Negative selection assisted isolation of a highly selective DNA aptamer for the detection of 17α-ethinylestradiol [0.03%]
负向选择辅助法捕获高选择性识别雌二醇的DNA适配体用于雌二醇的检测
Nathania Lui,Qiushi Liu,Juewen Liu
Nathania Lui
Estrogenic compounds, including both natural estrogens such as estrone (E1) and 17β-estradiol (E2) and synthetic 17α-ethinylestradiol (EE2), are widely recognized for their endocrine-disrupting effects in the environment. EE2 is a key ing...
Nucleic acid aptamer-functionalized magnetic MIL-53(Al)-NH2 for highly selective magnetic dispersion solid-phase extraction of chloramphenicol [0.03%]
氯霉素高选择性磁分散固相萃取法研究——利用核糖核酸适配子功能化的MIL-53(Al)-NH₂磁材料
Liangliang Peng,Yao Yao,Meiqi Li et al.
Liangliang Peng et al.
Chloramphenicol (CAP), a broad-spectrum antibiotic banned in food animals due to its toxic effects (e.g., myelosuppression), requires sensitive analytical methods for the detection and monitoring of its residues in food. Herein, an aptamer-...
Harnessing a UiO-66-NH2/LaFeO3 nanocomposite for the electrochemical sensing of prednisone [0.03%]
利用UiO-66-NH2 / LaFeO3 纳米复合材料电化学检测泼尼松
Adrian Ebenezer Paul,Nandhini Panchatcharam,Jerry J Wu et al.
Adrian Ebenezer Paul et al.
Prednisone is a synthetic corticosteroid that mimics cortisol by regulating blood pressure, the immune system, and inflammatory processes. Its widespread presence in biological systems underscores its involvement in various physiological pr...
Multimodal AFM-IR nanospectroscopy and non-linear optical microscopy for detecting collagen matrix alterations [0.03%]
用于检测胶原矩阵变化的多模态AFM-IR纳米光谱法和非线性光学显微镜技术
Jérémie Mathurin,Gaël Latour,Gervaise Mosser et al.
Jérémie Mathurin et al.
Correlative photothermal infrared nanospectroscopy (AFM-IR) and non linear optical microscopy analyses reveal that the emergence of a 1730 cm-1 IR band in collagen arises from local, thermally induced esterification. This band serves as a m...
Juniper-based Cu@activated carbon functionalized with ethylenediamine: a green platform for non-enzymatic detection of dopamine [0.03%]
以乙烯胺功能化活性炭载铜纳米颗粒的绿色非酶型多巴胺检测平台
Afef Dhaffouli,Pedro A Salazar-Carballo,Soledad Carinelli et al.
Afef Dhaffouli et al.
We report a green and scalable strategy to engineer a next-generation dopamine (DA) sensor using copper-based nanoparticles (Cu-based NPs) on activated carbon derived from juniper seeds and functionalized with ethylenediamine (Cu@AC-CONH-CH...
Pinched-flow fractionation-based extracellular vesicle isolation by ExoFAST and its analytical benchmarking with commercial technologies [0.03%]
基于ExoFAST的挤压流动分离衍生的外泌体分离及其与商业技术的分析基准测定
Chaithanya Chelakkot,Yanymee N Guillen-Quispe,Jongjin Jo et al.
Chaithanya Chelakkot et al.
The growing interest in liquid biopsy biomarkers for non-invasive diagnostic approaches has spot-lighted extracellular vesicles (EVs), particularly exosomes, as promising candidates. However, robust and reproducible isolation of EVs with we...
Study on low temperature enrichment-headspace sampling-proton transfer reaction-mass spectrometry (LTE-HS-PTR-MS) for highly sensitive analysis of trace exhaled VOCs [0.03%]
基于低温富集的呼出挥发性有机物分析方法研究
Jie Jin,Wei Xu,Ning Zhang et al.
Jie Jin et al.
To address the challenge of detecting low concentrations of trace volatile organic compounds (VOCs) in exhalation with high humidity, this study developed a highly sensitive detection technique named low temperature enrichment-headspace sam...
Self-protected circular DNAzyme for integrated enrichment and quantification of small extracellular vesicles [0.03%]
自我保护的环状DNA酶，用于小型细胞外囊泡的集成富集和定量检测
Qianqian Wu,Yican Li,Ruyan Niu et al.
Qianqian Wu et al.
Small extracellular vesicles (sEVs) hold immense potential for liquid biopsy given the wealth of biological information they carry. Currently, the clinical application of these methods is limited due to their low abundance and the complexit...
Fluorescent aptasensor for enrofloxacin detection based on APE1-assisted amplification and CsPbBr3@MSN nanocomposites [0.03%]
基于APE1辅助放大和CsPbBr3@MSN纳米复合材料的恩诺沙星荧光适配子传感器
Huanhuan He,Jing Feng,Luna Guo et al.
Huanhuan He et al.
In this work, a fluorescent aptasensor was constructed for enrofloxacin (ENR) detection by combining the polyvalent aptamer (PA) structure, apurinic/apyrimidinic endonuclease 1 (APE1)-mediated signal amplification and mesoporous silica-enca...
A highly sensitive Love-wave surface acoustic wave immunosensor for point-of-care detection of Cyfra21-1 in saliva [0.03%]
一种高灵敏度的Love表面声波免疫传感器用于检测唾液中的Cyfra21-1分子标志物
Xiaojing Zhang,Hongyang Guo,Li Sin Wong et al.
Xiaojing Zhang et al.
Decentralized biomarker testing is pivotal for cancer screening, risk evaluation, and longitudinal surveillance, yet most established assays remain laboratory-centric and are not suitable for point-of-care testing (POCT). Saliva has attract...