Case Series on the Efficacy of Daratumumab in Treating Patients with Anti-Interferon-Gamma Autoantibodies [0.03%]
达托珠单抗治疗干扰素γ自身抗体患者的疗效系列报道
Ky-Lyn Tan,Hari Chandana Ghanta,Lucinda Blake et al.
Ky-Lyn Tan et al.
Deleterious germline CARD11 gain-of-function variants alter human B-cell and CD4+ T-cell differentiation and function [0.03%]
CARD11生殖系_GAIN_OF_FUNCTION_变异改变人类B细胞和CD4+_T细胞的分化和功能
Tina Nguyen,Melissa A Kallarakal,Jackie L Ludgate et al.
Tina Nguyen et al.
Introduction: CARD11 is a scaffold protein expressed primarily in hematopoietic tissues, shaping key processes in B and T cells via regulation of Ag-linked signaling pathways including NF-κB, mTOR, JNK, and AKT. Heterozy...
Clinical, Genetic, and Functional Characterization of Novel NFKB1 Variants in Chinese Patients with Primary Immunodeficiency [0.03%]
中国原发性免疫缺陷病患者中NFKB1新变异位点的临床、基因及功能特征分析
Jingyuan Zhang,Huacong Cai,Tienan Zhu et al.
Jingyuan Zhang et al.
Introduction: The nuclear factor κB (NF-κB)-related disorders encompassed not only common variable immunodeficiency but also manifestations of autoinflammation, autoimmunity, and malignancies. While most cases have been...
Bispecific MASP-2/3 Antibody Provides Superior Renoprotection Over Monotherapy in Pristane-Induced Lupus Nephritis [0.03%]
双特异性MASP-2/3抗体比单药治疗在石蜡油诱导的狼疮性肾炎中提供更佳的肾脏保护作用
Tianqi Tu,Chuqiao Wang,Zhong Li et al.
Tianqi Tu et al.
Introduction: Lupus nephritis (LN) is a major cause of organ damage in systemic lupus erythematosus (SLE) and is driven in part by overactivation of the lectin pathway (LP) and alternative pathway (AP) of complement. Mann...
Optimisation of a parallel CAR for B-cell lymphoma via ITAM attenuation and target specificity validation [0.03%]
通过ITAM下调和靶点特异性验证优化用于B细胞淋巴瘤的并行CAR
Fahima Kausar,Christopher Davis,Daniel Larcombe-Young et al.
Fahima Kausar et al.
Introduction: Second generation CAR T-cells have transformed the management of B-cell malignancy. However, in vivo functional persistence is often limiting, highlighting a key mechanism of treatment failure. ...
Aagat Khatiwada,Mohammed Elkrim Mohammed,Ingrid E Dumitriu et al.
Aagat Khatiwada et al.
Cholesteatoma is abnormal epithelial tissue in the middle ear cleft and an important cause of chronically discharging ears and hearing loss. Its proximity to important middle ear structures and the brain can lead to significant complication...
Immunometabolism crosstalk between regulatory T cells and glucose homeostasis of type 1 diabetes [0.03%]
调节性T细胞与1型糖尿病血糖稳态的免疫代谢交叉谈话机制
Masoume Nodehi,Ziba Veisi Malekshahi,Ramin Rahimnia et al.
Masoume Nodehi et al.
Type 1 diabetes mellitus (T1D) is an autoimmune disease that is associated with the loss of pancreatic β cells. Regulatory T cells (Tregs) play a critical role in the maintenance of immune tolerance; however, the number and function of Tre...
Depletion and recovery of IgG following treatment with an anti-FcRn antibody and IdeS in pigtail macaques [0.03%]
用于猪尾猕猴的抗FcRn抗体和IdeS治疗后的IgG消耗与恢复
Kara M Rzasa,Joanna Zikos,Toni Penney et al.
Kara M Rzasa et al.
Introduction: Antibodies are central players in adaptive immunity, providing protection against a wide array of pathogens through mechanisms such as neutralization, opsonization, recruitment of effector immune cells, comp...
CD137 deficiency patients: two new patients and review of the literature [0.03%]
CD137缺陷患者：2例新病例及文献回顾
Zehra Genc Ozbay,Busra Kocali,Deniz Ilgun Gurel et al.
Zehra Genc Ozbay et al.
CD137 (4-1BB, TNFRSF9) plays a crucial role in T-cell activation, proliferation, and antiviral immunity. Biallelic TNFRSF9 variants cause CD137 deficiency, a rare inborn error of immunity characterized by Epstein-Barr virus (EBV)-induced he...
A bioluminescent inhibition immunoassay for detecting GM-CSF inhibitory activity in serum [0.03%]
一种检测血液中GM-CSF抑制活性的生物发光抑制免疫测定法
Peter Bradhurst,Alex Stoyanov,Lindsey B Rosen et al.
Peter Bradhurst et al.
Introduction: Autoantibodies against Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) are the cause of autoimmune pulmonary alveolar proteinosis (aPAP). They are also found in the serum/plasma of previously immun...