Cell adhesion molecules nectins and associating proteins: Implications for physiology and pathology [0.03%]
粘附分子nectin及其相关蛋白：生理与病理意义
Hisakazu Ogita,Yoshiyuki Rikitake,Jun Miyoshi et al.
Hisakazu Ogita et al.
Nectins have recently been identified as new cell adhesion molecules (CAMs) consisting of four members. They show immunoglobulin-like structures and exclusively localize at adherens junctions (AJs) between two neighboring cells. During the ...
Semaphorins and their receptors: novel features of neural guidance molecules [0.03%]
新神经导向分子及其受体：独有特征
Atsushi Kumanogoh,Hitoshi Kikutani
Atsushi Kumanogoh
Semaphorins were originally identified as axon guidance cues involved in the development of the nervous system. In recent years, it is emerging that they also participate in various biological systems, including physiological and pathologic...
The discovery of hepatocyte growth factor (HGF) and its significance for cell biology, life sciences and clinical medicine [0.03%]
肝细胞生长因子(HGF)的发现及其对细胞生物学、生命科学和临床医学的意义
Toshikazu Nakamura,Shinya Mizuno
Toshikazu Nakamura
It has been more than 25 years since HGF was discovered as a mitogen of hepatocytes. HGF is produced by stromal cells, and stimulates epithelial cell proliferation, motility, morphogenesis and angiogenesis in various organs via tyrosine pho...
The trail of my studies on glycoproteins from enterokinase to tumor markers [0.03%]
从肠激酶到肿瘤标志物——糖蛋白研究之路
Ikuo Yamashina
Ikuo Yamashina
This review describes the results of the author's studies on glycoproteins which have been carried out for more than 50 years. Starting from the elucidation of basic structures of glycoproteins, i.e. the structure of the linkage between an ...
Pancreatic beta-cell signaling: toward better understanding of diabetes and its treatment [0.03%]
胰岛β细胞信号转导：更好地理解糖尿病及其治疗方法
Susumu Seino,Tadao Shibasaki,Kohtaro Minami
Susumu Seino
Pancreatic beta-cells play a central role in the maintenance glucose homeostasis by secreting insulin, a key hormone that regulates blood glucose levels. Dysfunction of the beta-cells and/or a decrease in the beta-cell mass are associated c...
Sogo Okamura,Tomohiro Oguchi
Sogo Okamura
This paper summarizes our study on microwave and millimeter-wave propagation in rain with special emphasis on the effects of polarization. Starting from a recount of our past findings, we will discuss developments with these and how they ar...
Key structures of bacterial peptidoglycan and lipopolysaccharide triggering the innate immune system of higher animals: Chemical synthesis and functional studies" [0.03%]
触发高等动物先天免疫系统的细菌肽聚糖和脂多糖的主要结构：化学合成及功能研究
Shoichi Kusumoto,Koichi Fukase,Tetsuo Shiba
Shoichi Kusumoto
Chemistry-based investigation is reviewed which led to identification of the active entities responsible for the immunostimulating potencies of peptidoglycan and lipopolysaccharide. Though these glycoconjugates which ubiquitously occur in w...
Masayuki Amagai
Masayuki Amagai
Desmosomes are intercellular adhesive junctions of epithelial cells that contain two major transmembrane components, the desmogleins (Dsg) and desmocollins (Dsc), which are cadherin-type cell-cell adhesion molecules and are anchored to inte...
Phosphoinositide-binding interface proteins involved in shaping cell membranes [0.03%]
参与塑形细胞膜的磷脂肌醇结合界面蛋白
Tadaomi Takenawa
Tadaomi Takenawa
The mechanism by which cell and cell membrane shapes are created has long been a subject of great interest. Among the phosphoinositide-binding proteins, a group of proteins that can change the shape of membranes, in addition to the phosphoi...
N-myristoylated proteins, key components in intracellular signal transduction systems enabling rapid and flexible cell responses [0.03%]
N-十四烷酰蛋白在细胞信号转导系统中的作用及意义
Nobuhiro Hayashi,Koiti Titani
Nobuhiro Hayashi
N-myristoylation, one of the co- or post-translational modifications of proteins, has so far been regarded as necessary for anchoring of proteins to membranes. Recently, we have revealed that N(alpha)-myristoylation of several brain protein...