Synthesis of fluorene-indole/benzofuran bicyclic molecules through palladium-catalyzed carboheterofunctionalization of alkynes [0.03%]
Huirong Li,Wenyu Zhang,Shuwei Zhang et al.
Huirong Li et al.
A novel palladium-catalyzed carboheterofunctionalization of alkynes has been developed, providing an efficient strategy for the synthesis of fluorene-indole and fluorene-benzofuran biscycles in moderate to good yields. This protocol exhibit...
Recent advances in mechanistic insights and regulation strategies of cobalt-based catalysts for enhanced electrocatalytic hydrogen production [0.03%]
Abhishikta Chatterjee,Papri Mondal,Bibhutosh Adhikary et al.
Abhishikta Chatterjee et al.
This review examines recent progress in cobalt-based molecular catalysts for electrochemical water splitting as a sustainable route for green hydrogen (H2) production. H2 is highlighted as a clean energy carrier, with water splitting, compr...
Preactivation-free direct decarboxylative alkynylation of indoleacetic acids: access to alkynyl-functionalized indoles [0.03%]
Gui-Ting Song,Yuan Zhou,Xue-Ying Yang et al.
Gui-Ting Song et al.
Herein, we report, to the best of our knowledge, the first preactivation-free decarboxylative alkynylation of indoleacetic acids with terminal alkynes via transition-metal catalysis. This protocol operates under mild conditions, forges C(sp...
Rational engineering of a highly sensitive and specific tyrosinase probe for guiding melanoma surgical resection [0.03%]
Yifeng Jian,Yongnan Luo,Ke Li et al.
Yifeng Jian et al.
Herein, a novel tyrosinase probe (SCy-tyr) was developed to overcome the limitations of poor selectivity and low activation efficiency, providing a new tool for precise imaging and surgical resection of melanoma.
Hang Chen,Shihui Zang,Yifu Chen et al.
Hang Chen et al.
Emerging from liposomes, nanomedicines have been rapidly developed into powerful tools for the diagnosis, therapy, and prevention of diseases. After bypassing from physiological barriers, most nanoparticles are interrupted on the way to sub...
Supramolecular glass formation by arene-perfluoroarene pairing of three-dimensional macrocycles [0.03%]
Katsuto Onishi,Shunsuke Ohtani,Kenichi Kato et al.
Katsuto Onishi et al.
We report supramolecular glass formation by mixing two crystalline pillar[6]arenes bearing benzyl and pentafluorobenzyl substituents, even though neither compound exhibited a melting point. The glass formation was attributed to arene-perflu...
Hen Moshe Halamish,Roni Sverdlov Arzi,Alejandro Sosnik
Hen Moshe Halamish
This work develops and characterises a hierachichal oral drug delivery system based on the microencapsulation of drug-loaded amphiphilic nanogels within a mucoadhesive alginate/chitosan shell. Results show a more controlled release and a st...
Tomohiro Seki,Rintaro Ishikawa,Kaisei Yamamoto et al.
Tomohiro Seki et al.
Crystals of an α-isocyanostilbene derivative show temperature-selective photomechanical behavior. At ambient temperature, they exhibit bending without splitting or moving under UV light, while below -50 °C, they show splitting upon photoi...
Cross-coupling of aryl aldehydes and benzyl chlorides enabled by dual N-heterocyclic carbene/cobalt catalysis [0.03%]
Hassan Jomaa,David Martin,Eder Tomás-Mendivil
Hassan Jomaa
We have developed a dual N-heterocyclic carbene/cobalt-salen catalytic system for the cross-coupling between aryl aldehydes and benzyl chlorides via direct C-H activation of aldehydes. The catalysts employed are readily accessible and the t...
Chemically modified nucleic acid nanodevices: molecular engineering for drug delivery, theranostics, biosensing and diagnostics [0.03%]
Caini Wang,Shuyao Yang,Ting Wang et al.
Caini Wang et al.
The intrinsic programmability of nucleic acids has positioned them as versatile molecular building blocks for constructing nanodevices with significant diagnostic and therapeutic potential. However, the clinical translation of these constru...