Procyanidins are potent inhibitors of LOX-1: a new player in the French Paradox [0.03%]
原花青素是LOX-1强效抑制剂：法国悖论中出现的新角色
Taichi Nishizuka,Yoshiko Fujita,Yuko Sato et al.
Taichi Nishizuka et al.
Lectin-like oxidized LDL receptor-1 (LOX-1) is an endothelial receptor for oxidized LDL (oxLDL) and plays multiple roles in the development of cardiovascular diseases. We screened more than 400 foodstuff extracts for identifying materials t...
A proposal of a novel experimental procedure to genetically identify disease gene loci in humans [0.03%]
一种新的实验程序的设想以从基因上确定人类疾病基因的位置
Taro Muto
Taro Muto
Forward genetics in humans is beneficial in terms of diagnosis and treatment of genetic diseases, and discovery of gene functions. However, experimental mating is not possible among humans. In order to overcome this problem, I propose a nov...
Exploring the mechanisms of renoprotection against progressive glomerulosclerosis [0.03%]
探索保护肾脏免受进行性系膜增生的影响机制
Takashi Oite
Takashi Oite
In this review, I introduce the strategy developed by our laboratory to explore the mechanisms of renoprotection against progressive glomerulosclerosis leading to renal death. First, I describe the experimental rat model in which disturbanc...
Green tea polyphenol sensing [0.03%]
绿茶多酚检测
Hirofumi Tachibana
Hirofumi Tachibana
Green tea polyphenols have emerged over the past two decades as an important dietary factor for health promotion. There is considerable evidence that tea polyphenols, in particular (-)-epigallocatechin-3-gallate (EGCG) inhibit carcinogenesi...
Development of modified nucleosides that have supremely high anti-HIV activity and low toxicity and prevent the emergence of resistant HIV mutants [0.03%]
高效低毒并能预防艾滋病病毒产生耐药突变的新型核苷类似物的研究开发
Hiroshi Ohrui
Hiroshi Ohrui
An idea to use 4'-C-substituted-2'-deoxynucleoside derivatives was proposed based on a working hypothesis to solve the problems of existing acquired immune deficiency syndrome chemotherapy (highly active antiretroviral therapy). Subsequent ...
Studies on sea snake venom [0.03%]
海蛇毒的研究
Nobuo Tamiya,Tatsuhiko Yagi
Nobuo Tamiya
Erabutoxins a and b are neurotoxins isolated from venom of a sea snake Laticauda semifasciata (erabu-umihebi). Amino acid sequences of the toxins indicated that the toxins are members of a superfamily consisting of short and long neurotoxin...
Structure-based development of specific inhibitors for individual cathepsins and their medical applications [0.03%]
基于结构的针对单个组织蛋白酶的特异性抑制剂的开发及其医学应用
Nobuhiko Katunuma
Nobuhiko Katunuma
Specific inhibitors for individual cathepsins have been developed based on their tertiary structures of X-ray crystallography. Cathepsin B-specific inhibitors, CA-074 and CA-030, and cathepsin L specific inhibitors, CLIK-148 and CLIK-195, w...
Andy Crump,Satoshi Ōmura
Andy Crump
Discovered in the late-1970s, the pioneering drug ivermectin, a dihydro derivative of avermectin--originating solely from a single microorganism isolated at the Kitasato Institute, Tokyo, Japan from Japanese soil--has had an immeasurably be...
Vibrio parahaemolyticus, enterotoxigenic Escherichia coli, enterohemorrhagic Escherichia coli and Vibrio cholerae [0.03%]
副溶血性弧菌、产肠毒素大肠杆菌、出血性大肠杆菌和霍乱弧菌
Yoshifumi Takeda
Yoshifumi Takeda
This review highlighted the following: (i) pathogenic mechanism of the thermostable direct hemolysin produced by Vibrio parahaemolyticus, especially on its cardiotoxicity, (ii) heat-labile and heat-stable enterotoxins produced by enterotoxi...
Molecules participating in insect immunity of Sarcophaga peregrina [0.03%]
参与Sarcophaga peregrina免疫的分子
Shunji Natori
Shunji Natori
Pricking the body wall of Sarcophaga peregrina (flesh fly) larvae with a needle activated the immune system of this insect and induced various immune molecules, including antibacterial proteins, in the hemolymph. In this review, I summarize...