Complexity in Mouse Heart Organoids; Comparison to Mouse Embryonic Hearts [0.03%]
小鼠心脏器官体内的结构复杂性定量成像分析；与小鼠胚胎心脏的比较
Rin Kaneko,Fumitoshi Ishino,Jiyoung Lee
Rin Kaneko
We have established mouse heart organoids (mHOs) that are characterized by the presence of atrium- and ventricle-like structures that mimic entire embryonic hearts. However, maturation was not uniform, and little is known about their trabec...
The TAP/NXF1-Binding Region of HuD Is Required for Translation and Neuronal Differentiation [0.03%]
TAP/NXF1结合区对于HuD调控翻译和神经元分化是必需的
So Toshima,Ryosuke Satoh,Takumi Tomohiro et al.
So Toshima et al.
The neuronal ELAV protein HuD is known to promote neuronal differentiation and stimulate cap-dependent translation, but the underlying mechanism remains incompletely understood. Here, we identify a functional domain within the HuD linker th...
Decreased Mitochondrial Translation Suppresses 3,3'-Diindolylmethane-Induced Reactive Oxygen Species Generation in Schizosaccharomyces Pombe [0.03%]
线粒体翻译减少可抑制3,3'-二吲哚甲烷诱导的裂殖酵母活性氧生成
Kaiyu Wang,Hidenori Osawa,Hideto Nagai et al.
Kaiyu Wang et al.
Broccoli-derived 3,3'-diindolylmethane (DIM) exhibits anticancer effects. The compound also inhibits the growth of fission yeast cells. Reduction of mitochondrial translation alleviates the growth defects caused by DIM in fission yeast; how...
m6A RNA Modification Controls HTLV-1 Tax and Host Gene Expression [0.03%]
M6A RNA修饰调控HTLV-1 TAX及宿主基因表达
Rei Gibu,Kodai Gibu,Kako Suzuki et al.
Rei Gibu et al.
Human T-cell Leukemia Virus Type 1 (HTLV-1) is a pathogenic human retrovirus that is responsible for intractable diseases such as adult T-cell leukemia-lymphoma (ATL), a malignancy with a poor patient prognosis. Although recent studies have...
Knockdown of Cav2.2 Calcium Channel in Macrophages Aggravates Colitis Induced by Dextran Sodium Sulfate [0.03%]
在巨噬细胞中敲低Cav2.2钙通道可加重葡聚糖硫酸钠诱导的结肠炎
Hironao Saegusa,Xiaoxu Li,Xinshuang Wang et al.
Hironao Saegusa et al.
Voltage-dependent calcium channels (VDCCs) have previously been thought to be functional in excitable cells, but recently accumulating evidence suggests that they are also functional in non-excitable cells such as microglia. In the present ...
Machine Learning Extracts Radiation Resistant-Specific EdU Fluorescence Pattern in Cancer Cells [0.03%]
机器学习提取癌细胞中放射抵抗特异的EdU荧光模式
Masae Ikura,Tsuyoshi Ikura,Kanji Furuya
Masae Ikura
The thymidine analog EdU (5-ethynyl-2-deoxyuridine) is incorporated into DNA during replication and has traditionally been used as a marker of S-phase cells. In this study, we discovered that EdU fluorescence images display substantial cell...
Transcriptional Regulation of the Interferon Alpha-Inducible Protein-27 Like 2b by the Peroxisome Proliferator-Activated Receptor γ in Fatty Liver Disease [0.03%]
过氧化物酶体增殖激活受体γ在脂肪性肝病中调控干扰素诱导蛋白27样2b的转录
Ai Sakaguchi,Daisuke Aibara,Kimihiko Matsusue
Ai Sakaguchi
Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor abundantly expressed in the fatty liver of type 2 diabetic ob/ob mice. Herein, we investigated how PPARγ regulates the expression of the interferon alpha-inducibl...