Multi-institutional experimental validation of online adaptive proton therapy workflows [0.03%]
多机构联合验证在线自适应质子治疗流程
Mislav Bobić,Evangelia Choulilitsa,Hoyeon Lee et al.
Mislav Bobić et al.
Objective.To experimentally validate two online adaptive proton therapy (APT) workflows using Gafchromic EBT3 films and optically stimulated luminescent dosimeters (OSLDs) in an anthropomorphic head-and-neck phantom.Approach.A three-field p...
Multicenter Study
Physics in medicine and biology. 2024 Aug 6;69(16). DOI:10.1088/1361-6560/ad6527 2024
Robust optimization strategies for contour uncertainties in online adaptive radiation therapy [0.03%]
自适应放射治疗轮廓不确定度的鲁棒优化策略研究
A Smolders,I Bengtsson,A Forsgren et al.
A Smolders et al.
Objective.Online adaptive radiation therapy requires fast and automated contouring of daily scans for treatment plan re-optimization. However, automated contouring is imperfect and introduces contour uncertainties. This work aims at develop...
Multi-modal fusion and feature enhancement U-Net coupling with stem cell niches proximity estimation for voxel-wise GBM recurrence prediction [0.03%]
基于多模态融合与特征增强的U-Net结合神经干细胞龛位置估计的胶质母细胞瘤复发预测方法
Changzhe Jiao,Yi Lao,Wenwen Zhang et al.
Changzhe Jiao et al.
Objective.We aim to develop a Multi-modal Fusion and Feature Enhancement U-Net (MFFE U-Net) coupling with stem cell niche proximity estimation to improve voxel-wise Glioblastoma (GBM) recurrence prediction.Approach.57 patients with pre- and...
Dosimetry of microbeam radiotherapy by flexible hydrogenated amorphous silicon detectors [0.03%]
采用柔性非晶硅氢化物探测器对纳米束放疗进行剂量学研究
Matthew James Large,Keida Kanxheri,Jessie Posar et al.
Matthew James Large et al.
Objective.Detectors that can provide accurate dosimetry for microbeam radiation therapy (MRT) must possess intrinsic radiation hardness, a high dynamic range, and a micron-scale spatial resolution. In this work we characterize hydrogenated ...
Resolution limits for radiation-induced acoustic imaging for in vivo radiation dosimetry [0.03%]
辐射诱发声学成像的分辨率限制，用于体内辐射剂量学
Prabodh Kumar Pandey,Kristina Bjegovic,Gilberto Gonzalez et al.
Prabodh Kumar Pandey et al.
Objective.Radiation-induced acoustic (RA) computed tomographic (RACT) imaging is being thoroughly explored for radiation dosimetry. It is essential to understand how key machine parameters like beam pulse, size, and energy deposition affect...
A deep-learning-based surrogate model for Monte-Carlo simulations of the linear energy transfer in primary brain tumor patients treated with proton-beam radiotherapy [0.03%]
基于深度学习的代理模型在原发性脑肿瘤患者质子束放射治疗线性能量传递蒙特卡洛模拟中的应用研究
Sebastian Starke,Aaron Kieslich,Martina Palkowitsch et al.
Sebastian Starke et al.
Objective.This study explores the use of neural networks (NNs) as surrogate models for Monte-Carlo (MC) simulations in predicting the dose-averaged linear energy transfer (LETd) of protons in proton-beam therapy based on the planned dose di...
A framework for in-field and out-of-field patient specific secondary cancer risk estimates from treatment plans using the TOPAS Monte Carlo system [0.03%]
利用TOPAS蒙特卡罗系统进行基于放疗计划的原发肿瘤患者位置内外次级癌风险评估框架研究
Isaac Meyer,Nils Peters,Giulia Tamborino et al.
Isaac Meyer et al.
Objective. To allow the estimation of secondary cancer risks from radiation therapy treatment plans in a comprehensive and user-friendly Monte Carlo (MC) framework.Method. Patient planning computed tomography scans were extended superior-in...
Holistic evaluation of a machine learning-based timing calibration for PET detectors under varying data sparsity [0.03%]
基于机器学习的PET检测器定时校准的全面评估：在数据稀疏性变化下的表现
Stephan Naunheim,Florian Mueller,Vanessa Nadig et al.
Stephan Naunheim et al.
Objective.Modern PET scanners offer precise TOF information, improving the SNR of the reconstructed images. Timing calibrations are performed to reduce the worsening effects of the system components and provide valuable TOF information. Tra...
Collection efficiencies of cylindrical and plane parallel ionization chambers: analytical and numerical results and implications for experimentally determined correction factors [0.03%]
圆柱形和平行板电离室的收集效率：解析和数值结果及其对实验测定修正因子的影响
John D Fenwick,Sudhir Kumar,Juan Pardo-Montero
John D Fenwick
Objectives.To derive a collection efficiency formula,fGauss, for cylindrical ionization chambers in pulsed radiation beams from a volume recombination model of Boaget al(1996Phys. Med. Biol.41885-97) including free electrons. To validatefGa...
Investigations on the beam quality correction factor for ionization chambers in high-energy brachytherapy dosimetry [0.03%]
高能后装治疗剂量学中电离室的束流质量校正因子研究
T Failing,F W Hensley,B Keil et al.
T Failing et al.
Objective. To enhance the investigations on MC calculated beam quality correction factors of thimble ionization chambers from high-energy brachytherapy sources and to develop reliable reference conditions in source and detector setups in wa...