Sex differences in cholesterol metabolism and their association with SCORE2 cardiovascular risk based on cholesterol homeostasis markers and principal component analysis [0.03%]
基于胆固醇稳态标志物和主成分分析的性激素差异对SCORE2心血管风险的影响研究
Sandra Vladimirov,Tamara Gojković,Nataša Bogavac-Stanojevic et al.
Sandra Vladimirov et al.
Background: Sex-related differences in cholesterol metabolism may influence cardiovascular disease risk and outcomes. Understanding these differences in the context of SCORE2 predicted cardiovascular risk could support th...
Atherogenic dyslipidaemia and residual cardiovascular risk: Understanding the link to heart disease [0.03%]
致动脉粥样硬化性脂质异常和心血管残余风险：了解其与心脏病的联系
Gabriela O Girón,Sergi Otero,Panagiota Efstathia Nikolaou et al.
Gabriela O Girón et al.
Background: A significant proportion of patients continue to experience cardiovascular (CV) events despite achieving recommended low-density lipoprotein cholesterol (LDL-C) targets, a phenomenon referred to as residual CV...
Albumin, urea-to-albumin ratio, or the albumin-to-creatinine ratio to predict outcomes in heart failure with mildly reduced ejection fraction [0.03%]
预测射血分数轻度降低的心力衰竭患者预后的白蛋白、尿素与白蛋白比值或白蛋白与肌酐比值研究
Alexander Schmitt,Ibrahim Akin,Marielen Reinhardt et al.
Alexander Schmitt et al.
Background: This study investigates the prognostic impact of albumin, the urea-to-albumin ratio (UAR), and albumin-to-creatinine ratio (ACR) in patients with heart failure with mildly reduced ejection fraction (HFmrEF), s...
Cellular senescence in giant cell arteritis and polymyalgia rheumatica: From mechanisms to therapeutic opportunities [0.03%]
巨细胞动脉炎和多肌炎风湿症中的细胞衰老：从机制到治疗机会
Yiting Luo,Fan Yang,Yanlin He et al.
Yiting Luo et al.
Background: Giant cell arteritis (GCA) and (PMR) are inflammatory rheumatic disorders whose pathogenesis are unclear. The interleukin (IL)-6 receptor inhibitor is the first approved biologic agent for GCA and PMR, reducin...
Reversing frailty: The transformative effects of structured physical-activity-based physiotherapy on physical, cognitive and emotional health in older adults-An evidence-based systematic review [0.03%]
逆转衰老：基于结构化身体活动的物理治疗对老年人身心健康的影响——一项循证系统综述
Moattar Raza Rizvi,Ankita Sharma,Faizan Z Kashoo et al.
Moattar Raza Rizvi et al.
Background: Elderly frailty is a multifaceted clinical condition with diminished physiological reserves and increased stress susceptibility. It increases disability, hospitalization and mortality rates, requiring multidom...
HDL function and composition in atherothrombotic cardiovascular disease with very high HDL-C [0.03%]
极高高密度脂蛋白胆固醇水平动脉粥样硬化性心血管病患者的功能及组分特点
Teresa Padro,Natàlia Muñoz-García,Marta Fanlo-Maresma et al.
Teresa Padro et al.
Background: Emerging evidence demonstrates a J-shaped relationship between HDL-C levels and atherosclerotic cardiovascular disease (ASCVD) with very high HDL-C concentrations paradoxically associated with increased ASCVD ...
Harnessing controlled human infection models to accelerate vaccine development for neglected tropical diseases: Lessons from leishmaniasis [0.03%]
利用控制的人类感染模型加速被忽视的热带病疫苗研发：利什曼病的经验教训
Vivak Parkash
Vivak Parkash
Background: Controlled Human Infection Models (CHIMs) offer a powerful approach to expedite vaccine development by enabling early evaluation of vaccine candidate efficacy and immune responses. Their role is increasingly r...
Mapping Alzheimer's disease heterogeneity with molecular imaging biomarkers [0.03%]
利用分子影像生物标志物绘制阿尔茨海默病的异质性图谱
Elif Harput,Cecilia Boccalini,Gregory Mathoux et al.
Elif Harput et al.
Background: Alzheimer's disease (AD) is neuropathologically defined by the buildup of misfolded proteins such as extracellular amyloid-β (Aβ) and intracellular tau neurofibrillary tangles. AD also extends beyond these p...
Real-world evidence and observational studies: Methodological challenges in clinical research [0.03%]
真实世界证据和观察性研究：临床研究中的方法学挑战
Carmine Zoccali,Giovanni Tripepi
Carmine Zoccali
The emergence of real-world evidence (RWE) has significantly broadened the scope of clinical research in internal medicine, providing insights that extend beyond the constraints of randomized controlled trials (RCTs). RWE is generated from ...
Adipose tissue metabolomics identifies disease stage and tumour invasiveness of rectal cancer [0.03%]
脂肪组织代谢组学确定直肠癌的疾病阶段和肿瘤侵袭性
Lidia Cornejo Fernández,Laura Gallardo-Nuell,Anna Pigem Rodeja et al.
Lidia Cornejo Fernández et al.
Backgorund: Adipose tissue has emerged as a prognostic factor in rectal cancer (RC), yet its metabolic role in tumour progression remains poorly understood. This study aims to characterise the metabolic profiles of subcut...