Assessment of clinical pharmacology and competence during medicine clerkships [0.03%]
临床药理学评估及医学实习期胜任力评估
Nicole C Cheung,Kelly M Quesnelle,Hsinling Sonya Hung et al.
Nicole C Cheung et al.
Safe and effective prescribing is a competency recognized in frameworks created by various countries for medical students entering clinical practice. Clinical pharmacology education, when aligned with competency-based medical education (CBM...
Methodological considerations on paracetamol pharmacokinetics in spinal muscular atrophy: A response to Zhao et al [0.03%]
关于脊髓肌肉萎缩症患者中对乙酰氨基酚药代动力学的研究方法思考——致赵等人的一封信
Elvira Meni Maria Gkrinia,Iva Kristić,Andrej Belančić et al.
Elvira Meni Maria Gkrinia et al.
Availability, use, efficacy and safety of bevacizumab in European hereditary haemorrhagic telangiectasia centres [0.03%]
欧洲遗传性出血性毛细血管扩张症中心的贝伐单抗的可及性、使用率、有效性和安全性
Pernille D Haahr,Anette D Kjeldsen,Annette D Fialla et al.
Pernille D Haahr et al.
Introduction: Bevacizumab, a vascular endothelial growth factor inhibitor, is used off-label for treatment of severe anaemia related to epistaxis, gastrointestinal bleeding and/or severe hepatic arteriovenous malformation...
A scoping review of disease-modifying antirheumatic drug nonadherence in rheumatoid arthritis: Measurement, prevalence and implications for clinical practice [0.03%]
改善抗风湿药治疗不规律的类风湿性关节炎的研究概述：评估、统计和临床实践的意义
Lauren Fraser,Nagham Ailabouni,Lisa Kalisch Ellett et al.
Lauren Fraser et al.
Aims: Adherence to disease-modifying antirheumatic drugs (DMARDs) has been associated with improved treatment outcomes, but how adherence is reported ranges between studies. We therefore aimed to determine how nonadherenc...
Exploring Definity-related adverse reaction: A real-world pharmacovigilance study via FAERS database analysis [0.03%]
基于FAERS数据库的Definity用药风险探索性研究
Wenrong Lin,Yuhao Lin,Siqi Xu et al.
Wenrong Lin et al.
Aims: Definity, an ultrasound contrast agent (UCA), is widely utilized in echocardiography. Real-world studies on the safety of Definity in large populations are still lacking. This study aims to explore Definity-related ...
Comparative analysis of the characteristics and trends of adverse drug reaction reports from patients in Japan and the Japanese Adverse Drug Event Report database [0.03%]
日本患者和药品不良反应及事件报告数据库中药品不良反应的特点及趋势的比较分析
Masami Tsuchiya,Ryohkan Funakoshi,Koichi Masuyama et al.
Masami Tsuchiya et al.
Aims: Spontaneous reporting of adverse drug reactions (ADR) after a product has reached the market is essential for drug safety. This study analysed patient ADR reports and compared them with reports from the Japanese Adv...
Population pharmacokinetic/pharmacodynamic model of LY06006 in Chinese healthy subjects and postmenopausal osteoporotic women [0.03%]
LY06006在健康受试者和绝经后妇女中的群体药动/药效学模型
Yun Kuang,Ya-Xin Liu,Yan-Ni Teng et al.
Yun Kuang et al.
Aims: LY06006, a biosimilar of denosumab, is a recombinant fully human monoclonal antibody targeting the receptor activator of nuclear factor κB ligand. LY06006 has completed Phase I and Phase III clinical studies. The o...
Population pharmacokinetic modelling revealed large variability in oromucosal absorption of Δ9-tetrahydrocannabinol in older patients with poor appetite [0.03%]
人群药代动力学模型揭示了老年厌食症患者口服膜吸收Δ9-四氢大麻酚的变异性较大
Ida Klitzing Storgaard,Rikke Lundsgaard Nielsen,Morten Baltzer Houlind et al.
Ida Klitzing Storgaard et al.
Aim: Cannabis-based medicines are gaining interest and being explored for new therapeutic indications, many of which commonly affect older medical patients. As most previous studies of the population pharmacokinetics of c...
Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience [0.03%]
基于研究者的临床经验的早期临床试验中的不良免疫刺激的关键发现和建议
Juliette A van den Noort,Marella C E van Ruissen,Lisanne C A Smidt et al.
Juliette A van den Noort et al.
Problem setting: The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinic...