Liangzheng Chang,Lu Li,Yuling Han et al.
Liangzheng Chang et al.
Organoid technology, as a revolutionary biomedical tool, has shown immense potential in haematological research in recent years. By using three-dimensional (3D) cell culture systems constructed from pluripotent stem cells (PSCs) or adult st...
RETRACTION: CBX8 Interacts with Chromatin PTEN and Is Involved in Regulating Mitotic Progression [0.03%]
撤稿：CBX8与染色体PTEN相互作用并参与调节有丝分裂进程
B. H. Choi, T. M. Colon, E. Lee, Z. Kou, W. Dai, "CBX8 Interacts with Chromatin PTEN and Is Involved in Regulating Mitotic Progression," Cell Proliferation 54, no. 11 (2021): e13110. https://doi.org/10.1111/cpr.13110. The above article, pub...
Deciphering Age-Dependent ECM Remodelling in Liver: Proteomic Profiling and Its Implications for Aging and Therapeutic Targets [0.03%]
肝纤维化年龄依赖性重塑的蛋白质组学研究及潜在抗衰老和治疗靶点预测
Juan Liu,Qingru Song,Chen Li et al.
Juan Liu et al.
Aging is characterised by progressive structural and functional changes in the liver, with the extracellular matrix (ECM) playing a key role in modulating these changes. Our study presents a comprehensive proteomic analysis of the liver ECM...
YKT6 Is Essential for Male Fertility by Promoting Meiosis Progression During Spermatogenesis of Mice [0.03%]
YKT6通过促进小鼠精子发生过程中的减数分裂进程来维持雄性生育力
Jie Cen,Xiaochen Yu,Ziqi Wang et al.
Jie Cen et al.
SNARE proteins are required for membrane fusion events throughout the endomembrane system, and are therefore associated with vesicular transport. Here, we found that the SNARE family member, YKT6, is indispensable for male fertility in mice...
Min Zhou,Mei Zhou,Yang Jin
Min Zhou
Cell size is an important component of cell morphological characteristics. It reflects the characteristics of the cell type, nutritional status, growth stage and physiological function. The cell size of cells of the same type tends to be ho...
FKBP5 Mediates Alveolar Fibroblast Necroptosis During Acute Respiratory Distress Syndrome [0.03%]
FKBP5在急性肺损伤向急性呼吸窘迫综合征进展过程中调控肺泡纤维母细胞坏死性凋亡中的作用及机制研究
Dong Zhang,Wei Liu,Ting Sun et al.
Dong Zhang et al.
The inflammatory storm is a hallmark of acute respiratory distress syndrome (ARDS), yet effective therapies remain unavailable. FK506-binding protein 51 (FKBP5) has emerged as a regulator of inflammatory responses. In this study, FKBP5 expr...
Mechanism of EC-EXOs-Derived THBS3 Targeting CD47 to Regulate BMSCs Differentiation to Ameliorate Bone Loss [0.03%]
EC-EXOs衍生的THBS3靶向CD47调节BMSCs分化以改善骨质流失机制研究
Jiaojiao Wang,Zhaokai Zhou,Wenjie Chen et al.
Jiaojiao Wang et al.
With the continuous increase of the elderly population and the deepening of population ageing in China, osteoporosis has gradually become one of the significant public health problems. Elucidating the pathophysiological mechanisms that indu...
FAM20C Modulates Neuronal Differentiation in Hypoxic-Ischemic Brain Damage via KAP1 Phosphorylation and LINE1 RNA m6A-Dependent H3K9me3 Regulation [0.03%]
缺氧缺血性脑损伤中FAM20C通过KAP1磷酸化和LINE1 RNA m6A依赖的H3K9me3调节调控神经元分化
Chen-Xi Feng,Mei Wang,Gen Li et al.
Chen-Xi Feng et al.
Neurodevelopmental impairment due to hypoxic-ischemic brain damage (HIBD) lacks effective biomarkers and therapeutic targets. Based on some cues from published papers, extracellular serine/threonine protein kinase FAM20C was speculated to p...
Tryptophan Suppresses FTH1-Driven Ferritinophagy, a Key Correlate of Prognosis in Hepatocellular Carcinoma [0.03%]
色氨酸通过抑制FTH1驱动的铁死亡型自噬影响肝癌预后
Xinxiang Cheng,Xin Ge,Chi Zhang et al.
Xinxiang Cheng et al.
Hepatocellular carcinoma (HCC) remains a lethal malignancy with limited therapeutic options. Ferritinophagy, an autophagy-dependent process regulating iron metabolism, has emerged as a key contributor to ferroptosis and tumour progression. ...