Akira Endo
Akira Endo
Cholesterol is essential for the functioning of all human organs, but it is nevertheless the cause of coronary heart disease. Over the course of nearly a century of investigation, scientists have developed several lines of evidence that est...
Masahiro Irie
Masahiro Irie
Photochromism is defined as a reversible transformation of a chemical species between two isomers upon photoirradiation. Although vast numbers of photochromic molecules have been so far reported, photochromic molecules which exhibit thermal...
Mechanisms of organelle division and inheritance and their implications regarding the origin of eukaryotic cells [0.03%]
细胞器分裂与遗传机制及其对真核细胞起源的启示
Tsuneyoshi Kuroiwa
Tsuneyoshi Kuroiwa
Mitochondria and plastids have their own DNAs and are regarded as descendants of endosymbiotic prokaryotes. Organellar DNAs are not naked in vivo but are associated with basic proteins to form DNA-protein complexes (called organelle nuclei)...
Leo Esaki,Masatoshi Kitamura,Satoshi Iwamoto et al.
Leo Esaki et al.
We report, as the result of shelf-life tests for Esaki diodes, the observation of minute but tangible reductions in the tunnel current after the lapse of half a century. The reduction could be attributed to 0.25% widening in the tunnel path...
Neural stem cells and strategies for the regeneration of the central nervous system [0.03%]
神经干细胞和中枢神经系统再生策略
Hideyuki Okano
Hideyuki Okano
The adult mammalian central nervous system (CNS), especially that of adult humans, is a representative example of organs that do not regenerate. However, increasing interest has focused on the development of innovative therapeutic methods t...
Kentaro Hanada
Kentaro Hanada
The transport and sorting of lipids are fundamental to membrane biogenesis. In the synthesis of sphingolipids in mammalian cells, ceramide is newly produced at the endoplasmic reticulum (ER), and transported from the ER to the trans Golgi r...
Midkine, a heparin-binding cytokine with multiple roles in development, repair and diseases [0.03%]
.midkine：一种具有多种作用的肝素结合细胞因子，在发育、修复和疾病中的作用
Takashi Muramatsu
Takashi Muramatsu
Midkine is a heparin-binding cytokine or a growth factor with a molecular weight of 13 kDa. Midkine binds to oversulfated structures in heparan sulfate and chondroitin sulfate. The midkine receptor is a molecular complex containing proteogl...
Coordinated regulation of circadian rhythms and homeostasis by the suprachiasmatic nucleus [0.03%]
视交叉上核对昼夜节律和稳态的协调调节
Hachiro Nakagawa,Nobuaki Okumura
Hachiro Nakagawa
We have demonstrated that in rats activities of various enzymes related to gluconeogenesis and amino acid metabolism show circadian rhythms. Based on these results, we have explored the molecular mechanisms underlying circadian oscillation ...
Sumihiro Hase
Sumihiro Hase
Herein, I describe pyridylamination for versatile analysis of sugar chains. The reducing ends of the sugar chains are tagged with 2-aminopyridine and the resultant chemically stable fluorescent derivatives are used for structural/functional...
Clinical studies on rising and re-rising neurological diseases in Japan--a personal contribution [0.03%]
日本立现发与再立现发的临床研究-个人贡献报告
Akihiro Igata
Akihiro Igata
Throughout my research life, I experienced to discover the causes of some neurological diseases in Japan. 1) SMON (subacute myelo-optico-neuropathy). Since the early 1960s, a peculiar neurological disease became prevalent throughout Japan. ...