A system-level metastable model of cancer evolution: integrating replication stress, cell cycle deregulation and chromosomal instability [0.03%]
癌症进化系统水平的亚稳定模型：整合复制压力、细胞周期失调和染色体不稳定
Dongjing Ma,Jinbin Wang,Yicong Chen et al.
Dongjing Ma et al.
Introduction: Cancer cell proliferation occurs within the context of persistent genomic instability. In this review, we propose the RS-CCD-CIN axis as a systems-level framework in which replication stress (RS), cell cycle...
Pre-ablation stimulated thyroglobulin to TSH ratio as a strong predictor of non-generally satisfactory response to initial radioiodine therapy in papillary thyroid carcinoma patients undergoing lateral neck dissection [0.03%]
术前刺激甲状腺球蛋白与促甲状腺激素比值可预测分化型甲状腺癌患者初始131I治疗效果不佳
Weijian Li,Pengpeng Chang,Mingque Feng et al.
Weijian Li et al.
Background: The initial response to radioiodine (1³1I) therapy is a critical determinant of prognosis in papillary thyroid carcinoma (PTC) patients undergoing therapeutic lateral neck dissection (LND). This study aimed t...
Neuroimmune circuits in respiratory pathophysiology: decoding molecular crosstalk for precision therapeutic targeting [0.03%]
呼吸系统病理生理学中的神经免疫回路：解码分子交叉对话以实现精准治疗靶向定位
Qian Chen,Nan Jia,Junling Liu et al.
Qian Chen et al.
Background: The lung is a uniquely innervated barrier organ with dynamic neuroimmune interactions that critically regulate respiratory homeostasis. Despite the well-characterized gut-brain axis, pulmonary neuroimmune cros...
Clinicopathological characteristics and therapeutic outcomes in patients with non-small cell lung cancer harboring SMARCA4 mutations [0.03%]
SMARCA4突变非小细胞肺癌的临床病理特征和治疗结局分析
Yan Liu,Hui Li,Xiang Li et al.
Yan Liu et al.
Objective: To investigate the clinical characteristics and impact of SMARCA4 mutations in patients with non-small cell lung cancer (NSCLC). Methods: ...
Application of artificial intelligence in head and neck squamous cell carcinoma [0.03%]
人工智能在头颈部鳞癌中的应用
Peipei Wang,Jiaxin Tian,Guowan Zheng et al.
Peipei Wang et al.
Background: Head and neck squamous cell carcinoma (HNSCC) emerges from the mucosal linings of the paranasal sinuses, nasal cavities, oral cavity, nasopharynx, oropharynx, hypopharynx and larynx. Despite significant advances in understanding...
Advances in pharmacological interventions for hepatic fibrosis: from pathogenic mechanisms to novel therapeutic targets [0.03%]
肝纤维化治疗的药物干预研究进展：从发病机制到新药靶点
Weiqin Zhang,Ting Shao,Caiyan Wang et al.
Weiqin Zhang et al.
Hepatic fibrosis (HF) is a pahological consequence of dysregulated wound healing, characterized by excessive deposition of extracellular matrix (ECM) that disrupts liver architecture and function.It is driven by diverse etiologies, includin...
Clinical outcomes of metastatic non-clear cell renal cell carcinoma: a real-world single-centre experience [0.03%]
转移性非透明细胞肾癌的临床结局：单一中心的真实世界经验
Jie Wu,Chuan-Zhen Cao,Hong-Lei Cui et al.
Jie Wu et al.
Purpose: In the current study, we aimed to characterize the clinicopathological features of metastatic non-clear cell renal cell carcinoma (nccRCC) using retrospective data from our centre and to assess the clinical outco...