Roles of TIF1β in Leukemic Stem Cell Through SETDB1-Dependent and Independent Mechanisms [0.03%]
TIF1β通过SETDB1依赖和非依赖机制在白血病干细胞中的作用
Mariko Morii,Sho Kubota,Goro Sashida
Mariko Morii
TIF1β/TRIM28/KAP1 has been recognized as a scaffold protein that partners with KRAB-ZFPs and heterochromatin complexes to enforce gene silencing. In embryonic and pluripotent stem cells, it maintains self-renewal by silencing endogenous re...
IAP Antagonists Selectively Eliminate Therapy-Induced Senescent Cancer Cells via TNFα-Independent Apoptosis [0.03%]
选择性地通过TNFα非依赖性的凋亡清除治疗诱导的衰老癌细胞的IAP拮抗剂
Hiroaki Ochiiwa,Takeshi Wakasa,Yuki Kataoka et al.
Hiroaki Ochiiwa et al.
Therapy-induced senescence (TIS) is a state in which cancer cells enter growth arrest following chemotherapy. TIS cancer cells influence the tumor microenvironment through their senescence-associated secretory phenotype and independently ac...
Effect Modification by Cofactors in the Impact of Body Mass Index Change on the Risk of Lung Cancer [0.03%]
体质指数变化影响肺癌风险的混杂因素效应修饰作用研究
Su Youn Nam,Junwoo Jo,Sun Ha Choi
Su Youn Nam
While baseline body mass index (BMI) has been inversely associated with lung cancer risk, the impact of BMI change remains unclear. Furthermore, stratified analysis by menopausal status and age has not been explored. Cancer-free participant...
Clinical Applications of Phosphoproteomics: Illuminating Cancer Signaling and Enabling Rational Therapeutic Strategies [0.03%]
磷酸蛋白质组学的临床应用：阐明癌症信号通路及实现理性治疗策略
Hirokazu Shoji,Narikazu Boku,Jun Adachi
Hirokazu Shoji
Protein phosphorylation is a central post-translational modification regulating cellular signaling, frequently dysregulated in cancer. Mass spectrometry (MS)-based phosphoproteomics has emerged as a powerful approach to systematically profi...
FB23-2 and Cisplatin Synergize to Inhibit Head and Neck Squamous Cell Carcinoma by Targeting the XPF/ERCC1 Complex [0.03%]
FB23-2联合顺铂通过靶向XPF/ERCC1复合体抑制头颈鳞癌协作攻关成果丰富肿瘤学国际主流期刊发表论文
Yaoqi Jiang,Hongshi Cai,Yue Zhu et al.
Yaoqi Jiang et al.
Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive malignancy with a poor prognosis, often necessitating multimodal treatment approaches. While cisplatin (CDDP) remains the first-line chemotherapeutic agent, treatment fail...
Frontline ATRA-ATO Therapy for Acute Promyelocytic Leukemia in Japan: Results From the Prospective Multicenter FBMTG-APL2017 Trial [0.03%]
日本急性早幼粒细胞白血病的一线ATRA-AZO化疗：前瞻性多中心FBMTG-APL2017研究结果
Ken Takase,Tomohiko Kamimura,Takuro Kuriyama et al.
Ken Takase et al.
All-trans retinoic acid (ATRA) combined with arsenic trioxide (ATO) has become the international standard of care for newly diagnosed acute promyelocytic leukemia (APL), demonstrating superior efficacy and safety over ATRA-chemotherapy regi...
Tafasitamab as Monotherapy or in Combination in Japanese Patients With B-Cell Non-Hodgkin Lymphoma: Results From the Phase 1b J-MIND Study [0.03%]
J-MIND研究：塔法西单抗作为单一疗法或联合治疗B细胞非霍奇金淋巴瘤日本患者的疗效和安全性：Ib期临床试验结果
Koji Izutsu,Noriko Fukuhara,Junichiro Yuda et al.
Koji Izutsu et al.
We conducted a phase 1b study evaluating safety and tolerability of tafasitamab, a CD19-targeting immunotherapy, in Japanese patients with B-cell non-Hodgkin lymphoma (NHL). Eligible patients were ≥ 18 years old with relapsed/refractory (R...
Cancer-Specific Antihuman Podoplanin Antibody chLpMab-2f Exerts Antitumor Effects Against Pleural Mesothelioma [0.03%]
抗人Podoplanin单克隆抗体chLpMab-2f对恶性胸膜间皮瘤的治疗作用研究
Aito Yoshida,Shinji Abe,Toshihiro Izumi et al.
Aito Yoshida et al.
Pleural mesothelioma (PM) is a malignancy with a poor prognosis owing to its resistance to chemotherapy. To develop a novel treatment for PM, podoplanin (PDPN), a transmembrane glycoprotein, has attracted significant attention because it is...
Compound Library Screening Identified Cladribine as a Novel Radiosensitizer for Prostate Cancer [0.03%]
化合物库筛选鉴定氯苯酚宁为前列腺癌放射增敏的新药物
Toshiki Oka,Koji Hatano,Shohei Katsuki et al.
Toshiki Oka et al.
Radiation therapy effectively treats prostate cancer, but tumor recurrence remains a clinical challenge, highlighting the need for strategies to enhance radiosensitivity. In this study, we developed a simple, high-throughput drug repurposin...
IRF4 Enhances Radiosensitivity of Cervical Cancer by Inhibiting the PI3K/Akt/mTOR Pathway to Regulate Autophagy [0.03%]
IRF4通过抑制PI3K/Akt/mTOR信号通路调节宫颈癌放射敏感性及自噬作用
Meihui Gao,Zhaolei Cui,Huachun Song et al.
Meihui Gao et al.
Interferon regulatory factor 4 (IRF4), a critical member of the IRF transcription factor family, harbors an elusive biological role in cervical cancer. Through immunohistochemical staining and immunoblotting, CCK-8 viability assays, EdU inc...