Masahiro Nakagawa,Megumi Kagiyama,Nobuyuki Shibata et al.
Masahiro Nakagawa et al.
Arabidopsis receptors of abscisic acid (ABA), the key plant hormone for adaptation to water stress, comprise 14 PYR/PYLs/RCARs proteins classified into three subfamilies I, II, and III, which suggests functional differentiation. Although th...
Roles of cell division control factor SdiA: recognition of quorum sensing signals and modulation of transcription regulation targets [0.03%]
细胞分裂调控因子SdiA的作用：群体感应信号识别及转录调节目标的调控
Tomohiro Shimada,Kaori Shimada,Makoto Matsui et al.
Tomohiro Shimada et al.
In Gram-negative bacteria, N-acylhomoserine lactone (HSL) is used as a signal in cell-cell communication and quorum sensing (QS). The model prokaryote Escherichia coli lacks the system of HSL synthesis, but is capable of monitoring HSL sign...
Herbal drug ninjin'yoeito accelerates myelopoiesis but not erythropoiesis in vitro [0.03%]
中药九味羌活汤体外加速髓系分化但不能促进红系分化
Tomoko Inoue,Kasem Kulkeaw,Kanitta Muennu et al.
Tomoko Inoue et al.
Some Kampo medicines that are herbal and traditional in Japan have had beneficial effects when given to patients with anemia. However, molecular mechanisms underlying their effects are unclear. To address this question, four Kampo medicines...
FAST-id system for enrichment of cells with TALEN-induced mutations and large deletions [0.03%]
基于TALEN诱导突变和大片段缺失的快速富集系统
Daisuke Tokumasu,Tetsushi Sakuma,Yoko Hayashi et al.
Daisuke Tokumasu et al.
Transcription activator-like effector nuclease (TALEN)-mediated genome editing is a powerful technique for analyzing gene functions in various cells and organisms. At target loci, TALENs can not only introduce short insertions and deletions...
Masaru Ito,Kazuto Kugou,Jeffrey A Fawcett et al.
Masaru Ito et al.
Meiotic chromosome architecture called 'axis-loop structures' and histone modifications have been shown to regulate the Spo11-dependent formation of DNA double-strand breaks (DSBs) that trigger meiotic recombination. Using genome-wide chrom...
Establishment and directed differentiation of induced pluripotent stem cells from glycogen storage disease type Ib patient [0.03%]
I型糖原贮积症患者诱导多能干细胞的建立和定向分化
Daisuke Satoh,Tohru Maeda,Tetsuya Ito et al.
Daisuke Satoh et al.
Glycogen storage disease type Ib (GSDIb) is caused by a deficiency in the glucose-6-phosphate transporter (G6PT), which leads to neutrophil dysfunction. However, the underlying causes of these dysfunctions and their relationship with glucos...
Aberrant DNA methylation status of DNA repair genes in breast cancer treated with neoadjuvant chemotherapy [0.03%]
新辅助化疗乳腺癌中DNA修复基因异常甲基化状态分析
Yoshiyuki Watanabe,Ichiro Maeda,Ritsuko Oikawa et al.
Yoshiyuki Watanabe et al.
Dysregulation of homologous recombination (HR) DNA repair has been implicated in breast carcinogenesis and chemosensitivity. Here, we investigated the methylation status of sixteen HR genes and analyzed their association with tumor subtypes...
Keap1-Nrf2 system regulates cell fate determination of hematopoietic stem cells [0.03%]
KEAP1-Nrf2系统调节造血干细胞的命运决定
Shohei Murakami,Ritsuko Shimizu,Paul-Henri Romeo et al.
Shohei Murakami et al.
Nrf2 is a major transcriptional activator of cytoprotective genes against oxidative/electrophilic stress, and Keap1 negatively regulates Nrf2. Emerging works have also suggested a role for Nrf2 as a regulator of differentiation in various c...