FOXO1 Is Required for Growth and Viability of Cancer-Associated Fibroblasts in Human Breast Carcinomas [0.03%]
FOXO1是人类乳腺癌细胞外基质纤维母细胞生长和存活的必需因素
Takumi Koyama,Tetsuo Kobayashi,Yoshihiro Mezawa et al.
Takumi Koyama et al.
Carcinoma-associated fibroblasts (CAFs), frequently present in the stroma of human breast carcinomas, influence tumor characteristics. A forkhead box protein O1 (FOXO1) transcription factor is a critical mediator of the cellular responses t...
Strain-Dependent Functional Variation of a Sex Specific Sox9 Enhancer [0.03%]
应变依赖性的性别特异性Sox9增强子的功能变异
Iku Tsuchiya,Atsumi Tsuji-Hosokawa,Suzune Furuhashi et al.
Iku Tsuchiya et al.
In mammalian sex differentiation, Sox9 expression in undifferentiated gonads determines male development. Sox9 is regulated by multiple enhancers, of which Enh13/mXYSRa is the most critical. Disruption of the GATA4 binding site in Enh13/mXY...
An Outflow Tract Myocardium-Specific Enhancer at the Sema3c Locus During Heart Development [0.03%]
心脏发育过程中Sema3c位点的一个流出道心肌特异性增强子
Yunce Wang,Yukihiro Harada,Tomoe Ueyama et al.
Yunce Wang et al.
Sema3c is specifically expressed in the cardiac outflow tract (OFT) of the developing mouse heart and has been implicated in OFT polarization and great artery formation. However, the regulatory basis underlying its spatially restricted expr...
A Persistent Homology Approach Enables Single-Cell Detection of Chromatin Spatial Organization Changes During Pathological Senescence Transition [0.03%]
persistence同源性方法能够实现单细胞检测染色质空间组织在病理衰老过程中的变化
Kanji Furuya,Yoshitaka Umeno,Masae Ikura et al.
Kanji Furuya et al.
Chromatin organization changes during aging, accompanied by alterations in higher-order chromosome architecture, contributing to the acquisition of senescent cell-specific functions. Recent studies have revealed that chromatin states and th...
Stepwise Evaluation of Plasmid- and Adeno-Associated Virus-Based Knock-In Using A Triple-Reporter Platform [0.03%]
利用三合一报告基因平台逐步评估基于质粒和腺相关病毒的敲入效应
Hiromasa Hara,Hideki Uosaki,Fumio Nakahara et al.
Hiromasa Hara et al.
Homology-directed repair (HDR)-mediated knock-in efficiency is a composite of double-strand break (DSB) induction and repair pathway selection during targeted insertion. Thus, optimization of HDR-mediated knock-in presents significant chall...
Interaction Between Rec8 and Mis4 Is Required for Axis-Loop Chromatin Formation and Homologous Chromosome Recombination During Meiosis [0.03%]
Rec8与Mis4的相互作用要求形成轴丝环染色质及减数分裂同源染色体重组事件发生
Takeshi Sakuno,Yasuto Murayama,Tokuko Haraguchi et al.
Takeshi Sakuno et al.
The Rec8 cohesin complex is required for the pairing and recombination of homologous chromosomes during meiosis, as well as for the cohesion of sister chromatids. In the fission yeast Schizosaccharomyces pombe, we previously identified a re...
Microarray-Based Identification of Time-Sensitive miRNAs as Serum Quality Indicators in Liquid Biopsy [0.03%]
基于微阵列的时效性miRNA识别作为液态活检中血清质量指标
Satoko Takizawa,Atsuko Mizoguchi,Hiroko Sudo et al.
Satoko Takizawa et al.
Circulating microRNAs (miRNAs) are promising biomarkers and many studies have been reported. However, there are discrepancies between studies due to differences in the inclusion criteria, experimental procedures, and serum/plasma processing...
Murine Embryonic Stem Cells Possess Distinct E2F Activity That Activates Tumor Suppressor Promoter Elements [0.03%]
小鼠胚胎干细胞具有独特的E2F活性，可激活肿瘤抑制子启动子元件
Yaxuan Zhou,Rinka Nakajima,Mashiro Shirasawa et al.
Yaxuan Zhou et al.
The transcription factor E2F plays crucial roles in cell proliferation and tumor suppression. In the resting state of normal cells, E2F activity is suppressed by binding of the tumor suppressor pRB and its family members. E2F activated by g...
Novel Ligands for the Orphan Receptor GPR151 Modulate Morphine Action [0.03%]
新型孤儿受体GPR151配体通过调节吗啡作用来发挥功效
Hijiri Yoshida,Takashi Suto,Hiroyuki Hirano et al.
Hijiri Yoshida et al.
GPR151 is an orphan G-protein-coupled receptor expressed on specific neurons. Its expression has been reported to be upregulated in the dorsal root ganglia in mouse nerve injury models, suggesting a role in pain transmission. We used our un...