Unravelling the Pathogenesis of Eosinophilic Esophagitis from Genetic Predisposition to Environmental Triggers [0.03%]
从遗传易感性到环境触发因素解析嗜酸细胞性食管炎的发病机制
Sohail Aziz,Raffaele Pellegrino,Pietro Buono et al.
Sohail Aziz et al.
Eosinophilic esophagitis (EoE) is a chronic disease primarily driven by immune-mediated pathogenesis, characterized by eosinophil-driven inflammation of the oesophagus, leading to organ dysfunction and fibrosis. Although initially considere...
HLA-DR expressing lymph node fibroblasts maintain FoxP3+ regulatory T cells and are reduced in rheumatoid arthritis [0.03%]
风湿性关节炎中淋巴结成纤维细胞表达HLA-DR并维持FoxP3+调节T细胞
Aoife M O&#x;Byrne,Cristoforo Grasso,Charlotte M de Winde et al.
Aoife M O&#x;Byrne et al.
Introduction: Murine studies have demonstrated that lymph node fibroblasts can present self-antigens via major histocompatibility complex class II molecules, inducing functional regulatory T cells and contributing to peri...
The differential immunological impact of photon vs proton radiation therapy in high grade lymphopenia in patients with gastrointestinal tumors [0.03%]
高淋巴细胞减少型胃肠道肿瘤患者光子与质子放疗对免疫学不同影响的比较研究
James M Heather,Daniel W Kim,Sean M Sepulveda et al.
James M Heather et al.
Background: Radiation therapy has long been a cornerstone of cancer treatment. More recently, immune checkpoint blockade has also been applied across a variety of cancers, often leading to remarkable response rates. Howev...
Deletion of Thymic Myoid Cells Regulates the Thymic Microenvironment Involved in the Progression of Tumor-Associated Myasthenia Gravis [0.03%]
胸导管肌细胞的删除调节肿瘤相关重症肌无力进行过程中胸腺微环境
Bo Hu,Yang Luo,Xiangyu Ding et al.
Bo Hu et al.
Background: Myasthenia gravis (MG) is an autoimmune disease commonly associated with immune disorders in thymoma. The role of thymus myoid cells (TMCs) in the pathogenesis of autoimmune diseases has attracted much attenti...
An atypical adolescent case of leukocyte adhesion deficiency I caused by a novel ITGB2 splicing variant with successful immune reconstitution following hematopoietic stem cell transplantation [0.03%]
一个罕见的青少年ITGB2剪接变异导致的I型白细胞黏附缺陷病并成功接受造血干细胞移植后免疫重建的病例报告
Guanghua Zhu,Honghong Yue,Jianxin He et al.
Guanghua Zhu et al.
Leukocyte adhesion deficiency I (LAD-I) is an autosomal recessive immunodeficiency caused by mutations in the ITGB2 gene, characterized by recurrent severe infections, impaired pus formation, and delayed wound healing. In this study, we des...
Uncovering metabolic pathways in human alveolar macrophages in response to lipopolysaccharide [0.03%]
人肺泡巨噬细胞对脂多糖反应的代谢途径研究
Christine C A van Linge,Erik H A Michels,Liza Pereverzeva et al.
Christine C A van Linge et al.
Introduction: Alveolar macrophages (AMs) play an essential role in maintaining homeostasis in the lung and in innate immunity for host defense. To fuel inflammatory responses, AMs do not rely on glycolysis, but require ox...
Susanne Schiffmann,Marina Henke,Friedemann Weber et al.
Susanne Schiffmann et al.
Spindlin-1, a multivalent epigenetic reader, is a new target for cancer therapy. Beside the anticancer effect, modulation of the recognition of methyl marks of histones may impact the immune system, which plays an important role in the anti...
Dendritic cell dysfunction, including impaired IL-12 production, is associated with chronic pulmonary aspergillosis [0.03%]
树突细胞功能障碍（包括IL-12产生受损）与慢性肺曲霉病相关联
Stefano A P Colombo,Sara Gago,Mathilde Chamula et al.
Stefano A P Colombo et al.
Background: Growing evidence links immune dysfunction, notably impaired IFNγ production, to chronic pulmonary aspergillosis (CPA), but understanding of the immune phenotype in CPA patients remains limited. ...
Correction to: Essential role of interferon-regulatory factor 4 in regulating diabetogenic CD4+ T and innate immune cells in autoimmune diabetes in NOD mice [0.03%]
Correction to: IRF4在糖尿病易感NOD小鼠自身免疫反应中的调节作用
Published Erratum
Clinical and experimental immunology. 2025 Jan 21;219(1):uxaf032. DOI:10.1093/cei/uxaf032 2025
Complement factors as biomarkers in ANCA-associated vasculitis in remission [0.03%]
补体因子在ANCA相关性血管炎缓解期中的生物标志物作用
Rebecca Trattner,Maria Iordanou,Sophie Ohlsson et al.
Rebecca Trattner et al.
Background: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of rare, autoimmune diseases causing inflammation in the vessel wall. Many organs can be affected, and kidney involvement is a...