Hermaphrodism and sex reversal associated with the dominant hemimelia mutation in XY mice [0.03%]
XY型小鼠中与半肢畸形显性突变相关的两性畸形和性别反转现象
Jun-ichi Suto
Jun-ichi Suto
After two generations of backcrossing six different Y-consomic strains onto a C57BL/6J inbred mouse strain with a dominant hemimelia (Dh) mutation, a small percentage of Dh/+ males containing a Y chromosome from the AKR/J or RF/J strain sho...
Various facets of vertebrate cilia: motility, signaling, and role in adult neurogenesis [0.03%]
纤毛的各个方面：运动、信号转导及在成人神经发生中的作用
Shihhui Huang,Yuki Hirota,Kazunobu Sawamoto
Shihhui Huang
Cilia are microtubule-based cellular organelles that are widely distributed in vertebrate tissues. They were first observed hundreds of years ago. Recent studies indicate that this small organelle plays important roles in numerous physiolog...
Transforming growth factor-beta signaling in epithelial-mesenchymal transition and progression of cancer [0.03%]
转化生长因子-β信号在上皮间质转化及癌症进展中的作用
Kohei Miyazono
Kohei Miyazono
Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that induces growth arrest, tissue fibrosis, and epithelial-mesenchymal transition (EMT) through activation of Smad and non-Smad signaling pathways. EMT is the differe...
Rational design of dynamic ammonium salt catalysts towards more flexible and selective function [0.03%]
理性设计动态铵盐催化剂以实现更灵活和选择性的功能转换
Kazuaki Ishihara
Kazuaki Ishihara
This review focuses on the development of dynamic ammonium salt catalysis for selective organic transformations conducted in our laboratory since 2002. Several important concepts in designing of catalysts are described with some examples. I...
Overview on the history of organofluorine chemistry from the viewpoint of material industry [0.03%]
从材料工业视角看有机氟化学的发展历程概述
Takashi Okazoe
Takashi Okazoe
Fluorine (from "le fluor", meaning "to flow") is a second row element of Group 17 in the periodic table. When bound to carbon it forms the strongest bond in organic chemistry to give organofluorine compounds. The scientific field treating t...
Nobuo Shuto,Koji Fujima
Nobuo Shuto
The tsunami science and engineering began in Japan, the country the most frequently hit by local and distant tsunamis. The gate to the tsunami science was opened in 1896 by a giant local tsunami of the highest run-up height of 38 m that cla...
Regulation of succinate-ubiquinone reductase and fumarate reductase activities in human complex II by phosphorylation of its flavoprotein subunit [0.03%]
人复杂II通过其黄素蛋白亚基的磷酸化调节琥珀酸泛醌还原酶和富马酸还原酶活性
Eriko Tomitsuka,Kiyoshi Kita,Hiroyasu Esumi
Eriko Tomitsuka
Complex II (succinate-ubiquinone reductase; SQR) is a mitochondrial respiratory chain enzyme that is directly involved in the TCA cycle. Complex II exerts a reverse reaction, fumarate reductase (FRD) activity, in various species such as bac...
The Ay allele at the agouti locus reduces the size and alters the shape of the mandible in mice [0.03%]
等位基因Ay降低小鼠下颌骨大小并改变其形态
Jun-ichi Suto
Jun-ichi Suto
To confirm my previous findings that the A(y) allele at the agouti locus reduced the mandible size and therefore altered the mandible shape in a KK mouse strain background, I further investigated the effects of the A(y) allele on mandible m...
Recovery of cell nuclei from 15,000 years old mammoth tissues and its injection into mouse enucleated matured oocytes [0.03%]
从1.5万年前的猛犸象组织中恢复细胞核并注入小鼠去核成熟卵母细胞中
Hiromi Kato,Masayuki Anzai,Tasuku Mitani et al.
Hiromi Kato et al.
Here, we report the recovery of cell nuclei from 14,000-15,000 years old mammoth tissues and the injection of those nuclei into mouse enucleated matured oocytes by somatic cell nuclear transfer (SCNT). From both skin and muscle tissues, cel...
Accumulation of radium in ferruginous protein bodies formed in lung tissue: association of resulting radiation hotspots with malignant mesothelioma and other malignancies [0.03%]
肺组织中铁蛋白体中镭的积累：由此产生的辐射热点与恶性间皮瘤及其他肿瘤的关系
Eizo Nakamura,Akio Makishima,Kyoko Hagino et al.
Eizo Nakamura et al.
While exposure to fibers and particles has been proposed to be associated with several different lung malignancies including mesothelioma, the mechanism for the carcinogenesis is not fully understood. Along with mineralogical observation, w...