AlphaFold2 Insights into c-Abl Transactivation by Adaptor c-Crk or Abi-1: Structural Forms, Active Site Types, and Multiple SH3-PxxPxK/R Interactions [0.03%]
AlphaFold2揭示Adaptor c-Crk或Abi-1激活c-Abl的机制：结构形式、活性位点类型及多个SH3-PxxPxK/R相互作用
Tomoyuki Shishido,Masahiro Fujihashi
Tomoyuki Shishido
This study used AlphaFold2 to investigate allosteric structural changes during c-Abl transactivation. Two structural forms of c-Abl (positions of SH2 and SH3 domains relative to kinase domain) and four active site types (types 0-3) were ide...
Turnover of NESTIN-Negative Neural Progenitors Into NESTIN-Positive State by the Lack of JMJD3 [0.03%]
JMJD3缺失使NESTIN阴性神经祖细胞向NESTIN阳性状态转变
Jiazi Chen,Tokuko Iwamori,Sakurako Shima et al.
Jiazi Chen et al.
Epigenetic regulation has fundamental roles in the maintenance and differentiation of neural stem cells as well as fate determination of neural lineage. Although neural differentiation is irreversible under physiological conditions, neural ...
Carboxyl-Terminal Region of the Maturation Protein of RNA Coliphage Qβ Mediates Host Attachment, Virion Formation, and Cell Lysis [0.03%]
大肠RNA噬菌体Qβ成熟蛋白羧基端调控区域介导宿主结合、噬菌体装配和细胞裂解作用
Masayuki Kajitani,Noriko Hakoshima,Yoshio Inokuchi
Masayuki Kajitani
The single-stranded RNA coliphage Qβ infects Escherichia coli by attaching to the host F-pilus and entering the host cells. The maturation protein (A2) within the virion is thought to mediate these events in the host cell. In this study, w...
Species-Specific Parent-Of-Origin Expression of Adam23 in the Mammalian Brain [0.03%]
哺乳动物大脑中Adam23基因的物种特异性印记表达
Makiko Meguro-Horike,Kengo Saito,Miyuki Shimazu et al.
Makiko Meguro-Horike et al.
Genomic imprinting is a parent-of-origin-dependent epigenetic mechanism with established roles in placental development and fetal growth in mice, whereas its contribution to brain function and evolution remains incompletely understood. Here...
Coexpression of MYCN and ALK Induces Neuroblastoma-Like Tumors From Human iPS Cell-Derived Cranial Neural Crest Cells [0.03%]
MYCN和ALK共表达诱导人IPS细胞衍生的颅神经嵴细胞发生神经母细胞瘤样的肿瘤
Tianyuan Shi,Kyosuke Mukae,Maya Shindo et al.
Tianyuan Shi et al.
Neuroblastoma (NB) is a pediatric solid tumor originating from neural crest cells (NCCs), which are precursors of the sympathetic nervous system. MYCN amplification is a key factor contributing to the poor prognosis of NB. Anaplastic lympho...
Desmosome Assembly Regulates Apical-Basal Polarization and Nuclear Shape in Simple Epithelial Cells [0.03%]
粘附连接的装配调控简单上皮细胞的极性和核形态
Tobuhiro Nita,Junya Hayase,Akira Kohda et al.
Tobuhiro Nita et al.
In epithelia, the desmosome is a cell-cell adhesive junction that anchors keratin filaments, thereby providing tissue integrity and mechanical resistance. Compared with considerable study on the desmosome in stratified epithelia, the mechan...
Roles of a Drosophila ADAM 10 Transmembrane Metalloprotease, Kuzbanian, in Tissue Architecture and Function of the Adult Adipose Tissue [0.03%]
果蝇跨膜金属蛋白酶Kuzbanian (Adam10)在成脂组织结构和功能中的作用
Yusaku Hayashi,Taiichi Tsuyama,Tadao Usui et al.
Yusaku Hayashi et al.
Various molecular mechanisms in mature adipose tissue regulate whole-body physiology. In contrast, our current understanding of the development of this tissue is limited. The adult fat body (AFB) of Drosophila melanogaster is an emerging mo...
Deficiency of δ-Aminolevulinate Dehydratase Confers a Survival Advantage and Drives Malignancy in Cancer [0.03%]
琥珀酰丙亚胺焦磷酸酶缺乏通过促进肿瘤发生驱动癌症恶化
Seiya Watanabe,Taku Chibazakura
Seiya Watanabe
Heme synthesis has been considered essential, yet cancer cells paradoxically maintain high proliferation despite suppressing the pathway, with low expression of δ-aminolevulinate dehydratase (ALAD), the second enzyme of the pathway, which ...
Development of Truncated Malarial Var2CSA-Displaying Baculovirus Vectors and Their Gene Delivery Efficiency in HepG2 Cells [0.03%]
截短型疟原虫Var2CSA蛋白表达杆状病毒载体的构建及其在HepG2细胞中的转导效率研究
Chiaki Kawabata,Benoit Gamain,Takahiko Tamura
Chiaki Kawabata
Var2CSA, a member of the Plasmodium falciparum erythrocyte membrane protein (PfEMP) family, specifically binds to various human cancer cells through oncofetal chondroitin sulfate (ofCS) expressed on cell surfaces. This unique binding proper...
Lobe-Less, a Long Noncoding RNA That Regulates Drosophila Mushroom Body Morphogenesis [0.03%]
调控果蝇蘑菇体形态发生的长链非编码RNA Lobe-Less
Sachi Inagaki,Natsuki Nakamura,Mitsutaka Kadota et al.
Sachi Inagaki et al.
Long noncoding RNAs (lncRNAs) are abundantly transcribed in eukaryotes, but most of their physiological roles, especially in neural development, remain unclear due to limited in vivo studies. Here we show that Lobe-less (LOL) lncRNA of Dros...