Regulation of the Growth-Inhibitory Activity of Fhl1 via Interaction With Ifh1 and Crf1 at the Ribosomal Protein Gene Promoters in Saccharomyces cerevisiae [0.03%]
通过芽殖酵母核糖体蛋白基因启动子上Ifh1和Crf1的相互作用调控Fhl1的生长抑制活性
Naoki Shimamura,Koji Kasahara
Naoki Shimamura
The transcription factor Fhl1, which binds to the promoters of the ribosomal protein genes (RPGs) in Saccharomyces cerevisiae, promotes transcription by recruiting the transcription activator Ifh1 under nutrient-rich conditions. During star...
Functional Role of COP1 Gene in Hepatocellular Carcinoma Lipid Metabolism and Stemness [0.03%]
COP1基因在肝癌细胞脂代谢及干性维持中的功能作用研究
Eun-Hye Jeon,An-Na Bae,Hajin Lee et al.
Eun-Hye Jeon et al.
We have previously defined the constitutive photomorphogenic protein 1 (COP1) gene as a therapeutic target in hepatocellular carcinoma (HCC). A recent study demonstrated that COP1 induces non-alcoholic fatty liver disease (NAFLD), a precurs...
Molecular Mechanism of Caspase-8-Dependent Interleukin-18 Activation in Pancreatic Cancer Cells Induced by 5-Fluorouracil and Nutrient Starvation [0.03%]
5-氟尿嘧啶和营养缺乏通过Caspas-8依赖性方式活化胰腺癌细胞中IL-18的分子机制研究
Hiroki Kamino,Yuko Nariai,Takeshi Urano
Hiroki Kamino
Interleukin-18 (IL-18) is a pro-inflammatory cytokine, and higher IL-18 expression in pancreatic tumors is associated with poor prognosis. Although 5-fluorouracil (5-FU) has been reported to induce the release of bioactive (mature/cleaved) ...
The I-BAR Protein baiap2l1a Is Required for Protrusion and Lateral Elongation of Microridges [0.03%]
I-_BAR蛋白BAIP2L1A是微脊突起和侧向延伸所必需的蛋白质
Yasuko Inaba,Kimika Iwasaki,Aoi Nakamura et al.
Yasuko Inaba et al.
Microridges are laterally elongated membrane protrusions of epithelial cells. Microridges are arranged in maze-like patterns and found on various mucosal epithelia, including the skin of zebrafish, where they are required to maintain mucus....
Efficient Induction of Oligodendrocyte Lineage From Pluripotent Stem Cells via Temporal Modulation of OLIG2(S147A) and SOX10 [0.03%]
高效且精确地诱导多能干细胞向少突胶质前体细胞的分化
Mitsuru Ishikawa,Yoshiki Izumizawa,Sopak Supakul et al.
Mitsuru Ishikawa et al.
Several protocols for generating oligodendrocytes (OLs) from human pluripotent stem cells have been reported. However, they are limited by long culture duration, intensive handling, and low yield of mature OLs. Transcription factor-based st...
International Symposium on Protein and Organelle Lifetime Regulation (ISPO2025): From Turnover Mechanisms to Targeted Control [0.03%]
国际蛋白质与细胞器寿命调控大会(ISPO2025)：从周转机制到靶向控制
Shigeo Murata,Jun Hamazaki,Yuri Shibata
Shigeo Murata
The International Symposium on Protein and Organelle Lifetime Regulation (ISPO2025) was held on 30 October-2 November 2025 at Nara Kasugano Forum Iraka, Nara, Japan. The meeting was organized by the core members of the Transformative Resear...
Distinct Behavioral Roles of D-Aspartate Oxidases DDO-1 and DDO-2 in Caenorhabditis elegans [0.03%]
秀丽隐杆线虫D-天冬氨酸氧化酶DDO-1和DDO-2在不同行为中的独特作用
Yasuaki Saitoh,Masumi Katane,Tetsuya Miyamoto et al.
Yasuaki Saitoh et al.
D-amino acids are widely distributed across organisms, and their metabolism contributes to the regulation of neuronal activity and behavior. Whereas most animals possess one D-amino acid oxidase (DAAO) for neutral and basic D-amino acids an...
Introns as Protective Buffers Against Transposable Elements Invasion During Genome Gigantism in a Newt [0.03%]
蝾螈基因组巨化过程中内含子作为保护缓冲区防御转座元件入侵作用
Kazuto Bou,Kiyokazu Agata
Kazuto Bou
Genome gigantism has long been linked to recurrent bursts of transposable element (TE) activity, yet how such bursts reshape gene architecture over evolutionary time remains poorly understood. By comparing two independently assembled genome...
5-Aza-Cytidine Enhances Terminal Polyadenylation Site Usage for Full-Length Transcripts in Cells [0.03%]
5-aza-cytidine促进细胞全长转录本使用末端多腺苷酸化位点
Samuel Ogunsola,Ling Liu,Urmi Das et al.
Samuel Ogunsola et al.
As an inhibitor of DNA methyltransferases (DNMTs) and an anti-cancer drug, 5-aza-cytidine (5-azaC)'s many effects on gene expression remain unclear. Here, we show that 5-azaC treatment of cultured GH3 pituitary tumor cells increases relativ...
Developing a Robust Multiround HCR-FISH Method Modified for Caenorhabditis elegans [0.03%]
改良版线虫多轮HCR-FISH实验方法的发展完善
Xiaoxiong Yang,Jingxuan Zeng,Chung-Kuan Chen et al.
Xiaoxiong Yang et al.
Visualizing multiplexed gene expression patterns at cellular resolution is fundamental for understanding complex biological systems. Iterative protocols, such as sequential fluorescent in situ hybridization (FISH) have been widely used for ...