Talk Until You Drop: Lively Discussions at the 7th International Conference on Plant Vascular Biology 2025 in Osaka [0.03%]
大阪召开第七届国际植物维管束生物学会议 热烈讨论直到深夜
Koh Aoki,Masashi Asahina,Tomomichi Fujita et al.
Koh Aoki et al.
The 7th International Conference on Plant Vascular Biology 2025 (PVB2025) took place at the KKR Hotel Osaka from July 7th to July 12th. The conference attracted 169 participants from 20 countries, including 105 attendees from outside Japan....
miR-205-5p Promotes Hepatic Fat Accumulation as a Downstream Effector of PPARγ Signaling [0.03%]
miR-205-5p作为PPARγ信号的下游效应物促进肝脂肪蓄积
Kohei Matsuo,Daisuke Aibara,Kimihiko Matsusue
Kohei Matsuo
Hepatic peroxisome proliferator-activated receptor gamma (PPARγ) promotes fat accumulation in the liver of leptin-deficient (ob/ob) mice. However, the mechanism underlying PPARγ-dependent fat accumulation remains unclear. In this study, w...
TCR Repertoire Analysis Quantifies Effect of Irradiation on Homeostasis of iNKT Cell Development in the Thymus of Mice [0.03%]
小鼠胸腺中的电离辐射对iNKT细胞发育的影响及稳态的定量分析研究
Kazumasa B Kaneko,Mio Hayama,Nanako Uchida et al.
Kazumasa B Kaneko et al.
Thymic T cell development shows homeostasis against various stressors. Invariant natural killer T (iNKT) cells in the thymus contribute to recovery of thymic development after irradiation owing to their initial tolerance to irradiation comp...
Processing of DNA Topoisomerase II-DNA-Protein Crosslinks Associated With Anticancer Drugs [0.03%]
抗癌药物诱导的DNA拓扑异构酶II-DNA-蛋白质交联的作用机制及处理方法研究进展
Ryo Sakasai,Kuniyoshi Iwabuchi
Ryo Sakasai
During cell division and gene expression, the DNA double-helical structure unwinds, thereby generating torsional stress. DNA topoisomerases are enzymes that relieve this stress. During this process, topoisomerases form temporary covalent bo...
DiCleavePlus: A Transformer-Based Model to Detect Human Dicer Cleavage Sites Within Cleavage Patterns [0.03%]
DiCleavePlus：一种基于Transformer的模型，用于在切割模式内检测人类Dicer切割位点
Lixuan Mu,Tatsuya Akutsu
Lixuan Mu
MicroRNAs (miRNAs) play a crucial role in posttranscriptional gene regulation. The biogenesis of mature miRNAs requires precise cleavage of precursor miRNAs (pre-miRNAs) by Dicer. Several computational approaches have been developed to pred...
Chromatin Landscape of Saccharomyces cerevisiae Acquiring H3K9 Methylation and Its Reader Molecule HP1 [0.03%]
带有H3K9甲基化染色质及其阅读蛋白HP1的酿酒酵母基因组重排景观研究
Taiki Shimizu,Kei Fukuda,Chikako Shimura et al.
Taiki Shimizu et al.
Histone H3 lysine 9 (H3K9) methylation and heterochromatin protein 1 (HP1) are well-conserved heterochromatin epigenomes and their reader molecules. However, the details of the importance of them in heterochromatin formation still remain un...
The Meeting Report on the VIIth International Workshop on SOX Transcription Factors [0.03%]
第七届SOX转录因子国际研讨会会议纪要
Masami Kanai-Azuma,Hiroshi Asahara,Kenta Yashiro et al.
Masami Kanai-Azuma et al.
The VIIth International Workshop on SOX Transcription Factors (SOX2025) was held at the Karuizawa Prince Hotel West, Nagano, Japan, from September 8 to 11, 2025. The meeting marked the 20th anniversary of the SOX conference series and broug...
Generation of a Triple Tag Knock-In Mouse to Visualize Precise Protein Localization Patterns for Type II Classic Cadherins During Brain Development [0.03%]
生成三重标签敲入小鼠以在脑发育过程中精确可视化II型经典钙黏蛋白的蛋白质定位模式
Mayuko Hotta,Yukiko U Inoue,Junko Asami et al.
Mayuko Hotta et al.
Classic cadherin cell-cell adhesion molecules with self-organizing activities play roles in segregating distinct populations of cells at developing brain regions and/or boundaries. However, the protein dynamics of each cadherin subclass in ...
GSK3β Regulates a Novel β-Catenin Degradation Pathway via the GID Complex in Wnt Signaling [0.03%]
Wnt信号传导中通过GID复合物调控的新颖的β-catenin降解途径中的GSK3β调节作用
Masahiro Shimizu,Hiroshi Shibuya
Masahiro Shimizu
The canonical Wnt signaling pathway plays a pivotal role in regulating cell proliferation, differentiation, and tissue homeostasis. These functions are largely regulated through the degradation of β-Catenin. Under Wnt-off conditions, β-Ca...
Cholic Acid-Induced Akkermansia Expansion and FGF-15 Upregulation Improve Diabetes While Exacerbating Steatohepatitis in TSOD Mice [0.03%]
丁酸盐诱导Akkermansia菌扩张和FGF-15上调可改善TSOD小鼠的糖尿病症状但加重肝炎病情
Miyuna Kato,Kana Goto,Koudai Kani et al.
Miyuna Kato et al.
Type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated steatohepatitis (MASH) frequently coexist and are mechanistically linked via insulin resistance, lipotoxicity, and chronic inflammation. Cholic acid (CA), a primary bile a...