Reversing frailty: The transformative effects of structured physical-activity-based physiotherapy on physical, cognitive and emotional health in older adults-An evidence-based systematic review [0.03%]
逆转衰老：基于结构化身体活动的物理治疗对老年人身心健康的影响——一项循证系统综述
Moattar Raza Rizvi,Ankita Sharma,Faizan Z Kashoo et al.
Moattar Raza Rizvi et al.
Background: Elderly frailty is a multifaceted clinical condition with diminished physiological reserves and increased stress susceptibility. It increases disability, hospitalization and mortality rates, requiring multidom...
HDL function and composition in atherothrombotic cardiovascular disease with very high HDL-C [0.03%]
极高高密度脂蛋白胆固醇水平动脉粥样硬化性心血管病患者的功能及组分特点
Teresa Padro,Natàlia Muñoz-García,Marta Fanlo-Maresma et al.
Teresa Padro et al.
Background: Emerging evidence demonstrates a J-shaped relationship between HDL-C levels and atherosclerotic cardiovascular disease (ASCVD) with very high HDL-C concentrations paradoxically associated with increased ASCVD ...
Harnessing controlled human infection models to accelerate vaccine development for neglected tropical diseases: Lessons from leishmaniasis [0.03%]
利用控制的人类感染模型加速被忽视的热带病疫苗研发：利什曼病的经验教训
Vivak Parkash
Vivak Parkash
Background: Controlled Human Infection Models (CHIMs) offer a powerful approach to expedite vaccine development by enabling early evaluation of vaccine candidate efficacy and immune responses. Their role is increasingly r...
Mapping Alzheimer's disease heterogeneity with molecular imaging biomarkers [0.03%]
利用分子影像生物标志物绘制阿尔茨海默病的异质性图谱
Elif Harput,Cecilia Boccalini,Gregory Mathoux et al.
Elif Harput et al.
Background: Alzheimer's disease (AD) is neuropathologically defined by the buildup of misfolded proteins such as extracellular amyloid-β (Aβ) and intracellular tau neurofibrillary tangles. AD also extends beyond these p...
Real-world evidence and observational studies: Methodological challenges in clinical research [0.03%]
真实世界证据和观察性研究：临床研究中的方法学挑战
Carmine Zoccali,Giovanni Tripepi
Carmine Zoccali
The emergence of real-world evidence (RWE) has significantly broadened the scope of clinical research in internal medicine, providing insights that extend beyond the constraints of randomized controlled trials (RCTs). RWE is generated from ...
Adipose tissue metabolomics identifies disease stage and tumour invasiveness of rectal cancer [0.03%]
脂肪组织代谢组学确定直肠癌的疾病阶段和肿瘤侵袭性
Lidia Cornejo Fernández,Laura Gallardo-Nuell,Anna Pigem Rodeja et al.
Lidia Cornejo Fernández et al.
Backgorund: Adipose tissue has emerged as a prognostic factor in rectal cancer (RC), yet its metabolic role in tumour progression remains poorly understood. This study aims to characterise the metabolic profiles of subcut...
Fibroblast-driven MMP-9/TIMP-1 imbalance in bronchoalveolar lavage reflects fibrotic progression in interstitial lung disease [0.03%]
肺泡灌洗液中的成纤维细胞驱动的MMP-9 / TIMP-1失衡反映了间质性肺病中的纤维化进展
Maria Bertolotto,Daniela de Totero,Paolo Giannoni et al.
Maria Bertolotto et al.
Background: Interstitial lung diseases (ILDs) are characterized by progressive fibrosis, in which extracellular matrix remodelling is regulated by matrix metalloproteinases (MMPs) and their inhibitors (TIMPs). The MMP-9/T...
IL-6 in the spotlight: From cardiovascular pathophysiology to therapy [0.03%]
白细胞介素6(IL-6)：从心血管病理生理学到治疗学
Alberto Preda,Amedeo Tirandi,Giulio Leo et al.
Alberto Preda et al.
Background: Interleukin-6 (IL-6), a pro-inflammatory cytokine and anti-inflammatory myokine, is involved in immune regulation and metabolic control. Persistent IL-6 activation, particularly via trans-signalling, is implic...
Giuseppe De Girolamo,Moris Sangineto,Giuseppe Di Gioia et al.
Giuseppe De Girolamo et al.
Background: Intentional weight loss improves obesity-related outcomes but reduces lean body mass, raising concern about skeletal muscle mass, function and long-term health. GLP-1 receptor agonists (GLP-1RAs) produce clini...
Hemodynamic and microcirculatory early adaptations following transcatheter aortic valve implantation (TAVI): A physiological pilot study [0.03%]
经导管主动脉瓣植入术（TAVI）后血流动力学和微循环早期适应的生理学研究
Stanislas Abrard,Sarah Mauler,Ivo Neto Silva et al.
Stanislas Abrard et al.
Background: Transcatheter aortic valve implantation (TAVI) abruptly relieves aortic stenosis. The consequences for the peripheral vascular network, organ perfusion and postoperative organ dysfunction remain unclear. This ...