Exploring heart rate variability as a biomarker for frailty: A narrative review [0.03%]
心率变异性的生物标记在脆弱性评估中的作用：综述研究
Luca Tagliafico,Silvia Ottaviani,Riccardo Balzano et al.
Luca Tagliafico et al.
Background: Frailty is defined as a state of increased vulnerability to stressors resulting from reduced physiological homeostasis. The need to identify biomarkers capable of offering insight into the biological underpinn...
Eosinophilic esophagitis: From pathophysiology to diagnosis, monitoring and treatment [0.03%]
嗜酸性食管炎：从发病机制到诊断、监测和治疗
Luisa Bertin,Emma Sirinic,Matteo Ghisa et al.
Luisa Bertin et al.
Background: Eosinophilic esophagitis (EoE) is a chronic, immune-mediated inflammatory disorder of the oesophagus that has transformed from a rarely recognized condition to one of the most common causes of dysphagia and fo...
MYH11 variants in thoracic aortic aneurysm pathophysiology: From bench to bedside [0.03%]
胸主动脉瘤发病机制中的MYH11基因变异：从实验研究到临床应用
Aria Atash,Barend M E Mees,Maarten J Cramer et al.
Aria Atash et al.
Background: Thoracic aortic aneurysms and dissections (TAAD) are life-threatening vascular disorders affecting the medial layer of the aortic wall, associated with high mortality when a rupture or dissection occurs. Thoug...
A nomogram for predicting in-hospital death in a multinational cohort of patients with takotsubo syndrome [0.03%]
预测 tako-tsubo 综合征住院死亡的 nomogram
Yuyi Chen,Amanda Chang,Fangyuan Cheng et al.
Yuyi Chen et al.
Background: An effective risk stratification model on hospitalized patients with takotsubo syndrome (TTS) helps guide treatment to mitigate adverse events and improve prognosis. We aimed to develop a nomogram for predicti...
Multicenter Study
European journal of clinical investigation. 2026 Apr;56(4):e70190. DOI:10.1111/eci.70190 2026
Mohamad Khalil,Georgy Baffy,Jerlin Stephy JohnBritto et al.
Mohamad Khalil et al.
Background: Cholecystectomy is one of the most commonly performed abdominal surgical procedures and is considered the gold standard for symptomatic gallstone disease. Removing the gallbladder, however, is not a neutral pr...
Liver disease in management and outcomes of European and Asian patients with atrial fibrillation: A report from two observational prospective registries [0.03%]
肝病对欧洲和亚洲房颤患者管理及预后的影响——来自两个前瞻性观察性登记处的报告
Davide Antonio Mei,Tommaso Bucci,Giulio Francesco Romiti et al.
Davide Antonio Mei et al.
Background: In patients with atrial fibrillation (AF), the impact of liver disease (LD) on oral anticoagulant (OAC) prescription and outcomes remains unclear, as well as possible differences between European and Asian pop...
Observational Study
European journal of clinical investigation. 2026 Apr;56(4):e70193. DOI:10.1111/eci.70193 2026
Patient-reported outcomes in internal medicine: Methodological considerations for valid measurement and interpretation [0.03%]
内科医疗中的患者报告结果指标：有效测量与解读的方法学考虑因素
Carmine Zoccali,Giovanni Tripepi
Carmine Zoccali
Patient-reported outcome measures (PROMs) have become essential in contemporary internal medicine, where chronic, multisystem diseases and comorbidities make traditional biomedical endpoints insufficient as sole indicators of therapeutic be...
Infectious seeds of valve calcification: Exploring the bacterial hypothesis in the pathogenesis of calcific aortic valve disease [0.03%]
瓣膜钙化的传染性种子：探讨细菌假说在钙化主动脉瓣病发病机制中的作用
Antonella Forlino,Paola Giordani,Cristina Merla et al.
Antonella Forlino et al.
Background: Calcific aortic valve disease (CAVD) is a multifactorial condition characterized by progressive leaflet calcification with a potential role for bacterial colonization in its pathogenesis. This study investigat...
Observational Study
European journal of clinical investigation. 2026 Mar;56(3):e70188. DOI:10.1111/eci.70188 2026
Rahul Aggarwal,Deepak L Bhatt
Rahul Aggarwal
Background: Clinical trials are an important part of evidence generation in medicine but remain burdened by escalating costs, inefficiencies and manual processes. Artificial intelligence (AI) has emerged as a promising ap...