Paradoxical enhancement of oxidative stress-induced DNA damage and impaired redox homeostasis by Glutaredoxin 1 overexpression in human HeLa cells [0.03%]
过量表达谷氧还蛋白1通过增强氧化应激诱导的DNA损伤及破坏还原/氧化态平衡发挥促癌作用
Tingyi Zhao,Takahito Moriwaki,LanYun Yan et al.
Tingyi Zhao et al.
Oxidants, including reactive oxygen species (ROS), oxidize intracellular molecules, such as lipids, proteins and deoxyribonucleic acid (DNA). Cysteine thiol groups in proteins are particularly susceptible to oxidation, forming intra- and in...
Soluble factor-mediated enhancement of cell viability via plasma-induced bystander effects [0.03%]
等离子体诱导旁观者效应介导的可溶性因子增强细胞存活率
Misa Iizawa,Masao Suzuki,Ryo Ono
Misa Iizawa
A previous study has shown that gaseous plasma treatment can induce non-monotonic cellular responses, in which cell viability initially decreases with incubation time after treatment but subsequently increases with longer incubation times. ...
Effects of combination metformin and nintedanib therapy in a mouse model of irradiation-induced pulmonary fibrosis [0.03%]
联合使用美金刚和尼替尼达滨治疗放射诱导的小鼠肺纤维化的疗效研究
Ji-Hun Lee,Han-Bi Jeong,Eun-Seon Yoo et al.
Ji-Hun Lee et al.
Radiation-induced lung injury, a well-recognized complication of thoracic radiotherapy, can progress to pulmonary fibrosis, sharing pathological features with idiopathic pulmonary fibrosis. Although nintedanib is widely used as an antifibro...
Image-guided moderately hypofractionated proton beam therapy for localized prostate cancer: 5-year outcomes of a phase II trial [0.03%]
图像引导的中等分次减量质子治疗局部前列腺癌Ⅱ期临床试验的5年随访结果分析
Takashi Iizumi,Hitoshi Ishikawa,Yuta Sekino et al.
Takashi Iizumi et al.
The purpose of the present study is to confirm the efficacy and feasibility of moderately hypofractionated proton beam therapy (PBT) at a total dose of 63 Gy relative biological effectiveness (RBE) in 21 fractions for prostate cancer. This ...
The feasibility and toxicity of the second course of boron neutron capture therapy in recurrent head and neck cancer patients [0.03%]
复发性头颈部肿瘤患者二次接受硼中子俘获治疗的可行性和毒性分析
Yoshiaki Takagawa,Yoshihiro Takai,Takashi Ono et al.
Yoshiaki Takagawa et al.
The feasibility and safety of a second course of boron neutron capture therapy (BNCT) are unknown. In this study, we retrospectively analyzed the treatment outcomes and toxicities in recurrent head and neck cancer (RHNC) patients who underw...
Prospective feasibility study of diagnostic CT-based simulation-free palliative radiotherapy [0.03%]
基于诊断性CT的姑息放疗验证免模拟定位的可行性研究
Takeshi Kashiwagi,Kiyonao Nakamura,Kazunori Tanaka et al.
Takeshi Kashiwagi et al.
Conventional radiotherapy (RT) workflows require planning computed tomography (pCT) and treatment planning. However, these processes often take several days, leading to delays in RT initiation. Simulation-free radiotherapy (SFRT), which use...
Dosimetric evaluation of patient-side range shifters using two materials for superficial region treatment in spot scanning proton therapy: impact of material, air gap and setup distance [0.03%]
点扫描质子治疗浅层区域治疗时使用两种材料的患者侧射程调节器的剂量学评价：材料、空气间隙和设置距离的影响
Seiichi Ota,Tomohiro Kajikawa,Toshiyuki Ogata et al.
Seiichi Ota et al.
This study aimed to evaluate the dosimetric characteristics of patient-side range shifters (RS) made of polymethyl methacrylate and high-density polyethylene for superficial region treatment in spot scanning proton therapy. The impact of ai...
Methodological considerations on the estimation of non-initial radiation effects among Hiroshima atomic bomb survivors: a commentary on Ohtaki et al. (2025) [0.03%]
关于广岛原子弹幸存者二次辐射效应估计的方法学考虑：对Ohtaki等（2025）的评论
Hideto Takahashi,Koji Ono
Hideto Takahashi
A recent study by Ohtaki et al. (Frontiers in Public Health, 2025) proposed that non-initial (residual) radiation contributed substantially to solid cancer mortality among Hiroshima atomic bomb survivors, estimating residual radiation doses...
Relationship between rectal bleeding and radiation delivery time in intensity-modulated radiotherapy for localized prostate cancer: a preliminary study [0.03%]
调强放疗治疗局限性前列腺癌的直肠出血与放疗时间的关系：一项初步研究
Nozomi Kita,Natsuo Tomita,Taiki Takaoka et al.
Nozomi Kita et al.
The present study investigated the relationship between late grade ≥ 2 rectal bleeding and radiation delivery time in intensity-modulated radiotherapy (IMRT) for localized prostate cancer. We analyzed patients with localized prostate cance...
The role of cytosolic mitochondrial DNA as a mitochondrial danger signal for stromal fibroblasts in forming the tumor-promoting microenvironment following radiation exposure [0.03%]
辐照后线粒体DNA作为细胞质中的危险信号促进成纤维母细胞形成肿瘤微环境的作用机制研究
Tsutomu Shimura
Tsutomu Shimura
Inflammation plays an essential role in detecting foreign pathogens, which triggers a defensive response, eliminates infected tissue and facilitates tissue repair. However, when acute inflammation progresses to chronic inflammation, it cont...