Interleukin-10 Derived Apoptotic Vesicles Enhance Scarless Skin Healing by Modulating Fibroblast Metabolism and Fibrosis Pathways [0.03%]
白细胞介素10诱导的凋亡小体通过调节成纤维细胞代谢和增生途径促进无瘢痕修复
Yang Zou,Jinglun Zhang,Wenxuan Mao et al.
Yang Zou et al.
Open skin wounds caused by burns, trauma, or underlying diseases impose substantial clinical challenges and significantly compromise patients' quality of life due to their complex management and high risk of scarring. In this study, we expl...
Luteolin Inhibits NLRP3 Inflammasome Activation to Ameliorate DSS-Induced Colitis by Regulating AMPK Signalling [0.03%]
黄酮类化合物山柰素通过调节AMPK信号抑制NLRP3炎性小体的活化从而改善DSS诱导的结肠炎
Lianxiang Luo,Fangfang Huang,Guixuan Fang et al.
Lianxiang Luo et al.
Luteolin alleviates DSS-induced ulcerative colitis in mice by targeting the NLRP3 inflammasome, as it shows no effect in NLRP3-/- mice. It inhibits NLRP3 activation and IL-1β secretion in macrophages by reducing ROS, mtROS and calcium leve...
Ethical and Regulatory Considerations in the Clinical Translation of Pluripotent Stem Cell-Derived NK Cell Therapies [0.03%]
多能干细胞来源的NK细胞治疗临床转化的伦理和监管考量
Qianwen Chen,Jianwei Lv,Xinwei Xie et al.
Qianwen Chen et al.
Advancements in the generation of human pluripotent stem cell-derived natural killer (PSC-NK) cells have attracted considerable attention within the biomedical research community, offering a promising off-the-shelf technique for universal i...
LCN2-ACOD1 Signalling Affects the Post-Injury Regeneration of Skeletal Muscle Through Mediating Ferroptosis [0.03%]
LCN2-ACOD1信号通过介导铁死亡影响骨骼肌损伤后的再生修复反应
Xiaojing Hao,Hongwei Shi,Di Wu et al.
Xiaojing Hao et al.
The normal growth and development of skeletal muscle are crucial for the proper function of organisms. During myoblast development, cell death is a fundamental physiological process, and skeletal muscle damage involves various types of cell...
Chen-Chen Xie,Ting Wang,Xin-Ran Liu et al.
Chen-Chen Xie et al.
The malignant transformation of cancer cells is underpinned by the dysregulation of essential cellular processes, including genome stability maintenance, DNA repair, transcriptional control and signal transduction. These processes are not r...
Targeting the Secretin Receptor in Macrophages Attenuates Silica-Induced Pulmonary Fibrosis [0.03%]
targeting the分泌素受体在巨噬细胞中可减轻硅致肺纤维化
Yaqian Li,Tian Li,Fuyu Jin et al.
Yaqian Li et al.
Targeting macrophage SCTR mitigates integrated profibrotic, inflammatory, ER stress, and senescent pathways, preserving lung function and revealing a novel therapeutic strategy for silicosis. ...
Identification and Phylogenetic Characterisation of Novel Adeno-Associated Virus Capsids in Non-Human Primate Tissues [0.03%]
非人灵长类组织中新型腺相关病毒衣壳的鉴定和系统发育特征分析
Liyu Zhu,Kai Xu,Yali Ding et al.
Liyu Zhu et al.
Adeno-associated virus (AAV) has emerged as the predominant viral vector in clinical gene therapy. However, its widespread application confronts critical challenges, including pre-existing neutralising antibodies in 40%-80% of the populatio...
Non-Coding RNAs in Breast Cancer Radioresistance: Mechanisms, Functional Roles and Translational Potentials [0.03%]
放射抵抗的乳腺癌中的非编码RNA：机制、功能和转化潜能
Xiaohui Zhao,Yuting Qiu,Jie Chen et al.
Xiaohui Zhao et al.
Breast cancer remains the most prevalent malignancy among women, and radiotherapy plays a pivotal role in reducing local recurrence and improving prognosis. However, the emergence of radioresistance in a subset of patients significantly com...
PHGDH Orchestrates Cell Cycle Progression to Drive Cardiomyocyte Proliferation and Myocardial Regeneration via TGF-β/Smad Signalling Pathway [0.03%]
磷酸羟丙酸脱氢酶通过TGF-β / Smad信号通路调控细胞周期以促进心肌细胞增殖和心肌组织再生
Han Zhang,Li Zhang,Zehao Feng et al.
Han Zhang et al.
The mature mammalian heart has limited ability for self-repair and regeneration. Here, we establish phosphoglycerate dehydrogenase (PHGDH) as a crucial key for cardiomyocyte proliferation, with diminishing expression during postnatal cardia...