Yaou Duan,Shuyan Wang,Qiangzhe Zhang et al.
Yaou Duan et al.
Coronavirus disease 2019 (COVID-19), caused by the highly contagious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become the worst pandemic disease of the current millennium. To address this crisis, therapeutic nanopart...
Mechanogenomic coupling of lung tissue stiffness, EMT and coronavirus pathogenicity [0.03%]
肺组织刚度、上皮间质转化和冠状病毒致病性的力学基因组偶联效应
Caroline Uhler,G V Shivashankar
Caroline Uhler
In this Current Opinion, we highlight the importance of the material properties of tissues and how alterations therein, which influence epithelial-to-mesenchymal transitions, represent an important layer of regulation in a number of disease...
Reed E S Harrison,Kegui Weng,Yingxiao Wang et al.
Reed E S Harrison et al.
Liquid-liquid phase separation is increasingly recognized as a phenomenon that affects cell behavior. For example, phase separation of transcription factors and coactivators has been shown to drive efficient transcription. For many years, p...
New perspectives on the roles of nanoscale surface topography in modulating intracellular signaling [0.03%]
纳米级表面拓扑结构在调节细胞内信号转导中的作用的新视角
Wei Zhang,Yang Yang,Bianxiao Cui
Wei Zhang
The physical properties of biomaterials, such as elasticity, stiffness, and surface nanotopography, are mechanical cues that regulate a broad spectrum of cell behaviors, including migration, differentiation, proliferation, and reprogramming...
Getting the big picture of cell-matrix interactions: High-throughput biomaterial platforms and systems-level measurements [0.03%]
细胞-基质相互作用的高通量分析及整体性测量：材料平台与集成体系
Ruoxing Lei,Sanjay Kumar
Ruoxing Lei
Living cells interact with the extracellular matrix (ECM) in a complex and reciprocal manner. Much has been learned over the past few decades about cell-ECM interactions from targeted studies in which a specific matrix parameter (e.g. stiff...
Yang Song,Jennifer Soto,Song Li
Yang Song
Cell plasticity is important in development and tissue remodeling. Cells can sense physical and chemical cues from their local microenvironment and transduce the signals into the nucleus to regulate the epigenetic state and gene expression,...
Degradable Piezoelectric Biomaterials for Wearable and Implantable Bioelectronics [0.03%]
用于可穿戴和植入式生物电子产品的可降解压电生物材料
Jun Li,Yin Long,Fan Yang et al.
Jun Li et al.
Current bioelectronics are facing a paradigm shift from old-fashioned unrecyclable materials to green and degradable functional materials with desired biocompatibility. As an essential electromechanical coupling component in many bioelectro...
Laura A Struzyna,Kritika Katiyar,D Kacy Cullen
Laura A Struzyna
Neural tissue engineers are exploiting key mechanisms responsible for neural cell migration and axonal path finding during embryonic development to create living scaffolds for neuroregeneration following injury and disease. These mechanisms...
Amber M Hilderbrand,Elisa M Ovadia,Matthew S Rehmann et al.
Amber M Hilderbrand et al.
Stem cells reside in complex three-dimensional (3D) environments within the body that change with time, promoting various cellular functions and processes such as migration and differentiation. These complex changes in the surrounding envir...
Integrating Concepts of Material Mechanics, Ligand Chemistry, Dimensionality and Degradation to Control Differentiation of Mesenchymal Stem Cells [0.03%]
结合材料力学、配体化学、维度和降解控制间充质干细胞的分化
Matthew G Haugh,Sarah C Heilshorn
Matthew G Haugh
The role of substrate mechanics in guiding mesenchymal stem cell (MSC) fate has been the focus of much research over the last decade. More recently, the complex interplay between substrate mechanics and other material properties such as lig...