Peripheral Immune Biomarkers Associated with Response to Adoptive Cell Therapy with Tumor Infiltrating Lymphocytes [0.03%]
与肿瘤浸润淋巴细胞过继细胞治疗反应相关的外周免疫生物标志物
Cecilie Oelvang Madsen,Marta Velasco Santiago,Evelina Martinenaite et al.
Cecilie Oelvang Madsen et al.
Adoptive cell therapy (ACT) with ex-vivo expanded tumor-infiltrating lymphocytes (TILs, TIL-ACT) has shown clinical efficacy in a significant proportion of patients with metastatic melanoma. To further target TIL-ACT towards responsive pati...
Discovery and Phase 1 study of a novel monoclonal antibody against human IL-1β for the treatment of IL-1β-mediated diseases [0.03%]
新型人IL-1β单克隆抗体的发现及其一期研究用于治疗由IL-1β介导的疾病
Minseon Cho,Susan H Tam,Lihua Shi et al.
Minseon Cho et al.
Interleukin-1β (IL-1β) is a key mediator of innate immunity against pathogen infections. However, dysregulated IL-1β activity is associated with various autoinflammatory, autoimmune, degenerative, atherosclerotic diseases, and cancers. B...
Nck1 regulates the in vitro development of human regulatory T cells through AKT pathway [0.03%]
Nck1通过AKT信号通路调控人调节性T细胞的体外发育
Aussanee Nuiyen,Donruedee Sanguansermsri,Jarun Sayasathid et al.
Aussanee Nuiyen et al.
T cell receptor (TCR) signalling is crucial in determining the fate of thymocyte differentiation in the thymus. The high-avidity interaction between TCR and self-peptide-MHC complexes induces development of regulatory T cells (Tregs), linea...
The role of IgA and IgG in Mycobacterium tuberculosis infection: A cross-sectional study in Ethiopia [0.03%]
IgA和IgG在结核分枝杆菌感染中的作用：来自埃塞俄比亚的横断面研究
Rubiyat E Islam,Meaza Zewdie,Daniel Mussa et al.
Rubiyat E Islam et al.
Introduction: Despite the high global prevalence of Mycobacterium tuberculosis (Mtb) infection in humans, most infected individuals achieve a stable immunological equilibrium, without showing clinical signs and symptoms o...
Characterization of T-bet expressing B cells in lupus patients indicates a putative prognostic and therapeutic value of these cells for the disease [0.03%]
狼疮患者中T-bet表达的B细胞的特征表明这些细胞对疾病具有潜在的预后和治疗价值
Athanasios Sachinidis,Maria Trachana,Anna Taparkou et al.
Athanasios Sachinidis et al.
Objective: To investigate whether T-bet+ B cells, as well as age-associated B cells/ABCs (CD19+CD21-CD11c+T-bet+) and double-negative B cells/DN (CD19+IgD-CD27- CXCR5-T-bet+), serve as prognostic and/or therapeutic tools ...
Application of Whole-Exome Sequencing to Predict Inborn Errors of Immunity in Pediatric Severe Infections and Sepsis [0.03%]
全外显子组测序在儿科重症感染及脓毒症中预测先天性免疫缺陷的应用
Abderrahmane Moundir,Ouissal Aissaoui,Nassima Akhrichi et al.
Abderrahmane Moundir et al.
Introduction: Increasing evidence supports the involvement of inborn errors of immunity (IEI) in severe infections, but little is known about the prevalence of these genetic defects in children with sepsis. Due to the lim...
How do large scale population studies inform vaccine evaluations in England? [0.03%]
英国的大规模人口研究是如何影响疫苗评估的？
Freja Kirsebom,Victoria Hall,Julia Stowe
Freja Kirsebom
Large scale population studies are important to monitor and evaluate aspects of a vaccination programme including vaccine coverage, real-world effectiveness, and post-licensure vaccine safety. These types of epidemiological studies often co...
Functional validation of a novel STAT3 'variant of unknown significance' identifies a new case of STAT3 GOF Syndrome and reveals broad immune cell defects [0.03%]
一个新型STAT3“意义未明变异体”的功能验证鉴定出一例新的STAT3激活型综合症病例并揭示了广泛的免疫细胞缺陷
Joseph Mackie,Daniel Suan,Peter McNaughton et al.
Joseph Mackie et al.
Introduction: STAT3 orchestrates crucial immune responses through its pleiotropic functions as a transcription factor. Patients with germline monoallelic dominant negative or hypermorphic STAT3 variants, who present with ...
B cells recruitment promotes M2 macrophage polarization to inhibit inflammation during wound healing [0.03%]
B细胞募集促进M2型巨噬细胞极化以抑制伤口愈合过程中的炎症反应
Yuye Yin,Shusheng Wu
Yuye Yin
Introduction: Wound healing causes heavy economic burdens for families and society, becoming a critical issue in the global healthcare system. While the role of immune cells in the wound healing process is well-establishe...