Real-world evidence and observational studies: Methodological challenges in clinical research [0.03%]
真实世界证据和观察性研究：临床研究中的方法学挑战
Carmine Zoccali,Giovanni Tripepi
Carmine Zoccali
The emergence of real-world evidence (RWE) has significantly broadened the scope of clinical research in internal medicine, providing insights that extend beyond the constraints of randomized controlled trials (RCTs). RWE is generated from ...
Adipose tissue metabolomics identifies disease stage and tumour invasiveness of rectal cancer [0.03%]
脂肪组织代谢组学确定直肠癌的疾病阶段和肿瘤侵袭性
Lidia Cornejo Fernández,Laura Gallardo-Nuell,Anna Pigem Rodeja et al.
Lidia Cornejo Fernández et al.
Backgorund: Adipose tissue has emerged as a prognostic factor in rectal cancer (RC), yet its metabolic role in tumour progression remains poorly understood. This study aims to characterise the metabolic profiles of subcut...
Fibroblast-driven MMP-9/TIMP-1 imbalance in bronchoalveolar lavage reflects fibrotic progression in interstitial lung disease [0.03%]
肺泡灌洗液中的成纤维细胞驱动的MMP-9 / TIMP-1失衡反映了间质性肺病中的纤维化进展
Maria Bertolotto,Daniela de Totero,Paolo Giannoni et al.
Maria Bertolotto et al.
Background: Interstitial lung diseases (ILDs) are characterized by progressive fibrosis, in which extracellular matrix remodelling is regulated by matrix metalloproteinases (MMPs) and their inhibitors (TIMPs). The MMP-9/T...
IL-6 in the spotlight: From cardiovascular pathophysiology to therapy [0.03%]
白细胞介素6(IL-6)：从心血管病理生理学到治疗学
Alberto Preda,Amedeo Tirandi,Giulio Leo et al.
Alberto Preda et al.
Background: Interleukin-6 (IL-6), a pro-inflammatory cytokine and anti-inflammatory myokine, is involved in immune regulation and metabolic control. Persistent IL-6 activation, particularly via trans-signalling, is implic...
Giuseppe De Girolamo,Moris Sangineto,Giuseppe Di Gioia et al.
Giuseppe De Girolamo et al.
Background: Intentional weight loss improves obesity-related outcomes but reduces lean body mass, raising concern about skeletal muscle mass, function and long-term health. GLP-1 receptor agonists (GLP-1RAs) produce clini...
Hemodynamic and microcirculatory early adaptations following transcatheter aortic valve implantation (TAVI): A physiological pilot study [0.03%]
经导管主动脉瓣植入术（TAVI）后血流动力学和微循环早期适应的生理学研究
Stanislas Abrard,Sarah Mauler,Ivo Neto Silva et al.
Stanislas Abrard et al.
Background: Transcatheter aortic valve implantation (TAVI) abruptly relieves aortic stenosis. The consequences for the peripheral vascular network, organ perfusion and postoperative organ dysfunction remain unclear. This ...
Comparison between thoracic ultrasound and chest x-ray in detection of non-infective early complications of cardiac implantable electronic devices implantation (CRUSADERS study) [0.03%]
心脏植入式电子设备植入术后非感染早期并发症的胸部超声和胸片对比研究(CRUSADERS研究)
Roberto Floris,Gabriele Dell&#x;Era,Lorenzo Pimpini et al.
Roberto Floris et al.
Background and aims: Chest radiography (CXR) is the gold standard tool for early mechanical complications' detection after cardiac implantable electronic devices (CIED) procedures, along with CIED electrical parameters co...
Hun Jee Choe,Talal Almas,Ian J Neeland et al.
Hun Jee Choe et al.
Background: Obesity and atherogenic dyslipidemias are interrelated disorders that substantially contribute to the development of atherosclerotic cardiovascular disease (ASCVD) and the broader cardiovascular-kidney-metabol...
Alberto M Borobia,Juliette Guillot,Amanda Bok et al.
Alberto M Borobia et al.
The conservativeness of standard C statistics in the prediction of clinical events [0.03%]
标准循环内皮活化标志物预测心血管事件的保守性分析
Carmine Zoccali,Giovanni Tripepi
Carmine Zoccali
The C statistic, also known as the concordance index (C-index), is widely used in clinical research to assess the discriminative ability of risk prediction models. Its appeal lies in its intuitive interpretation and broad applicability, par...