Targeted activation of PPARG or AKT1 alleviates liver injury in mice with type 2 diabetes and sepsis by modulating inflammatory and metabolic pathways [0.03%]
靶向激活PPARG或AKT1通过调节炎症和代谢途径缓解2型糖尿病合并脓毒症小鼠的肝损伤
Jie Ma,Xin Qi,Wendi Li et al.
Jie Ma et al.
Background: The simultaneous presence of sepsis and type 2 diabetic mellitus (T2DM) has a synergistic effect on hepatic damage. Although the activation of peroxisome proliferator-activate receptor gamma (PPARG) and AKT se...
David J Cangemi,Adam P Laitman,Orit Faiman et al.
David J Cangemi et al.
Introduction: Constipation and bloating are common bothersome gastrointestinal (GI) symptoms that frequently occur concurrently. It is important to recognize the underlying condition(s) and tailor therapeutic intervention...
Comparative analysis of natural versus ovarian stimulation cycles in intrauterine insemination by diverse infertility indications [0.03%]
不同不孕因素宫腔内人工授精新鲜周期中自然周期与微刺激方案的对比分析
Jia Fan,Luyi Li,Haiyan Xu et al.
Jia Fan et al.
Objective: To describe clinical intrauterine insemination (IUI) outcomes among infertile patients with different infertility indications, and further compare reproductive outcomes between natural cycle (NC) and ovarian st...
Comparative Study
Annals of medicine. 2026 Dec;58(1):2688370. DOI:10.1080/07853890.2026.2688370 2026
Wen Chen,Wencheng Zhou,Songjun Liu
Wen Chen
Background: The concept of ferroptosis debuted as a newly defined programmed cell death in 2012. Among programmed cell death mechanisms, ferroptosis stands out as being fundamentally dependent on iron. At the heart of thi...
Multi-trajectories of serum uric acid/high density lipoprotein cholesterol ratio and fasting plasma glucose in chronic kidney disease [0.03%]
慢性肾脏病患者血清尿酸/高密度脂蛋白胆固醇比值及空腹血糖的多轨迹变化分布及其与全因死亡率的关系
Mingxuan Xie,Zhenghong Luo,Huixian Xiong et al.
Mingxuan Xie et al.
Background: This study aimed to investigate the associations of longitudinal trajectories of the serum uric acid to high-density lipoprotein cholesterol ratio (UHR) and fasting plasma glucose (FPG) with chronic kidney dis...
Assessing nutritional risk and its association with mortality in ICU patients using the modified NUTRIC score: evidence from a tertiary care hospital [0.03%]
改良型NUTRIC评分在重症监护病房患者营养风险评估及其与病死率关联中的应用研究
Burhan Ahmad,Iqra Akhtar,Muhammad Taimur et al.
Burhan Ahmad et al.
Background: The objective of this study was to assess nutritional risk in ICU patients using the modified Nutritional Risk in Critically ill (mNUTRIC) score and to evaluate its association with in-hospital mortality. ...
Comparing the efficacy and safety of unilateral versus bilateral spinal anesthesia: a meta-analysis and systematic review [0.03%]
单侧与双侧脊麻效果和安全性的比较：一项meta分析和系统综述
Ji-Xiang Wan,Si-Si Zeng,Jia-Man Li et al.
Ji-Xiang Wan et al.
Background: Unilateral spinal anesthesia has gained increasing attention in recent years. Emerging evidence suggests that it provides comparable analgesia to conventional bilateral spinal anesthesia while reducing adverse...
Unveiling the cognitive fog in lung cancer patients: non-invasive exploration of blood-brain barrier disruption and brain structural changes [0.03%]
揭开肺癌患者认知障碍的面纱：非侵入性探索血脑屏障破坏和脑结构变化
Da-Fu Zhang,Huan Ma,Zhi-Ping Zhang et al.
Da-Fu Zhang et al.
Background: This study investigates the correlation between blood-brain barrier (BBB) damage and cognitive impairment in patients suffering from untreated lung cancer. The study aims to understand the impact of BBB permea...
Association of ERBB4 and SHBG gene polymorphisms with polycystic ovarian syndrome in South Indian women: a case-control genetic analysis [0.03%]
ERBB4和SHBG基因多态性与南印度妇女多囊卵巢综合征的相关性：一项病例对照基因组学分析
Sheena Mariam Thomas,Nithya Ajay,Vijayalakshmi Kandasamy et al.
Sheena Mariam Thomas et al.
Introduction: Polycystic ovary syndrome (PCOS) is a multifactorial endocrinological disorder with a substantial genetic component. However, the role of genes involved in follicular development and androgen regulation rema...
Combined effects of maternal periconceptional environmental exposures and infant cardiac transcription factor polymorphisms on congenital heart disease risk [0.03%]
母亲围受孕期环境暴露与婴儿心脏转录因子多态性对先天性心脏病的联合影响
Jianhui Wei,Peng Huang,Letao Chen et al.
Jianhui Wei et al.
Background: Congenital heart disease (CHD) is a leading cause of neonatal morbidity and mortality, with a complex aetiology involving genetic and environmental factors. Cardiac transcription factors, such as NKX2.5, GATA4...