The first artificial cancer in the internal organs of experimental animals [0.03%]
实验动物内脏人工癌的第一个成功案例
Takao Sekiya
Takao Sekiya
In the world history of cancer research, three achievements in Japan were groundbreaking. First, in 1915, Katsusaburo Yamagiwa and Koichi Ichikawa induced skin cancer on the ears of rabbits by the repeated application of coal tar. This achi...
First report on a series of food-derived mutagenic and carcinogenic heterocyclic amines [0.03%]
食物来源的致突变和致癌杂环胺的第一份研究报告
Yukari Totsuka,Masako Ochiai,Keiji Wakabayashi
Yukari Totsuka
Lifestyle, especially diet, significantly impacts cancer development. Sugimura, T. et al. discovered that grilled fish smoke and charred parts are highly mutagenic in Salmonella typhimurium. They identified two novel mutagenic heterocyclic ...
Report on the mutagenicity of flavone derivatives and their contribution to advancing scientific knowledge [0.03%]
黄酮衍生物致突变性研究报告及其对科学进步的贡献
Yukari Totsuka,Keiji Wakabayashi
Yukari Totsuka
Flavonoids, such as quercetin and kaempferol, and their glycosides, are widely distributed in vegetables and fruits. Sugimura, T. et al. investigated the mutagenicity of flavone derivatives, and found that quercetin and kaempferol showed hi...
Molecular and cellular mechanisms of developmental synapse elimination in the cerebellum: Involvement of autism spectrum disorder-related genes [0.03%]
小脑发育性突触消除的分子和细胞机制：自闭症谱系障碍相关基因的作用
Takaki Watanabe,Masanobu Kano
Takaki Watanabe
Neural circuits are initially created with excessive synapse formation until around birth and undergo massive reorganization until they mature. During postnatal development, necessary synapses strengthen and remain, whereas unnecessary ones...
The spontaneous-diabetes rat: a model of noninsulin dependent diabetes mellitus by Yoshio Goto and Masaei Kakizaki (1981) [0.03%]
_goto和_kakizaki于1981年建立的自发性糖尿病大鼠品系作为非胰岛素依赖型糖尿病动物模型
Hiroo Imura
Hiroo Imura
Y. Goto and M. Kakizaki produced a rat model of non-insulin dependent diabetes mellitus (NIDDM) by repetitive selective breeding of rats with slightly impaired glucose tolerance. In contrast to most obese diabetes models, which were genetic...
Masaru Kono
Masaru Kono
In 1929, Matuyama published his paper on the magnetization of mostly Quaternary volcanic rocks. In this paper, he described the results of paleomagnetic measurements of volcanic rocks from Japan and nearby areas and concluded that the lates...
Incorporation of photosynthetically active algal chloroplasts in cultured mammalian cells towards photosynthesis in animals [0.03%]
将光合藻类叶绿体整合进哺乳动物培养细胞朝向动物光合作用方向前进
Ryota Aoki,Yayoi Inui,Yoji Okabe et al.
Ryota Aoki et al.
Chloroplasts are photosynthetic organelles that evolved through the endosymbiosis between cyanobacteria-like symbionts and hosts. Many studies have attempted to isolate intact chloroplasts to analyze their morphological characteristics and ...
Imaging-based chemogenetics for dissecting neural circuits in nonhuman primates [0.03%]
基于影像的化学遗传技术在非人灵长类动物神经环路剖析中的应用
Takafumi Minamimoto,Yuji Nagai,Kei Oyama
Takafumi Minamimoto
Nonhuman primates, particularly macaque and marmoset monkeys, serve as invaluable models for studying complex brain functions and behavior. However, the lack of suitable genetic neuromodulation tools has constrained research at the network ...
Whole-genome sequencing analysis of volvocine green algae reveals the molecular genetic basis for the diversity and evolution of sex [0.03%]
卷须绿藻全基因组测序分析揭示了性别的多样性和进化分子遗传基础
Hisayoshi Nozaki,Kayoko Yamamoto,Kohei Takahashi
Hisayoshi Nozaki
This review describes the development of evolutionary studies of sex based on the volvocine lineage of green algae, which was facilitated by whole-genome analyses of both model and non-model species. Volvocine algae, which include Chlamydom...
Tracing the genealogy of research on the mechanism of blue flower coloration by anthocyanin based on Keita Shibata's work [0.03%]
基于柴野敬太研究的花青素蓝色花朵色素机制研究系谱追溯
Kumi Yoshida
Kumi Yoshida
K. Shibata is the ancestor of the research on anthocyanins in Japan and proposed metal complex theory against the pH theory by R. Willstätter. Shibata's successors, S. Hattori and K. Hayashi, made efforts to clarify blue flower coloration ...