Transcapillary forces of the subcutaneous tissue in patients treated with interleukin-2 and alpha-interferon: no capillary protein leak syndrome? [0.03%]
接受白细胞介素-2和α干扰素治疗的病人皮下组织的毛细血管跨膜压：无蛋白质渗漏综合征？
K A Semb,S Aamdal,S D Fosså et al.
K A Semb et al.
The purpose of this study was to evaluate whether treatment with interleukin-2 (IL-2) and alpha-interferon (IFN-alpha-2a) causes protein leakage from plasma to the interstitium, leading to the so called 'capillary leak syndrome'. This syndr...
Clinical Trial
Journal of experimental therapeutics & oncology. 1996 May;1(3):155-61. DOI: 1996
Tumoricidal potential of human macrophages grown in vitro from blood monocytes [0.03%]
人外周血单核细胞体外诱导巨噬细胞的溶瘤效应研究
M Lopez,V Bony,C Martinache et al.
M Lopez et al.
Adoptive transfer of activated autologous human macrophages obtained by in vitro differentiation of monocytes in culture has successfully undergone phase I clinical trials in patients with metastatic cancer. The efficacy of these autologous...
R H Matthews,N Ercal
R H Matthews
Mucositis has been a significant debilitating side effect to the treatment of head and neck cancer by irradiation. A change in prophylactic treatment policy was made in August 1991 such that a total of 59 patients was divided into two group...
Clinical Trial
Journal of experimental therapeutics & oncology. 1996 Mar;1(2):135-8. DOI: 1996
Immunization of mice with irradiated melanoma tumor cells transfected to secrete lymphokines and coupled with IL-2 or GM-CSF therapy [0.03%]
转染产生淋巴因子的黑色素瘤肿瘤细胞的照射免疫与IL-2或GM-CSF治疗联合使用的效果探讨(英文)
D P Shrayer,H Bogaars,V J Hearing et al.
D P Shrayer et al.
We compared the immunogenic activity of irradiated vaccines prepared from B16 F10 melanoma cells with one made from B16 F10 melanoma cells transfected with genes encoding murine IL-2 or GM-CSF. Vaccines were studied in the conditions of tre...
Comparative antitumor activities of halichondrins and vinblastine against human tumor xenografts [0.03%]
海萝生物碱和长春花生物碱抗肿瘤活性的比较研究
O Fodstad,K Breistøl,G R Pettit et al.
O Fodstad et al.
Halichondrin B and homohalichondrin B are novel tubulin-interacting agents isolated from marine sponges. The in vivo antitumor activities of these compounds were examined in human tumor models in immunodeficient mice and rats. In nude mice,...
Comparative Study
Journal of experimental therapeutics & oncology. 1996 Mar;1(2):119-25. DOI: 1996
MDL 201,307: a novel benzothiazepine modulator of multiple drug resistance [0.03%]
新型苯并噻氮卓类多药耐药调节剂MDL 201,307
R A Newman,D Fan,H R Munson et al.
R A Newman et al.
A series of novel benzothiazepine derivatives were evaluated for their relative potential to reverse multiple drug resistance (MDR) phenotype in vitro as well as for their relative cardiovascular activity and neurotoxicity. Compounds were e...
T H Corbett,F A Valeriote,L Demchik et al.
T H Corbett et al.
Cryptophycin-8 was prepared by the conversion of the epoxide group on cryptophycin-1 to a chlorohydrin. In the studies reported here, cryptophycin-8 was evaluated for preclinical activity against subcutaneous tumors of both mouse and human ...
Expression of cyclin E in human gastric adenomas and adenocarcinomas: correlation with proliferative activity and p53 status [0.03%]
人胃腺瘤和腺癌中细胞周期素E的表达及其与增殖活性和P53状态的相关性研究
W Yasui,Y Akama,H Kuniyasu et al.
W Yasui et al.
The expression of cyclin E in human gastric adenomas and adenocarcinomas was examined immunohistochemically to elucidate the role of cyclin E in stomach carcinogenesis. The expression of cyclin E was detected in 49% (90/182) of the adenomas...
Phase I trial of a 24-h continuous infusion of ifosfamide/mesna in acute lymphoblastic leukemia [0.03%]
急性淋巴细胞白血病患者使用异环磷酰胺/美司钠连续24小时静滴的I期临床试验
J C Otero,A Solidoro,L Casanova et al.
J C Otero et al.
Based on previous reports suggesting that an intravenous (i.v.) continuous infusion of alkylating agents produced a significant response rate in acute lymphoblastic leukemia (ALL), a phase I trial of ifosfamide/mesna (IFO/MES) was conducted...
E E DeCruz,T L Walker,C R Dass et al.
E E DeCruz et al.
A decade of advances in understanding of the molecular basis of sporadic and familial cancers has combined with developments in mammalian gene transfer technology to stimulate intensive research into the potential applications of somatic ge...