KYNA Ameliorates Hepatic Ischemia-Reperfusion Injury by Activating the Hippo Signalling Pathway via FTO-Dependent m6A Demethylation of LATS1 [0.03%]
FTO依赖的LATS1 mRNA去甲基化激活Hippo信号通路介导KYNA改善肝缺血再灌注损伤
Wenjie Zheng,Xiaowen Wang,Haoqi Chen et al.
Wenjie Zheng et al.
Hepatic ischemia-reperfusion injury (HIRI) substantially influences the prognosis of liver transplant recipients. Although kynurenic acid (KYNA) has been associated with protective effects against ischemia-reperfusion injury in various orga...
Glutaminase-1 Mediated Glutaminolysis to Glutathione Synthesis Maintains Redox Homeostasis and Modulates Ferroptosis Sensitivity in Cancer Cells [0.03%]
谷氨酰胺酶-1介导的谷氨酰胺代谢促进谷胱甘肽合成以维持氧化还原平衡并调节癌细胞的铁死亡敏感性
Changsen Bai,Jialei Hua,Donghua Meng et al.
Changsen Bai et al.
Glutaminase-1 (GLS1) has garnered considerable interest as a metabolic target in cancer due to its heightened involvement and activity. However, the precise fate of glutaminolysis catalysed by GLS1 in cancer cells remains elusive. We found ...
Inhibition of Alkbh5 Attenuates Lipopolysaccharide-Induced Lung Injury by Promoting Ccl1 m6A and Treg Recruitment [0.03%]
ALKBH5抑制通过促进CCL1 mRNA去甲基化和Tregs募集减轻脂多糖诱导的肺损伤
Hongdou Ding,Xinnan Xu,Yaoyao Zhu et al.
Hongdou Ding et al.
This paper discussed the role of AlkB homologue 5 (Alkbh5) in the progression of lipopolysaccharide (LPS)-induced acute lung injury (ALI). LPS-induced ALI models were established in Alkbh5 knockout (KO) and knock-in (KI) mice. The m6A level...
IMPDH2's Central Role in Cellular Growth and Diseases: A Potential Therapeutic Target [0.03%]
次黄嘌呤单核苷酸磷酸核糖转移酶2在细胞增殖和疾病中的中心作用及其作为治疗靶点的潜力
Zheng Li,Yunpeng Zou,Jiayao Niu et al.
Zheng Li et al.
IMPDH2 is a rate-limiting enzyme in guanine nucleotide biosynthesis. It plays diverse roles in various physiological and pathological processes: nucleotide metabolism, inflammation, immune function, ribosomal stress. Structural or regulator...
Deciphering Sequence Determinants of Zygotic Genome Activation Genes: Insights From Machine Learning and the ZGAExplorer Platform [0.03%]
解读合子基因组激活基因的序列决定因素：来自机器学习和ZGAExplorer平台的启示
Jixiang Xing,Siqi Yang,Yuchao Liang et al.
Jixiang Xing et al.
The mammalian life cycle initiates with the transition of genetic control from the maternal to the embryonic genome during zygotic genome activation (ZGA), which becomes pivotal for development. Nevertheless, understanding the conservation ...
Revitalising Aging Oocytes: Echinacoside Restores Mitochondrial Function and Cellular Homeostasis Through Targeting GJA1/SIRT1 Pathway [0.03%]
姜黄素酸通过靶向GJA1/SIRT1通路恢复线粒体功能和细胞稳态以复活老化卵母细胞
Liuqing Yang,Xinle Lai,Fangxuan Lin et al.
Liuqing Yang et al.
As maternal age increases, the decline in oocyte quality emerges as a critical factor contributing to reduced reproductive capacity, highlighting the urgent need for effective strategies to combat oocyte aging. This study investigated the p...
Membraneless Organelles and Phase Separation in Tumours: Mechanisms and Prospects [0.03%]
无膜细胞器与肿瘤中的相分离：机制和前景
Hao Yang,Zhong Chu,Shuwen Han et al.
Hao Yang et al.
Membraneless organelles (MLOs) are a type of subcellular compartment structure discovered in eukaryotes in recent years. They are mainly formed through the liquid-liquid phase separation (LLPS) and aggregation of macromolecular substances s...
Lactate and Lactylation in AKI-to-CKD: Epigenetic Regulation and Therapeutic Opportunities [0.03%]
乳酸和乳酸化在急性肾损伤至慢性肾脏病中的表观遗传调控及治疗机会
Yi Hou,Dongwei Liu,Zuishuang Guo et al.
Yi Hou et al.
Lactate is not only a byproduct of glycolysis, but is also considered an energy source, gluconeogenic precursor, signalling molecule and protein modifier during the process of cellular metabolism. The discovery of lactylation reveals the mu...
RNF187 Facilitates Proliferation and Migration of Human Spermatogonial Stem Cells Through WDR77 Polyubiquitination [0.03%]
RNF187通过WDR77泛素化促进人类精原干细胞的增殖和迁移
Haoyue Hu,Xiaoxue Xi,Bing Jiang et al.
Haoyue Hu et al.
The E3 ubiquitin ligase RNF187, also known as RING domain AP1 coactivator-1, is a member of the RING finger family. RNF187 is indispensable for the proliferation and migration of GC-1 cells derived from mouse spermatogonia and GC-2 cells de...
Production and Functional Verification of 8-Gene (GGTA1, CMAH, β4GalNT2, hCD46, hCD55, hCD59, hTBM, hCD39)-Edited Donor Pigs for Xenotransplantation [0.03%]
用于异种移植的八个基因（GGTA1，CMAH，β4GalNT2，hCD46，hCD55，hCD59，hTBM和hCD39）编辑的供体猪的生产及功能验证
Jiaoxiang Wang,Kaixiang Xu,Tao Liu et al.
Jiaoxiang Wang et al.
Gene-edited (GE) pig-to-human xenotransplantation continues to make breakthroughs, but which kind of gene combination is suitable for organ-specific transplantation remains unclear. In this study, we utilised CRISPR/Cas9 gene editing techno...