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Phase I trial of a 24-h continuous infusion of ifosfamide/mesna in acute lymphoblastic leukemia

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Based on previous reports suggesting that an intravenous (i.v.) continuous infusion of alkylating agents produced a significant response rate in acute lymphoblastic leukemia (ALL), a phase I trial of ifosfamide/mesna (IFO/MES) was conducted in 11 adult patient... ...