The Pathophysiology of Hemophagocytic lympho-histiocytosis (HLH) syndrome and insights from animal models [0.03%]
噬血细胞综合征（HLH）的病理生理及动物模型研究进展
Sayan Mukherjee,Puneet Kumar
Sayan Mukherjee
Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory syndrome characterized by an aberrant immune response against host tissues. It can arise from diverse triggers like infection, inflammation, malignancy, genetic defects,...
Engaging PD-1 rescues regulatory T cell function and inhibits inflammatory T cells in rheumatoid arthritis [0.03%]
PD-1的激活可增强调节性T细胞功能并抑制炎症T细胞在类风湿关节炎中的作用
Kaustav Chowdhury,Uma Kumar,Jaydeep Chaudhuri et al.
Kaustav Chowdhury et al.
Background: Despite their synovial enrichment Regulatory T cells (Treg) fail to alleviate the joint inflammation in rheumatoid arthritis (RA). This indicates their functional impairment in the synovial milieu of RA patien...
Eleanor Karp-Tatham,Julian C Knight,Alexandre Bolze
Eleanor Karp-Tatham
The human response to vaccination exhibits considerable variability due to a complex interplay of heritable and environmental factors. This review examines the current understanding of the role of human genetics in vaccine responses, encomp...
Chronic Granulomatous disease: Lessons in Cell Biology From Monogenic Immunodeficiency [0.03%]
慢性肉芽肿病：单基因免疫缺陷的细胞生物学启示
Paige M Mortimer,Shuli Svetitsky,David C Thomas
Paige M Mortimer
Reactive oxygen species (ROS) are produced in immune cells by the phagocyte NADPH oxidase (NOX2) system that carries out coordinated transfer of electrons to molecular oxygen. The importance of the system in host defence and immunoregulatio...
1-methyl-tryptophan improves anxiety-like behavior in colitis mice by inhibiting neuroinflammation, promoting cell regeneration and decreasing apoptosis [0.03%]
1-甲基色氨酸通过抑制神经炎症、促进细胞再生和减少凋亡来改善结肠炎小鼠的类似焦虑行为
Li-Ping Zhao,Lu-Lu Tan,Yi-Meng Xia et al.
Li-Ping Zhao et al.
Introduction: Mood disorders such as anxiety are important extra-intestinal manifestations of inflammatory bowel disease (IBD), and are more prevalent in active IBD. Studies have shown that pharmacologically-induced anxie...
Pharmacodynamic effect of mTOR inhibition-based immunosuppressive therapy on dendritic cell and natural killer cell subsets after renal transplantation [0.03%]
基于mTOR抑制的免疫抑制疗法对肾移植后树突状细胞和自然杀伤细胞亚群的药效学效应研究
Sabine Weber,Xinyi Wei,Guixia Chen et al.
Sabine Weber et al.
Background: mTOR inhibitor therapy is solely monitored via pharmacokinetics after kidney transplantation, which may not accurately reflect the effectiveness of PI3K-Akt-mTOR pathway blockade, potentially leading to inadeq...
Prospective analysis of the number and function of two T regulatory cell subsets in healthy individuals [0.03%]
健康人两组T细胞亚群数量和功能的前瞻性分析
Erick Colunga-Bolaños,Lesly Doniz-Padilla,Marlen Vitales-Noyola et al.
Erick Colunga-Bolaños et al.
Introduction: T regulatory (Treg) cells play a crucial role in immune system homeostasis and in the pathogenesis of immune-mediated inflammatory diseases. Accordingly, numerous studies have examined the number and functio...
Clinical and experimental treatment of residual immune activation in people living with HIV [0.03%]
艾滋病病毒感染者的残存免疫激活的临床和实验治疗
Krystelle Nganou-Makamdop
Krystelle Nganou-Makamdop
Potent inflammatory responses stemming from innate and T cell activation are initiated during acute human immunodeficiency virus (HIV) infection. Suppression of the virus replication by antiretroviral therapy reduces but does not normalize ...
Sulforaphane relieved inflammation symptoms in EAP mice by blocking oxidative stress and NLRP3 inflammasome activation through the Nrf2 pathway [0.03%]
萝卜硫素通过Nrf2信号通路阻断氧化应激和NLRP3炎症小体激活缓解早幼粒白血病细胞异种移植小鼠的炎性症状
Tong Meng,Rui Feng,Yunlong Zhu et al.
Tong Meng et al.
Chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS) are diagnosed in patients with various pelvic or genitourinary symptoms irrespective of the presence of a tender prostate. The etiology of chronic nonbacterial prostatitis remai...
Dan Tomomasa,Madoka Nishimura,Ayami Ohya et al.
Dan Tomomasa et al.
Introduction: Deficiency of X-linked inhibitor of apoptosis protein (XIAP) is an X-linked recessive inborn error of immunity characterized by abnormal immune responses leading to inflammatory bowel disease and hemophagocy...