Docking and molecular dynamic simulations of Mithramycin-A and Tolfenamic acid against Sp1 and survivin [0.03%]
灰黄霉素和托芬替康对Sp1和survivin的对接及分子动力学模拟研究
Christoffer Briggs Lambring,Hope Fiadjoe,Santosh Kumar Behera et al.
Christoffer Briggs Lambring et al.
Therapeutic targeting of Sp1 transcription factor and survivin, are studied in various cancers due to their consistent overexpression. These markers result in poorer cancer prognoses and their downregulation has been investigated as an effe...
Diandra Martinez-Cano,Rashmi Ravichandran,Huong Le et al.
Diandra Martinez-Cano et al.
One of the outcomes from the global COVID-19 pandemic caused by SARS-CoV-2 has been an acceleration of development timelines to provide treatments in a timely manner. For example, it has recently been demonstrated that the development of mo...
Baculovirus-expressed self-assembling SARS-CoV-2 nanoparticle vaccines targeting the S protein induce protective immunity in mice [0.03%]
表达SARS-CoV-2刺突蛋白的杆状病毒纳米颗粒疫苗诱导小鼠产生保护性免疫反应
Xingjian Liu,Haozhi Song,Jianmin Jiang et al.
Xingjian Liu et al.
Spike (S) protein, a homotrimeric glycoprotein, is the most important antigen target for SARS-CoV-2 vaccines. A complete simulation of the advanced structure of this homotrimer during subunit vaccine development is the most likely method to...
Convalescent plasma (hyperimmune immunoglobulin) for COVID-19 management: An update [0.03%]
COVID-19管理中关于恢复期血浆（高免免疫球蛋白）应用的最新进展更新报告
Vivek P Chavda,Rajashri Bezbaruah,Sheetal Dolia et al.
Vivek P Chavda et al.
The pandemic COVID-19 has spread widely throughout the globe and has been responsible for millions of deaths worldwide. Recently, it has been identified that there is no specific and 100% effective treatment available to manage the infectio...
Structural and biochemical characterization of Leptospira interrogans Lsa45 reveals a penicillin-binding protein with esterase activity [0.03%]
莱姆病原体Leptospira interrogans 的Lsa45的结构和生化特性分析揭示了一种具有酯酶活性的青霉素结合蛋白
Jademilson C Santos,Sumit Handa,Luis G V Fernandes et al.
Jademilson C Santos et al.
Leptospirosis is a bacterial disease that affects humans and animals and is caused by Leptospira. The recommended treatment for leptospirosis is antibiotic therapy, which should be given early in the course of the disease. Despite the use o...
Lessons learned from COVID-19 pandemic: Vaccine platform is a key player [0.03%]
从COVID-19疫情中汲取的教训：疫苗平台是关键参与者
Samira Hossaini Alhashemi,Fatemeh Ahmadi,Ali Dehshahri
Samira Hossaini Alhashemi
The SARS-CoV-2 outbreak and emergence of COVID-19 resulted in the development of different vaccines based on various platforms to combat the disease. While the conventional platforms of inactivated/live attenuated, subunit proteins and viru...
The inhibitory effect of curcumin loaded poly (vinyl caprolactam) nanohydrogel on insulin fibrillation [0.03%]
负载姜黄素的聚(乙烯基己内酰胺)纳米水凝胶对胰岛素纤维化的抑制作用
Marzieh Bahmani,Mohsen Akbarian,Lobat Tayebi et al.
Marzieh Bahmani et al.
Amyloidosis refers to a group of diseases caused by the deposition of abnormal proteins in tissues. Herein, curcumin was loaded in a nanohydrogel made of poly (vinylcaprolactam) to improve its solubility and was employed to exert an inhibit...
Novel electrochemical biosensor key significance of smart intelligence (IoMT & IoHT) of COVID-19 virus control management [0.03%]
用于COVID-19病毒管控的智能物联网(IoMT&IoHT)新型电化学生物传感器的关键意义
Amogha G Paladhi,M Manohar,Kaushik Pal et al.
Amogha G Paladhi et al.
Recent outbreak of COVID-19 pandemic has led to the different possibilities of the development of treatment against corona virus. To know the phylogenicity of SARS-CoV, various studies have been conducted with the outcome of the results sho...
Charge transport properties of SARS-CoV-2 Delta variant (B.1.617.2) [0.03%]
SARS-CoV-2Delta变体(B.1.617.2)的电荷传输性质
Lijun He,Zhiyang Xie,Xing Long et al.
Lijun He et al.
The B.1.617.2 (Delta) variant of concern is causing a new wave of infections in many countries. In order to better understand the changes of the SARS-CoV-2 mutation at the genetic level, we selected six mutations in the S region of the Delt...
Chromohalobacter salixigens Uronate Dehydrogenase: Directed Evolution for Improved Thermal Stability and Mutant CsUDH-inc X-ray Crystal Structure [0.03%]
盐化绿硫细菌葡萄糖酸脱氢酶的定向进化及CsUDH-inc突变体的X-射线晶体结构分析
Kurt Wagschal,Victor J Chan,Jose H Pereira et al.
Kurt Wagschal et al.
Chromohalobacter salixigens contains a uronate dehydrogenase termed CsUDH that can convert uronic acids to their corresponding C1,C6-dicarboxy aldaric acids, an important enzyme reaction applicable for biotechnological use of sugar acids. T...