TREM2 Impedes Recovery After Spinal Cord Injury by Regulating Microglial Lysosomal Membrane Permeabilization-Mediated Autophagy [0.03%]
TREM2通过调节小胶质细胞溶酶体膜透化介导的自噬阻碍脊髓损伤后恢复
Tianlun Zhao,Jiawei Di,Yu Kang et al.
Tianlun Zhao et al.
Microglia, considered as the main immune responder, play an important role in regulating neuroinflammation in central nervous system (CNS) disorders. Our previous work found that TREM2 is highly expressed in microglia and is related to thei...
Hypertranscription of rDNA Responsible for Nucleolar Remodelling is a Doorman for Acquiring Pluripotency [0.03%]
rDNA超转录介导核仁重构是获得多能性的守护者
Yuchen Sun,Xinglin Hu,Xingwei Huang et al.
Yuchen Sun et al.
Ribosome biogenesis occurs within the nucleolus, with the initial step being the transcription of ribosomal DNA (rDNA). Although rDNA transcription is limited in somatic cells, it is more active in stem cells. Nevertheless, the mechanisms i...
Mechanistic Insights and Therapeutic Potentials of Ubiquitin-Proteasome System in Non-Small Cell Lung Cancer [0.03%]
泛素-蛋白酶体系统在非小细胞肺癌中的作用机制及治疗潜力
Guangyao Zhou,Jiaxiong Tan,Pengpeng Zhang et al.
Guangyao Zhou et al.
Non-small cell lung cancer (NSCLC) remains a leading cause of cancer mortality. Despite advancements in gene targeted therapies and immunotherapies, high heterogeneity contributes to limited efficacy and therapeutic resistance. Ubiquitinati...
THER: Integrative Web Tool for Tumour Hypoxia Exploration and Research [0.03%]
THER：肿瘤低氧状态的集成式网络工具用于探究和研究
Yasi Zhang,Huiying Liu,Pengpeng Zhang et al.
Yasi Zhang et al.
GANT61 Modulates Autophagy and Lipid Metabolism in Ovarian Cancer [0.03%]
GANT61在卵巢癌中的作用机制研究：调控自噬和脂代谢
Yibin Pan,Lingfeng Chen,Jinlu Shen et al.
Yibin Pan et al.
GANT61 induced autophagy via the AKT pathway and promoted the accumulation of lipid droplets in both cell lines. The molecular mechanism behind this lipid accumulation appears to involve the mediation of SREBP1. Furthermore, the combination...
Extrachromosomal Circular DNA in Cancer: Mechanisms and Clinical Applications [0.03%]
癌症中的细胞外环状DNA：机制及临床应用
Jiajia Li,Peng Luo,Zhengrui Li et al.
Jiajia Li et al.
Extrachromosomal circular DNA (eccDNA) has emerged as a critical area of cancer research due to its ubiquitous presence in tumour cells and significant role in tumorigenesis, progression and drug resistance. Recent studies demonstrate that ...
Synergistical Induction of Apoptosis via Cold Atmospheric Plasma and Nanohydroxyapatite for Selective Inhibition of Oral Squamous Cell Carcinoma in Tumour Microenvironment [0.03%]
冷等离子体和纳米羟基磷灰石协同诱导口腔鳞状细胞癌微环境选择性凋亡抑制作用研究
Wenting Qi,Hanghang Liu,Huaze Liu et al.
Wenting Qi et al.
Surgical resection, radiotherapy and chemotherapy are the primary strategies of treating cancers globally. However, the current treatment methods bring new disease burdens to patients due to postoperative complications and multiple side eff...
Elucidating the Role and Mechanism of Alpha-Enolase in Senescent Amelioration via Metabolic Reprogramming [0.03%]
代谢重编程介导的α-烯醇酶改善衰老的作用及机制研究
Yun Haeng Lee,Hyunwoong Lim,Gyungmin Kim et al.
Yun Haeng Lee et al.
Senescent cells are characterised by increased glycolysis dependence. Normalisation of glycolysis metabolism is essential for senescence amelioration. However, the mechanism of proteins involved in cellular glycolysis metabolism has not bee...
Mechanical Force Regulates the Paracrine Function of ADSCs to Promote the Adipose-Regenerating Effects of AAM by Regulating Angiogenesis and the Inflammatory Response [0.03%]
机械力通过调节血管生成和炎症反应促进ADSCs的旁分泌功能以增强AAM促脂肪再生的作用
Yining Wang,Luyu Zhang,Jiaxuan Liu et al.
Yining Wang et al.
Conditioned medium (CM), obtained by mechanical regulation of the paracrine activity of ADSCs, was fused with acellular adipose matrix (AAM) and methyl cellulose (MC) to synthesize a composite hydrogel which was grafted onto nude mice. The ...
Xukun Lyu,Jian Wang,Jiacan Su
Xukun Lyu
Osteoarthritis (OA) is the most prevalent degenerative joint disease worldwide, imposing a substantial global disease burden. However, its pathogenesis remains incompletely understood, and effective treatment strategies are still lacking. O...