Identifying a therapeutic target for ganciclovir against cytomegalovirus in immunocompromised children [0.03%]
识别免疫缺陷儿童巨细胞病毒的抗病毒药物更昔洛韦的作用靶点
Wenyu Yang,Adam Irwin,Heather Weerdenburg et al.
Wenyu Yang et al.
Aims: Ganciclovir (GCV) is commonly used to treat cytomegalovirus (CMV) infections in immunocompromised children. Currently, the therapeutic target for effective treatment is unclear: Adult studies suggest that a serum ar...
Age-related differences in hydroxychloroquine-associated adverse events: A pharmacovigilance study based on the FDA Adverse Event Reporting System [0.03%]
基于美国食品和药物管理局不良事件报告系统中的羟氯喹相关不良反应的年龄差异——一项药物警戒研究
Guanghan Sun,Jingrong Yang,Lei Wan et al.
Guanghan Sun et al.
Aims: This real-world pharmacovigilance study utilizes FDA Adverse Event Reporting System (FAERS) data (2004-2024) to characterize age-related disparities in hydroxychloroquine (HCQ)-associated adverse events (AEs), addre...
Use of cimetidine to enhance systemic acyclovir concentrations in patients with ineffective suppressive therapy for recurring herpes simplex virus infections: A novel purpose for an old drug [0.03%]
西咪替丁增强系统性阿昔洛韦浓度用于抑制复发性单纯疱疹病毒感染：老药新用
Dominique G Stuijt,Victor M Cnossen,Amira F Y S M Osman et al.
Dominique G Stuijt et al.
Herpes simplex virus (HSV) may cause recurring oral or genital ulcers. We report a series of patients nonresponsive to suppressive valacyclovir therapy, explained by subtherapeutic acyclovir plasma levels. After a dose increase, or in some ...
Optimizing mycophenolic acid exposure for reduced relapse risk in paediatric nephrotic syndrome: An observational cohort study [0.03%]
优化麦考酚酸用药以减少儿童肾病综合征复发风险的一项观察性队列研究
Yiting Cai,Baojing Liu,Lizhi Chen et al.
Yiting Cai et al.
Aims: Mycophenolic acid (MPA) effectively reduces relapse in paediatric nephrotic syndrome (NS), yet its pharmacokinetic variability hinders optimal dosing. This study aimed to define risk reference values of MPA area und...
Pharmacokinetic profiles of sertraline in pregnancy as a predictor of postpartum depressive symptoms [0.03%]
孕期使用舍曲林的药动学特征可预测产后抑郁症状
Sílvia M Illamola,Zachary N Stowe,Marc L Kalin et al.
Sílvia M Illamola et al.
Aim: To characterize pharmacokinetic changes of sertraline and its metabolite during pregnancy and postpartum, and their relationship to maternal postpartum depressive symptoms. ...
Population pharmacokinetics of artemether-lumefantrine plus amodiaquine in patients with uncomplicated Plasmodium falciparum malaria [0.03%]
青蒿琥乙酯-卢莫司钠联合氨酚喹片治疗恶性疟的药代动力学研究
Junjie Ding,Richard M Hoglund,Rob W van der Pluijm et al.
Junjie Ding et al.
Aims: Resistance to the artemisinins and the artemisinin-based combination therapy (ACT) partner drugs has developed in Southeast Asia, and artemisinin resistance has also emerged in eastern Africa. Triple ACTs (triple ar...
Evaluation of the Medicines and Healthcare products Regulatory Agency's introduction of a risk-proportionate approach for clinical trials: An analysis of 4617 applications assessed between September 2023 and August 2024 [0.03%]
对药品和医疗产品监管局的风险相称临床试验方法的评估：分析2023年9月至2024年8月期间审评的4617份申请
Andrea Manfrin,Kingyin Lee,Crina Cacou et al.
Andrea Manfrin et al.
Aims: The Medicines and Healthcare products Regulatory Agency (MHRA) introduced a risk-proportionate approach to assess clinical trial applications for authorisation in August 2023. This study evaluates the impact of this...
Association between use of lubiprostone and headache: A systematic review and meta-analysis of randomized controlled trials [0.03%]
鲁比前列酮的使用与头痛之间的关联：随机对照试验的系统评价和meta分析
Satoru Mitsuboshi,Makoto Morizumi,Shungo Imai et al.
Satoru Mitsuboshi et al.
Aims: Lubiprostone and its active metabolite may activate prostaglandin receptors, raising concerns about an increased risk of headache. We performed a systematic review and meta-analysis to identify whether lubiprostone ...
Association between use of lubiprostone and headache: A systematic review and meta-analysis of randomized controlled trials [0.03%]
鲁比前列酮的使用与头痛之间的关系：随机对照试验的系统评价和meta分析
Satoru Mitsuboshi,Makoto Morizumi,Shungo Imai et al.
Satoru Mitsuboshi et al.
Aims: Lubiprostone and its active metabolite may activate prostaglandin receptors, raising concerns about an increased risk of headache. We performed a systematic review and meta-analysis to identify whether lubiprostone ...
Ulrich Limper,Jens Jordan
Ulrich Limper
Spaceflight imposes unique environmental challenges, including weightlessness, increased radiation exposure and confinement, which can lead to unexpected health effects. One such example is neck-vein thrombosis, a condition rarely seen on E...