Type I Interferon Signature: a Quantitative Standardized Method for Clinical Application [0.03%]
I型干扰素特征：临床应用中的定量标准化方法
Alessandra Tesser,Paola Bocca,Massimiliano Ulivi et al.
Alessandra Tesser et al.
Type I Interferon (IFN) induced gene expression analysis ("IFN signature") is employed to categorize pathological conditions that exhibit type I IFN dysregulation and to direct customized therapeutic strategies. For instance, it is used to ...
Pirfenidone alleviates interstitial lung disease in mice by inhibiting neutrophil extracellular trap formation and NLRP3 inflammasome activation [0.03%]
吡非尼酮通过抑制中性粒细胞胞外诱捕网形成和NLRP3炎性体活化来缓解小鼠的间质性肺疾病
Qiyan Su,Yingyue Feng,Jin Guo et al.
Qiyan Su et al.
Background: Idiopathic inflammatory myopathy (IIM) is a progressive autoimmune disease characterized by interstitial lung disease (ILD) with limited therapeutics available. Pirfenidone (PFD), a medication utilized for the...
Admir Öztürk,Lara Yağcı,Serdal Ugurlu
Admir Öztürk
Deficiency of adenosine deaminase 2 (DADA2) has been a challenging diagnosis to make since it was first described in 2014. The disease represents a wide range of phenotypes. Therefore, it may present with various clinical patterns. Througho...
In-depth immune profiling of a patient with immunodeficiency, centromeric instability, and facial anomalies syndrome type 2 caused by a novel mutation in ZBTB24 [0.03%]
具有由ZBTB24中的新突变引起的免疫缺陷，着丝粒不稳定和面部异常综合症2的患者的深度免疫谱分析
Colleen M Roark,Diana Ramírez-Vásquez,Jenniffer Yissel Giron Martinez et al.
Colleen M Roark et al.
Immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome is a rare genetic disorder characterized by immunodeficiency and chromosomal instability. Mutations in DNA methylation genes such as DNMT3B (ICF1), ZBTB24 (ICF2)...
FcγRIIB (CD32B) antibodies enhance immune responses through activating FcγRs [0.03%]
FcγRIIB（CD32B）抗体通过激活Fcγ受体来增强免疫反应
Alexander P Simpson,Robert J Oldham,Kerry L Cox et al.
Alexander P Simpson et al.
Fc receptors (FcR) play a key role in coordinating responses from both the innate and adaptive immune system. The inhibitory Fc gamma receptor (FcγRIIB/CD32B; referred to as FcγRII in mice) restrains the immune response, specifically thro...
Intratumoral Injection of R848 and Poly(I:C) Synergistically Promoted Antitumour Immune Responses by Reprogramming Macrophage Polarization and Activating DCs in Lung Cancer [0.03%]
肺肿瘤内注射R848和poly(I:C)通过重新编程巨噬细胞极化和激活DCs协同促进抗肿瘤免疫反应
Shuanghui Chen,Linzhao Li,Haohua Yuan et al.
Shuanghui Chen et al.
Introduction: Immunotherapy has rapidly become a primary treatment option for many lung cancer patients because of its success in treating this prevalent and deadly disease. However, the success of immunotherapy relies on...
Unveiling WHIM syndrome: Mavorixafor's Emerging Role in Immune Restoration and Therapy [0.03%]
揭示WHIM综合症：Mavorixafor在免疫恢复和治疗中的新兴作用
Muhammad Sohaib Khan,Bismah Azeem,Ashir Kanwal et al.
Muhammad Sohaib Khan et al.
WHIM syndrome is a rare autosomal dominant immunodeficiency disorder and is an abbreviation formed from the initial letters of its main clinical presentations: Warts, Hypogammaglobulinemia, Infections, and Myelokathexis. It stems mainly fro...
Dynamic changes of host immune response during Helicobacter pylori-induced gastric cancer development [0.03%]
幽门螺旋杆菌诱导胃癌进程中宿主免疫反应的动态变化
Weiwei Fu,Xiurui Han,Xinyu Hao et al.
Weiwei Fu et al.
Introduction: Helicobacter pylori infection is the main risk factor for gastric cancer. Chronic inflammation is usually induced by H. pylori infection and is accompanied by inherent immune disorders. However, the dynamic ...
Understanding Immunological insights of Liver Transplantation: A practice for attaining Operational Tolerance [0.03%]
理解肝脏移植的免疫学认识：达到操作性耐受的实践方法
Geethanjali Dhayanithy,Subathra Radhakrishnan,Catherine Ann Martin et al.
Geethanjali Dhayanithy et al.
Liver transplantation has been at the forefront of medical research, with efforts concentrated on understanding the intricate cellular and molecular dynamics involved this complex procedure. This body of work has chronicled critical clinica...
The small molecule inhibitor 3PO is a modulator of neutrophil metabolism, ROS production and NET release [0.03%]
小分子抑制剂3PO是中性粒细胞代谢、ROS生成和NET释放的调节因子
Michele Fresneda Alarcon,Genna Ali Abdullah,Andy Nolan et al.
Michele Fresneda Alarcon et al.
Neutrophils are key effector leukocytes of the innate immune system and play a pivotal role in defending the host against microbial infections. Recent studies have identified a crucial link between glycolysis and neutrophil cellular functio...