Crystals of taka-amylase A, a cornerstone of protein chemistry in Japan [0.03%]
日本蛋白质化学的重要研究对象高麦芽糖酶A的结晶体结构
Saburo Aimoto,Naoto Minamino,Takeshi Ishimizu et al.
Saburo Aimoto et al.
In 1935, Shiro Akabori began research on the preparation of taka-amylase A with a purity suitable for chemical research, with the intention of elucidating the chemical nature of the enzyme. He succeeded in developing a method to efficiently...
Keiko Shimamoto,Kohki Fujikawa,Tsukiho Osawa et al.
Keiko Shimamoto et al.
Regulation of membrane protein integration involves molecular devices such as Sec-translocons or the insertase YidC. We have identified an integration-promoting factor in the inner membrane of Escherichia coli called membrane protein integr...
Kenji Sobue
Kenji Sobue
Calcium ions (Ca2+) play critical roles in various biological phenomena. The free Ca2+ concentration in the cytoplasm of a resting cell is at the 10-7 M level, whereas that outside the cell is 10-3 M, creating a 10,000-fold gradient of Ca2+...
The discovery of acatalasemia (lack of catalase in the blood) and its significance in human genetics [0.03%]
有关血液中缺乏过氧化氢酶（Acatalasemia）的发现及其在人类遗传学上的意义
Mizuo Ando,Kunihiro Fukushima,Kazunori Nishizaki
Mizuo Ando
Catalase, a heme-containing antioxidant enzyme, was once considered essential for human survival. It is widely distributed in the human body and is particularly abundant in red blood cells. The term "acatalasemia" first appeared in the Proc...
Optical coupling of individual air-suspended carbon nanotubes to silicon microcavities [0.03%]
悬浮于空气中的单个碳纳米管与硅微腔的光学耦合
Wataru Terashima,Yuichiro K Kato
Wataru Terashima
Carbon nanotubes are a telecom band emitter compatible with silicon photonics, and when coupled to microcavities, they present opportunities for exploiting quantum electrodynamical effects. Microdisk resonators demonstrate the feasibility o...
Tomoyuki Kitagawa
Tomoyuki Kitagawa
This review seeks to highlight and celebrate Professor Tomizo Yoshida's famous work on "Establishment and characterization of a rat ascites sarcoma, later named "Yoshida ascites sarcoma". Considering the tremendous contribution of this asci...
Transcriptome analysis of the tardigrade Hypsibius exemplaris exposed to the DNA-damaging agent bleomycin [0.03%]
DNA损伤剂Bleomycin诱导水熊虫Hypsibius exemplaris转录组分析
Yuki Yoshida,Akiyoshi Hirayama,Kazuharu Arakawa
Yuki Yoshida
Tardigrades are microscopic animals that are renowned for their capabilities of tolerating near-complete desiccation by entering an ametabolic state called anhydrobiosis. However, many species also show high tolerance against radiation in t...
Chondroitin sulfate proteoglycan 4: An attractive target for antibody-based immunotherapy [0.03%]
硫酸软骨素蛋白聚糖4：抗体免疫治疗的有吸引力的作用靶点
Tomohiro Kurokawa,Kohzoh Imai
Tomohiro Kurokawa
Multifunctional molecules involved in tumor progression and metastasis have been identified as valuable targets for immunotherapy. Among these, chondroitin sulfate proteoglycan 4 (CSPG4), a significant tumor cell membrane-bound proteoglycan...
Hidenori Mimura
Hidenori Mimura
Magnetron production and use far exceed that of other microwave tubes due to their high operational efficiency, power efficiency, and cost-effectiveness in production. The magnetron was named by A. W. Hull; however, the device invented by H...
Perturbed maternal microbiota shapes offspring microbiota during early colonization period in mice [0.03%]
扰动的小鼠母体微生物群形塑后代在早期定植阶段的微生物群
Shiro Tochitani,Takamitsu Tsukahara,Ryo Inoue
Shiro Tochitani
Recent studies have highlighted the impact of disrupted maternal gut microbiota on the colonization of offspring gut microbiota, with implications for offspring developmental trajectories. The extent to which offspring inherit the character...