From technological iteration to clinical breakthrough: advances of CAR-T cell therapy in autoimmune diseases [0.03%]
从技术迭代到临床突破：嵌合抗原受体T细胞治疗自身免疫性疾病的研究进展
Bingxuan Yu,Jingkai Xu,Yong Cui
Bingxuan Yu
Background: Chimeric antigen receptor (CAR) -T cell therapy has emerged as a promising approach for treating severe autoimmune diseases (AIDs), offering distinct advantages over conventional immunosuppressive therapies. T...
CT-based variables of perirenal fat are risk factors for assessing pathological T-stage in patients with clear cell renal cell carcinoma [0.03%]
基于CT的肾周脂肪变量是评估透明细胞肾细胞癌患者病理T期的危险因素
Hao Guo,Linlin Meng,Lingcheng Zhu et al.
Hao Guo et al.
Background: Advances in the treatment of clear cell renal cell carcinoma (ccRCC) toward risk-based therapy intensity modulation have necessitated patient-specific assessments of preoperative T-stage. ...
JAK inhibitor tofacitinib alleviates secretory dysfunction and Th17/Treg imbalance in a Sjögren's disease murine model [0.03%]
JAK抑制剂托法替尼改善Sjögren综合征模型小鼠的分泌功能障碍和Th17/Treg失衡
Yanjun Lin,Yanjing Ou,Jingjing Su et al.
Yanjun Lin et al.
Objectives: To examine whether the JAK inhibitor tofacitinib alleviates secretory dysfunction and modulates Th17/Treg balance in a Sjögren's disease (SjD) murine model. ...
A review of preclinical research on mechanically gated ion channels as therapeutic targets in neuropathic pain [0.03%]
机械门控离子通道作为神经病理性疼痛治疗靶点的前临床研究进展综述
Yafei Xie,Xinxin Wang,Jiajun Ju et al.
Yafei Xie et al.
Background: Neuropathic pain (NP), resulting from damage or disease affecting the somatosensory nervous system, severely impairs patients' quality of life and constitutes a substantial global disease burden. Recent eviden...
Impact of national volume-based procurement on physicians' antimicrobial prescribing behaviours: an interrupted time series analysis of 1200 prescriptions in a tertiary hospital [0.03%]
基于国家采购量的抗菌药物使用行为变化：一项三甲医院1200张处方的中断时间序列分析研究
Zhenzhen Du,Jiapei Yao,Xinru Liu et al.
Zhenzhen Du et al.
Objective: This study aimed to investigate the impact of the National Volume-Based Procurement (NVBP) policy on antimicrobial use intensity, prescribing structure, and medical costs among inpatients in a tertiary hospital...
Comparison of opioid-free versus opioid-based total intravenous anaesthesia in elderly patients undergoing short-duration surgery: a randomized controlled trial [0.03%]
老年短小手术患者静脉麻醉中无阿片类药物与含阿片类药物方案的比较：一项随机对照试验
Shirong Wei,Sitong Zhou,Junwen Tu et al.
Shirong Wei et al.
Introduction: Older adults who undergo short-duration surgery are vulnerable to opioid-related complications. It is uncertain whether an opioid-free total intravenous anaesthesia (OFA) can reduce these events. We aimed to...
Randomized Controlled Trial
Annals of medicine. 2026 Dec;58(1):2600751. DOI:10.1080/07853890.2025.2600751 2026
Letter to the editor regarding: 'Diagnostic value of plasma cell-free DNA metagenomic next-generation sequencing in patients with suspected infections and exploration of clinical scenarios - a retrospective study from a single center' [0.03%]
关于文章“疑似感染患者血浆游离DNA宏基因组测序的诊断价值及临床场景探索——单中心回顾性研究”的来信
Jingrong Qian,Jun Fang
Jingrong Qian
Nomogram for predicting in-stent stenosis after pipeline embolization device treatment in patients with unruptured intracranial aneurysm: a multicenter model development and validation study [0.03%]
未破裂颅内动脉瘤患者Pipeline血流导向装置治疗后内支架狭窄预测列线图的多中心模型构建及验证研究
Linggen Dong,Dachao Wei,Zizheng Wang et al.
Linggen Dong et al.
Background: Some intracranial aneurysms (IAs) still develop in-stent stenosis (ISS) even after successful pipeline embolization device (PED) implantation. ISS increases the risk of retreatment and ischemic complications, ...
Multicenter Study
Annals of medicine. 2026 Dec;58(1):2624994. DOI:10.1080/07853890.2026.2624994 2026
Marianna Minnetti,Eleonora Poggiogalle,Francesco Frigerio et al.
Marianna Minnetti et al.
Background: Sarcopenic obesity (SO) is a multifactorial condition characterized by the coexistence of excess adiposity and reduced skeletal muscle mass and function. Its development reflects a complex interaction of metab...