Patient-reported outcomes in internal medicine: Methodological considerations for valid measurement and interpretation [0.03%]
内科医疗中的患者报告结果指标：有效测量与解读的方法学考虑因素
Carmine Zoccali,Giovanni Tripepi
Carmine Zoccali
Patient-reported outcome measures (PROMs) have become essential in contemporary internal medicine, where chronic, multisystem diseases and comorbidities make traditional biomedical endpoints insufficient as sole indicators of therapeutic be...
Infectious seeds of valve calcification: Exploring the bacterial hypothesis in the pathogenesis of calcific aortic valve disease [0.03%]
瓣膜钙化的传染性种子：探讨细菌假说在钙化主动脉瓣病发病机制中的作用
Antonella Forlino,Paola Giordani,Cristina Merla et al.
Antonella Forlino et al.
Background: Calcific aortic valve disease (CAVD) is a multifactorial condition characterized by progressive leaflet calcification with a potential role for bacterial colonization in its pathogenesis. This study investigat...
Observational Study
European journal of clinical investigation. 2026 Mar;56(3):e70188. DOI:10.1111/eci.70188 2026
Rahul Aggarwal,Deepak L Bhatt
Rahul Aggarwal
Background: Clinical trials are an important part of evidence generation in medicine but remain burdened by escalating costs, inefficiencies and manual processes. Artificial intelligence (AI) has emerged as a promising ap...
Practical considerations for the use of vericiguat in older patients with heart failure and reduced ejection fraction [0.03%]
用于射血分数降低的心力衰竭老年患者的维立西呱的实用考量
Francesco Castelletti,Elena Bianco,Giulia Fabro et al.
Francesco Castelletti et al.
Background: Worsening heart failure (WHF) is a red flag in the natural history of heart failure (HF) that negatively impacts the prognosis. Urgent improvements in the management of WHF, especially among HF with reduced ej...
Exercise-induced immune response in breast cancer patients during prehabilitation, neoadjuvant or adjuvant treatment: A systematic review and meta-analysis [0.03%]
系统综述与meta分析：乳腺癌患者在术前准备、新辅助或辅助治疗期间运动诱导的免疫反应
Simone Ubaghs,Kenza Mostaqim,Astrid Lahousse et al.
Simone Ubaghs et al.
Background: Adjuvant and neoadjuvant treatment for breast cancer (BC) such as chemotherapy and radiotherapy can lead to immune system impairment. Exercise is hypothesized to mitigate these effects by modulating immune res...
Increased levels of serum surfactant protein D are associated with cardiovascular disease incidence in the Spanish adult population: Di@bet.es study [0.03%]
血浆肺表面活性物质蛋白D水平与西班牙成人糖尿病患者心血管病发病率相关性：Di@bet.es研究
Wasima Oualla-Bachiri,Ana Lago-Sampedro,Eva García-Escobar et al.
Wasima Oualla-Bachiri et al.
Aims: Cardiovascular disease (CVD) remains the leading cause of mortality. New biomarkers are needed to improve CVD risk prediction. Several studies have reported associations between surfactant protein D (SP-D), an innat...
Can ammonia scavenging treat MASLD? Evaluating the evidence for L-ornithine L-aspartate-A systematic review [0.03%]
鸟氨酸-天冬氨酸治疗MASLD的疗效如何？一项系统综述
Abdulrahman Ismaiel,Vera Ciornolutchii,Stefan-Lucian Popa et al.
Abdulrahman Ismaiel et al.
Introduction: While hyperammonemia is traditionally associated with decompensated cirrhosis, emerging evidence suggests that disturbances in nitrogen homeostasis contribute to disease progression in earlier stages of stea...
Beyond glycemic control: How incretins are changing the cardiovascular trajectories of diabetes and obesity [0.03%]
超越血糖控制：肠泌肽如何改变糖尿病和肥胖症的心血管预后
Angelo Avogaro
Angelo Avogaro
Background: Diabetes mellitus is a leading global health concern. The parallel rise in obesity has exacerbated this burden, with projections suggesting over half of the adult population will be overweight or obese by 2050...
Improving end-of-life care in the cardiac intensive care unit: Navigating the challenge of timing palliative care intervention [0.03%]
心脏重症监护室临终期的改善：缓和治疗介入时机的挑战及应对策略分析
Simona Giubilato,Roberta Della Bona,Alessia Gambaro et al.
Simona Giubilato et al.
Background: Integrating end-of-life (EoL) care in cardiac intensive care units (CICUs) is particularly complex because it requires a shift from a purely curative approach to one that emphasizes symptom management, emotion...