Sea urchin nanostructured nickel cobaltite modified carbon cloth integrated wearable patches for the on-site detection of the immunosuppressant drug mycophenolate mofetil [0.03%]
用于现场检测免疫抑制剂药物霉酚酸酯的海胆纳米结构镍钴ite修饰碳布集成可穿戴补丁
K Niyas,Bartholomew Richard,Menon Ankitha et al.
K Niyas et al.
Mycophenolate mofetil (MpM) is a medication used to prevent the rejection of transplanted organs, particularly in kidney, heart, and liver transplant surgeries. It is extremely important to be conscious that MpM can raise the risk of severe...
Eva Kočišová,Alžbeta Kuižová,Marek Procházka
Eva Kočišová
The droplet deposition methods in Raman spectroscopy have received considerable attention in the field of analytical sensing focusing on effective pre-concentration of the studied analyte (coffee-ring effect or small spots). This review cov...
A bimodal time-gated luminescence-magnetic resonance imaging nanoprobe based on a europium(III) complex anchored on BSA-coated MnO2 nanosheets for highly selective detection of H2O2 [0.03%]
一种基于Eu(Ⅲ)配合物的包覆BSA的MnO₂纳米片的双模时门发光-磁共振成像纳米探针用于H₂O₂的选择性检测
Bo Song,Ziyao Wang,Huinan Yan et al.
Bo Song et al.
A novel nanocomposite, [Eu(BTD)3(DPBT)]-BSA@MnO2, is reported to serve as an effective nanoprobe for bimodal time-gated luminescence (TGL) and magnetic resonance (MR) imaging of H2O2in vitro and in vivo. The nanoprobe was fabricated by immo...
FARPA-based tube array coupled with quick DNA extraction enables ultra-fast bedside detection of antibiotic-resistant pathogens [0.03%]
基于FARPA的管阵列结合快速DNA提取可在床边超快检测抗生素耐药性病原体
Jinling Huang,Huijie Yue,Wei Wei et al.
Jinling Huang et al.
Rapid and accurate detection of pathogens and antimicrobial-resistant (AMR) genes of the pathogens are crucial for the clinical diagnosis and effective treatment of infectious diseases. However, the time-consuming steps of conventional cult...
Online monitoring of epithelial barrier kinetics and cell detachment during cisplatin-induced toxicity of renal proximal tubule cells [0.03%]
顺铂诱导的肾近端小管上皮细胞毒性作用中的上皮屏障动力学及细胞脱落的在线监测研究
Yuji Takata,Ramin Banan Sadeghian,Kazuya Fujimoto et al.
Yuji Takata et al.
Real-time and non-invasive assessment of tissue health is crucial for maximizing the potential of microphysiological systems (MPS) for drug-induced nephrotoxicity screening. Although impedance has been widely considered as a measure of the ...
A SARS-CoV-2 Mpro fluorescent sensor for exploring pharmacodynamic substances from traditional Chinese medicine [0.03%]
一种针对SARS-CoV-2 Mpro的荧光传感器用于探索中药中的药效物质
Lei Han,Bing Wang,Kunhui Sun et al.
Lei Han et al.
The main protease of SARS-CoV-2 (SARS-CoV-2 Mpro) plays a critical role in the replication and life cycle of the virus. Currently, how to screen SARS-CoV-2 Mpro inhibitors from complex traditional Chinese medicine (TCM) is the bottleneck fo...
Acoustic detection of a mutation-specific Ligase Chain Reaction based on liposome amplification [0.03%]
基于脂质体扩增的突变特异性连接酶链反应的声学检测方法研究
Nikoletta Naoumi,Monica Araya-Farias,Maria Megariti et al.
Nikoletta Naoumi et al.
Single nucleotide variants (SNVs) play a crucial role in understanding genetic diseases, cancer development, and personalized medicine. However, existing ligase-based amplification and detection techniques, such as Rolling Circle Amplificat...
High-throughput direct screening of restriction endonuclease using a microfluidic fluorescence-activated drop sorter based on the SOS response in Escherichia coli [0.03%]
基于SOS响应的微流体荧光激活液滴分选器在限制性内切酶高通量直接筛选中的应用
Yizhe Zhang,Jeremy J Agresti,Yu Zheng et al.
Yizhe Zhang et al.
A restriction endonuclease (RE) is an enzyme that can recognize a specific DNA sequence and cleave that DNA into fragments with double-stranded breaks. This sequence-specific cleaving ability and its ease of use have made REs commonly used ...
A binding-triggered hybridization chain reaction cascade multi-site activated CRISPR/Cas12a signal amplification strategy for sensitive detection of α-synuclein [0.03%]
一种用于灵敏检测α-突触核蛋白的链反应级联多点激活CRISPR / Cas12a信号放大策略
Zhenzhuo Wan,Jiahao Lu,Lu Lu et al.
Zhenzhuo Wan et al.
Alpha-synuclein (α-syn) is closely related to the pathological process of Parkinson's disease (PD). Sensitive detection of α-syn is important for the early diagnosis and disease progression monitoring of PD. Herein, we report a binding-tr...
Electroactive polymer tag modified nanosensors for enhanced intracellular ATP detection [0.03%]
一种改良纳米传感器，用于增强细胞内ATP检测的电活性聚合物标签
Yi-Ran Kang,Yu-Ting Jiao,Chen-Fei Zhao et al.
Yi-Ran Kang et al.
ATP plays a crucial role in cell energy supply, so the quantification of intracellular ATP levels is particularly important for understanding many physio-pathological processes. The intracellular quantification of this non-electroactive mol...