Wedelolactone facilitates Ser/Thr phosphorylation of NLRP3 dependent on PKA signalling to block inflammasome activation and pyroptosis [0.03%]
wedelolactone通过PKA信号促进NLRP3的丝氨酸/苏氨酸磷酸化，从而阻止炎性小体活化和pyroptosis
Hao Pan,Yuqing Lin,Jianping Dou et al.
Hao Pan et al.
Objectives: Wedelolactone exhibits regulatory effects on some inflammatory diseases. However, the anti-inflammatory mechanism of wedelolactone has not been entirely unravelled. Therefore, the present study focuses on inve...
The lncRNA H19 binding to let-7b promotes hippocampal glial cell activation and epileptic seizures by targeting Stat3 in a rat model of temporal lobe epilepsy [0.03%]
长链非编码RNA H19通过结合let-7b促进海马胶质细胞活化及颞叶癫痫发作的研究
Chun-Lei Han,Yun-Peng Liu,Chen-Jia Guo et al.
Chun-Lei Han et al.
Objectives: Glial cell activation contributes to the inflammatory response and occurrence of epilepsy. Our preliminary study demonstrated that the long non-coding RNA, H19, promotes hippocampal glial cell activation durin...
Morroniside attenuates high glucose-induced BMSC dysfunction by regulating the Glo1/AGE/RAGE axis [0.03%]
苦杏仁苷通过调节Glo1/AGE/RAGE轴缓解高糖诱导的骨髓间充质干细胞功能障碍
Yi Sun,Yu Zhu,Xuanzhe Liu et al.
Yi Sun et al.
Objectives: High glucose (HG)-mediated bone marrow mesenchymal stem cell (BMSC) dysfunction plays a key role in impaired bone formation induced by type 1 diabetes mellitus (T1DM). Morroniside is an iridoid glycoside deriv...
Exosomes released from educated mesenchymal stem cells accelerate cutaneous wound healing via promoting angiogenesis [0.03%]
教育诱导的间充质干细胞释放的外泌体通过促进血管生成加速创面愈合
Xinyu Qiu,Jin Liu,Chenxi Zheng et al.
Xinyu Qiu et al.
Objectives: Skin serves as the major interface between the external environment and body which is liable to many kinds of injuries. Mesenchymal stem cell (MSC) therapy has been widely used and became a promising strategy....
Exopolysaccharide from Cryptococcus heimaeyensis S20 induces autophagic cell death in non-small cell lung cancer cells via ROS/p38 and ROS/ERK signalling [0.03%]
Cryptococcus heimaeyensis S20 的外多糖通过 ROS/p38 和 ROS/ERK 信号通路诱导非小细胞肺癌细胞发生自噬性死亡
Yao Hao,Yao Huang,Jingyi Chen et al.
Yao Hao et al.
Objectives: Cryptococcus heimaeyensis S20 is found in Antarctica and can produce exopolysaccharides (CHEPS). Here, we explore the anti-tumour effects of CHEPS on non-small cell lung cancer (NSCLC). ...
High-efficient generation of VCAM-1+ mesenchymal stem cells with multidimensional superiorities in signatures and efficacy on aplastic anaemia mice [0.03%]
高效的VCAM-1+间充质干细胞的产生及其在再生医学中的多维度优势标志和疗效研究——以再生障碍性贫血小鼠模型为例
Yimeng Wei,Leisheng Zhang,Ying Chi et al.
Yimeng Wei et al.
Objective: Longitudinal studies have indicated VCAM-1+ mesenchymal stem/stromal cells (MSCs) as promising resources in regenerative medicine, yet the abundance in gene expression is far from adequate in the advantaged and...
Chrysophanic acid shifts the differentiation tendency of BMSCs to prevent alcohol-induced osteonecrosis of the femoral head [0.03%]
没食子酸通过改变酒精所致骨髓间充质干细胞分化方向防治股骨头坏死
Hongping Yu,Pei Liu,Daoyu Zhu et al.
Hongping Yu et al.
Objectives: Osteonecrosis of the femoral head (ONFH), largely caused by alcohol abuse, is a refractory bone disease characterized by the impaired capacity of osteogenic differentiation of bone mesenchymal stem cells (BMSC...
Yichi Xu,Shuya Pan,Wenxiao Jiang et al.
Yichi Xu et al.
Cancer is one of most the significant threats to human health worldwide, and the primary method of treating solid tumours is surgery. Propofol, one of the most widely used intravenous anaesthetics in surgery, was found to be involved in man...
RNA processing genes characterize RNA splicing and further stratify colorectal cancer [0.03%]
RNA处理基因可表征RNA剪接并进一步对结直肠癌进行分层
Xiaofan Lu,Yujie Zhou,Jialin Meng et al.
Xiaofan Lu et al.
Objectives: Due to the limited evaluation of the prognostic value of RNA processing genes (RPGs), which are regulators of alternative splicing events (ASEs) that have been shown to be associated with tumour progression, t...
Targeting epidermal growth factor-overexpressing triple-negative breast cancer by natural killer cells expressing a specific chimeric antigen receptor [0.03%]
靶向表皮生长因子的三阴性乳腺癌的小分子免疫疗法
Yan Liu,Yehui Zhou,Kuo-Hsiang Huang et al.
Yan Liu et al.
Objectives: Traditional cancer therapy and regular immunotherapy are ineffective for treating triple-negative breast cancer (TNBC) patients. Recently, chimeric antigen receptor-engineered natural killer cells (CAR NK) hav...