Pulse Wave Velocity, Mortality and Cardiovascular Disease in Chronic Kidney Disease: A Systematic Review and Meta-Analysis [0.03%]
慢性肾脏病患者脉搏波速度、全因死亡率及心血管疾病关系的系统评价和 meta 分析
Carlos Pascual-Morena,Silvana Patiño-Cardona,Miriam Garrido-Miguel et al.
Carlos Pascual-Morena et al.
Background: Chronic kidney disease (CKD) is associated with high cardiovascular morbidity and mortality, which is mediated by arterial stiffness. Pulse wave velocity (PWV), as measured by the aortic (aPWV), brachial-ankle...
Benefits of Dietary Nitrate in Cognitive Decline Associated With Type 2 Diabetes: Pathways and Therapeutic Potential [0.03%]
膳食硝酸盐在2型糖尿病相关认知下降中的益处：途径和治疗潜力
Joao S Gonçalves,Ana Marçal,João Laranjinha et al.
Joao S Gonçalves et al.
Background: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance and hyperglycaemia, which are associated with a high risk of developing several complications, including cogn...
Ferroptosis-Associated Fibroblast Activation and Transcriptional Remodelling in Human Heart Failure: A Proof-of-Concept Study [0.03%]
人的心力衰竭中与铁死亡相关的成纤维细胞活化和转录重塑的概念证明研究
Konstantinos I Karampinos,Georgios Georgiopoulos,Marinos Kallikourdis et al.
Konstantinos I Karampinos et al.
Single-cell analysis of human heart failure identifies a fibroblast-enriched ferroptosis signature that distinguishes DCM from controls and reveals a pseudotime trajectory linking ferroptotic stress to progressive fibroblast activation and ...
Establishing a Zebrafish Functional Assay to Assess the Pathogenicity of Variants of Uncertain Significance in Ciliopathies [0.03%]
建立斑马鱼功能测定法以评估纤毛病中不确定意义变异的致病性
Carla Aresi,Francesca Tonelli,Concetta Mazzotta et al.
Carla Aresi et al.
A zebrafish morpholino knockdown model targeting ahi1 enables efficient phenotypic assessment of ciliopathy-related defects and functional evaluation of variants of uncertain significance. This assay clarifies the impact of VUSs, supporting...
Iron Status, Erythropoietin, and Cancer Incidence in the General Population [0.03%]
铁状态、促红细胞生成素和普通人群的癌症发病率
Siem J van Alfen,Pien Rawee,Li Luo et al.
Siem J van Alfen et al.
Background: Iron is essential for cellular function and cancer growth. While iron imbalance has been implicated in cancer development, epidemiological evidence remains inconsistent. Erythropoietin (EPO) may influence tumo...
A Comprehensive Meta-Analysis of Bioadaptor Versus Drug-Eluting Stents in Randomised Trials With Exploratory Single-Arm Landmark Analyses [0.03%]
生物可降解支架与药物洗脱支架的系统性meta分析及单组界标探索分析：来自随机对照试验的结果
Simon Wölbert,Stephanie Kühne,Andrea Patrignani et al.
Simon Wölbert et al.
Background: Late adverse events after percutaneous coronary intervention continue to occur beyond the first year with last-generation drug-eluting stents (DES). The coronary bioadaptor marks a new approach with an uncagin...
Bruna Spolador de Alencar Silva,Amanda Veiga Sardeli,Ricardo R Agostinete et al.
Bruna Spolador de Alencar Silva et al.
Background: It is commonly assumed that aging and chronic low-grade inflammation compromise adaptive immunity, particularly the function and metabolism of CD4+ T cells. The preceding are key regulators of immune responses...
Metagenomic profiling of bile in malignant cholestasis: Analysis of samples collected during EUS-guided biliary drainage [0.03%]
内镜超声引导下胆道引流采集样本的胆汁宏基因组分析
Łukasz Krupa,Georges P Schmarz,Robert Staroń et al.
Łukasz Krupa et al.
Identification of miR-150-5p in Human Amniotic Membrane Mesenchymal Cell-Derived Extracellular Vesicles as a Novel Mechanism Driving Cardioprotection [0.03%]
人羊膜间充质细胞源性外泌体中miR-150-5p的鉴定：一种新的心脏保护作用机制
Nunzio Alcharani,Laura Tesoro,Javier Díez-Mata et al.
Nunzio Alcharani et al.
Background: Human amniotic membrane mesenchymal stem cells (hAMSCs) hold strong cardioprotective potential, yet their mechanisms of action remain largely elusive. ...
FNDC4 and FNDC5 Attenuate SARS-CoV-2 S1-Induced Inflammatory Responses in Human Adipose Tissue [0.03%]
新型冠状病毒S1刺突蛋白诱导的炎性反应被FNDC4和FNDC5抑制
Gabriela Neira,Julia Hernández-Castañeda,Victoria Catalán et al.
Gabriela Neira et al.
Background: Adipose tissue is recognised as a SARS-CoV-2 reservoir and potential infection site. We herein characterised SARS-CoV-2 entry points in visceral (VAT) and subcutaneous (SAT) adipose tissue from people with obe...