Controlling stem cell behavior with decellularized extracellular matrix scaffolds [0.03%]
利用脱细胞基质支架控制干细胞行为
Gillie Agmon,Karen L Christman
Gillie Agmon
Decellularized tissues have become a common regenerative medicine platform with multiple materials being researched in academic laboratories, tested in animal studies, and used clinically. Ideally, when a tissue is decellularized the native...
Amelia A Schendel,Kevin W Eliceiri,Justin C Williams
Amelia A Schendel
Designing electrodes for neural interfacing applications requires deep consideration of a multitude of materials factors. These factors include, but are not limited to, the stiffness, biocompatibility, biostability, dielectric, and conducti...
Materials approaches for modulating neural tissue responses to implanted microelectrodes through mechanical and biochemical means [0.03%]
通过机械和生物化学方法调节植入式微电极诱导的神经组织反应的材料策略
Salah Sommakia,Heui C Lee,Janak Gaire et al.
Salah Sommakia et al.
Implantable intracortical microelectrodes face an uphill struggle for widespread clinical use. Their potential for treating a wide range of traumatic and degenerative neural disease is hampered by their unreliability in chronic settings. A ...
Antimicrobial peptides and induced membrane curvature: geometry, coordination chemistry, and molecular engineering [0.03%]
抗菌肽和诱导膜曲率：几何、配位化学及分子工程学
Nathan W Schmidt,Gerard C L Wong
Nathan W Schmidt
Short cationic, amphipathic antimicrobial peptides are multi-functional molecules that have roles in host defense as direct microbicides and modulators of the immune response. While a general mechanism of microbicidal activity involves the ...
Polymeric Nanomedicines Based on Poly(lactide) and Poly(lactide-co-glycolide) [0.03%]
基于聚乳酸和聚乳酸-co-乙交酯的聚合物纳米药物
Rong Tong,Nathan P Gabrielson,Timothy M Fan et al.
Rong Tong et al.
Small molecule chemotherapeutics often have undesired physiochemical and pharmacological properties, such as low solubility, severe side effect and narrow therapeutic index. To address these challenges, polymeric nanomedicine drug delivery ...
Bo Sun,Yoon Yeo
Bo Sun
Nanocrystals have drawn increasing interest in pharmaceutical industry because of the ability to improve dissolution of poorly water-soluble drugs. Nanocrystals can be produced by top-down and bottom-up technologies and have been explored f...
John B Matson,R Helen Zha,Samuel I Stupp
John B Matson
Self-assembling, peptide-based scaffolds are frontrunners in the search for biomaterials with widespread impact in regenerative medicine. The inherent biocompatibility and cell signaling capabilities of peptides, in combination with control...
Qi Wen,Paul A Janmey
Qi Wen
The cytoskeleton is generally visualized by light or electron microscopy as a meshwork of protein filaments that spans the space between the nuclear envelope and the plasma membrane. In most cell types, this meshwork is formed by a three di...