Influenza virus pathogenicity regulated by host cellular proteases, cytokines and metabolites, and its therapeutic options [0.03%]
流感病毒的致病性受宿主细胞蛋白酶、细胞因子和代谢物调控及其治疗选择方案
Hiroshi Kido
Hiroshi Kido
Influenza A virus (IAV) causes significant morbidity and mortality. The knowledge gained within the last decade on the pandemic IAV(H1N1)2009 improved our understanding not only of the viral pathogenicity but also the host cellular factors ...
Mechanism of the calcium-regulation of muscle contraction--in pursuit of its structural basis [0.03%]
钙离子调节肌肉收缩机制研究——结构基础探索方面的工作
Takeyuki Wakabayashi
Takeyuki Wakabayashi
The author reviewed the research that led to establish the structural basis for the mechanism of the calcium-regulation of the contraction of striated muscles. The target of calcium ions is troponin on the thin filaments, of which the main ...
Strength and precision of neurotransmission at mammalian presynaptic terminals [0.03%]
哺乳动物突触前末端神经递质传递的强度和精确性
Tomoyuki Takahashi
Tomoyuki Takahashi
Classically, the basic concept of chemical synaptic transmission was established at the frog neuromuscular junction, and direct intracellular recordings from presynaptic terminals at the squid giant presynaptic terminal have further clarifi...
Discovery of NKT cells and development of NKT cell-targeted anti-tumor immunotherapy [0.03%]
NKT细胞的发现及其抗肿瘤免疫治疗的发展
Masaru Taniguchi,Michishige Harada,Nyambayar Dashtsoodol et al.
Masaru Taniguchi et al.
Natural Killer T (NKT) cells are unique lymphocytes characterized by their expression of a single invariant antigen receptor encoded by Vα14Jα18 in mice and Vα24Jα18 in humans, which recognizes glycolipid antigens in association with th...
The origin of Cretaceous black shales: a change in the surface ocean ecosystem and its triggers [0.03%]
白垩纪黑色页岩的起源：海洋表面生态系统及其触发机制的变化
Naohiko Ohkouchi,Junichiro Kuroda,Asahiko Taira
Naohiko Ohkouchi
Black shale is dark-colored, organic-rich sediment, and there have been many episodes of black shale deposition over the history of the Earth. Black shales are source rocks for petroleum and natural gas, and thus are both geologically and e...
Characteristics of the 2011 Tohoku Tsunami and introduction of two level tsunamis for tsunami disaster mitigation [0.03%]
2011年东北海啸特征及两级海啸理论在海啸减灾中的应用介绍
Shinji Sato
Shinji Sato
Characteristics of the 2011 Tohoku Tsunami have been revealed by collaborative tsunami surveys extensively performed under the coordination of the Joint Tsunami Survey Group. The complex behaviors of the mega-tsunami were characterized by t...
Yoshio Okamoto
Yoshio Okamoto
Helical structures are chiral, which means that if we can synthesize a polymer having a stable one-handed helicity, the polymer is optically active. In 1979, we succeeded in the synthesis of a one-handed helical polymer from an optically in...
Laser-driven electron beam and radiation sources for basic, medical and industrial sciences [0.03%]
用于基础、医疗和工业科学的激光驱动电子束及辐射源
Kazuhisa Nakajima
Kazuhisa Nakajima
To date active research on laser-driven plasma-based accelerators have achieved great progress on production of high-energy, high-quality electron and photon beams in a compact scale. Such laser plasma accelerators have been envisaged bring...
Hisashi Utada
Hisashi Utada
Electromagnetic exploration is a geophysical method for examining the Earth's interior through observations of natural or artificial electromagnetic field fluctuations. The method has been in practice for more than 70 years, and 40 years ag...
The EML4-ALK oncogene: targeting an essential growth driver in human cancer [0.03%]
EML4-ALK致癌基因：靶向人类癌症中的一个生长驱动因素
Hiroyuki Mano
Hiroyuki Mano
Targeting of essential growth drivers represents an ideal approach to cancer treatment. To identify such molecules in clinical specimens, we developed a highly sensitive functional screening system based on the preparation of retroviral cDN...