Suppression of LUBAC-mediated linear ubiquitination by a specific interaction between LUBAC and the deubiquitinases CYLD and OTULIN [0.03%]
LUBAC介导的线性泛素化被LUBAC与去泛素酶CYLD和OTULIN特异相互作用所抑制
Tsuyoshi Takiuchi,Tomoko Nakagawa,Hironari Tamiya et al.
Tsuyoshi Takiuchi et al.
Linear ubiquitin chains generated by the linear ubiquitin chain assembly complex (LUBAC) play an important role in NF-κB activation. However, the regulation of linear ubiquitin chain generation by LUBAC is not well characterized. Here, we ...
Derivation of human differential photoreceptor cells from adult human dermal fibroblasts by defined combinations of CRX, RAX, OTX2 and NEUROD [0.03%]
CRX，RAX，OTX2和NEUROD确定组合诱导人成纤维细胞分化为视网膜感光细胞
Yuko Seko,Noriyuki Azuma,Toshiyuki Ishii et al.
Yuko Seko et al.
Redirecting differentiation of somatic cells by over-expression of transcription factors is a promising approach for regenerative medicine, elucidation of pathogenesis and development of new therapies. We have previously defined a transcrip...
Dysregulation of the proteasome increases the toxicity of ALS-linked mutant SOD1 [0.03%]
蛋白酶体失调可增加ALS突变SOD1毒性
Akira Kitamura,Noriko Inada,Hiroshi Kubota et al.
Akira Kitamura et al.
A hallmark of protein conformational disease, exemplified by neurodegenerative disorders, is the expression of misfolded and aggregated proteins. The relationship between protein aggregation and cellular toxicity is complex, and various mod...
Functional link between Rab GTPase-mediated membrane trafficking and PI4,5P2 signaling [0.03%]
Rab小G蛋白介导的膜转运与磷脂PI4,5P2信号的功能联系
Cuifang Li,Ayako Kita,Yuuka Hashimoto et al.
Cuifang Li et al.
Fission yeast its3(+) encodes an essential phosphatidylinositol-4-phosphate 5-kinase (PI4P5K) that regulates cell integrity and cytokinesis. We performed a genetic screen to identify genes that function in PI4P5K-mediated signaling, and ide...
Interaction between RB protein and NuMA is required for proper alignment of spindle microtubules [0.03%]
RB蛋白和NuMA的相互作用对纺锤体微管的正常排列是必需的
Chiharu Uchida,Takayuki Hattori,Hirotaka Takahashi et al.
Chiharu Uchida et al.
Retinoblastoma protein (pRB) controls cell cycle progression and cell cycle exit through interactions with cellular proteins. Many pRB-binding proteins, which function in gene transcription or modulation of chromatin structure, harbor LXCXE...
Kentaro Nobutani,Yohei Shimono,Midori Yoshida et al.
Kentaro Nobutani et al.
Previous studies using cultured cells showed that primary cilia are present in quiescent cells, but are absent in proliferating cells. We studied here the relationship between the presence or absence of primary cilia and the cell cycle arre...
Population of ATP synthase molecules in mitochondria is limited by available 6.8-kDa proteolipid protein (MLQ) [0.03%]
线粒体ATP合成酶分子数量受6.8-kDa孔蛋白(MLQ)含量限制
Makoto Fujikawa,Shigenori Ohsakaya,Kanako Sugawara et al.
Makoto Fujikawa et al.
A 6.8-kDa proteolipid (called MLQ) is a hydrophobic mitochondrial protein with unknown function that is loosely associated with ATP synthase. Here, we show that MLQ-knockdown HeLa cells lose population of ATP synthase in mitochondria. This ...
Fission yeast IQGAP maintains F-actin-independent localization of myosin-II in the contractile ring [0.03%]
裂殖酵母IQGAP维持环形肌动蛋白独立的肌球蛋白II细胞质皮层定位
Masak Takaine,Osamu Numata,Kentaro Nakano
Masak Takaine
During cytokinesis in many eukaryotic cells, myosin-II concentrates at the equatorial cortex with actin filaments (F-actin) and is supposed to generate forces to divide the cell into two, which is called the contractile ring (CR) hypothesis...
Kenkichi Sugimoto,Suzuka Yoshida,Yuka Mashio et al.
Kenkichi Sugimoto et al.
Murine MS-K and NFSA cell lines formed tumor after inoculation into mouse and both cell lines expressed high level of vascular endothelial growth factor-A (vegf-A) and produced same level of VEGF-A. However, poor blood vessel formation, and...
Insertion of long interspersed element-1 in the Mitf gene is associated with altered neurobehavior of the black-eyed white Mitf(mi-bw) mouse [0.03%]
Mitf基因中的长散在元件-1插入与黑眼白化小鼠异常神经行为相关
Kazuhisa Takeda,Hiroki Hozumi,Kunihiko Nakai et al.
Kazuhisa Takeda et al.
Microphthalmia-associated transcription factor (Mitf) is required for the differentiation of melanoblasts of the neural crest origin. The mouse homozygous for the black-eyed white (Mitf(mi-bw) ) allele is characterized by white-coat color a...