Role of the transcription factor Bcl11b in development and lymphomagenesis [0.03%]
转录因子Bcl11b在发育和淋巴瘤发生中的作用
Ryo Kominami
Ryo Kominami
Bcl11b is a lineage-specific transcription factor expressed in various cell types and its expression is important for development of T cells, neurons and others. On the other hand, Bcl11b is a haploinsufficient tumor suppressor and loss of ...
Vascular permeability in cancer and infection as related to macromolecular drug delivery, with emphasis on the EPR effect for tumor-selective drug targeting [0.03%]
与大分子药物传输相关的癌症和感染中的血管通透性以及基于EPR效应的肿瘤选择性药物靶向作用
Hiroshi Maeda
Hiroshi Maeda
Tumor and inflammation have many common features. One hallmark of both is enhanced vascular permeability, which is mediated by various factors including bradykinin, nitric oxide (NO), peroxynitrite, prostaglandins etc. A unique characterist...
Two distinct pathways for essential metabolic precursors for isoprenoid biosynthesis [0.03%]
异戊二烯生物合成的两种必需代谢底物的途径
Tomohisa Kuzuyama,Haruo Seto
Tomohisa Kuzuyama
Isoprenoids are a diverse group of molecules found in all organisms, where they perform such important biological functions as hormone signaling (e.g., steroids) in mammals, antioxidation (e.g., carotenoids) in plants, electron transport (e...
Analysis of glycoprotein processing in the endoplasmic reticulum using synthetic oligosaccharides [0.03%]
利用合成寡糖分析内质网中糖蛋白的加工过程
Yukishige Ito,Yoichi Takeda
Yukishige Ito
Protein quality control (QC) in the endoplasmic reticulum (ER) comprises many steps, including folding and transport of nascent proteins as well as degradation of misfolded proteins. Recent studies have revealed that high-mannose-type glyca...
Satoshi Ishii
Satoshi Ishii
Fabry disease is an inherited lysosomal storage disorder caused by deficient α-galactosidase A activity. Many missense mutations in Fabry disease often cause misfolded gene products, which leads to their retention in the endoplasmic reticu...
Peculiarity of methoxy group-substituted phenylhydrazones in Fischer indole synthesis [0.03%]
甲氧基取代苯腙类化合物在 Fisher 醌合成中的特殊性
Yasuoki Murakami
Yasuoki Murakami
We found that the Fischer indole synthesis of ethyl pyruvate 2-methoxyphenylhydrazone (5) with HCl/EtOH gave an abnormal product, ethyl 6-chloroindole-2-carboxylate (7), as the main product, with a smaller amount of ethyl 7-methoxyindole-2-...
Alteration in the plasma concentration of a DAAO inhibitor, 3-methylpyrazole-5-carboxylic acid, in the ketamine-treated rats and the influence on the pharmacokinetics of plasma D-tryptophan [0.03%]
氯胺酮处理的大鼠血浆中DAAO抑制剂5-羧基-3-甲基吡唑浓度的变化及其对血浆D-色氨酸药代动力学的影响
Naomi Haruta,Hideaki Iizuka,Kana Ishii et al.
Naomi Haruta et al.
A determination method for 3-methylpyrazole-5-carboxylic acid (MPC), an inhibitor of D-amino acid oxidase (DAAO), in rat plasma was developed by using high-performance liquid chromatography-mass spectrometry (LC-MS). The structural isomer o...
Tsuneo Omura
Tsuneo Omura
Since the publication of the first paper on "cytochrome P450" in 1962, the biochemical research on this novel hemoprotein expanded rapidly in the 1960s and the 1970s as its principal roles in various important metabolic processes including ...
Daniel J Capon,Naoki Kaneko,Takayuki Yoshimori et al.
Daniel J Capon et al.
There is a significant need for antibodies that can bind targets with greater affinity. Here we describe a novel strategy employing chemical semisynthesis to produce symmetroadhesins: antibody-like molecules having nonprotein hinge regions ...
Tadayuki Imanaka
Tadayuki Imanaka
I reflect on some of our studies on the hyperthermophilic archaeon, Thermococcus kodakarensis KOD1 and its enzymes. The strain can grow at temperatures up to 100 °C, and also represents one of the simplest forms of life. As expected, all e...