Toshio Yanagida,Yoshiharu Ishii
Toshio Yanagida
Single molecule detection has contributed to our understanding of the unique mechanisms of life. Unlike artificial man-made machines, biological molecular machines integrate thermal noises rather than avoid them. For example, single molecul...
Koji Uenishi
Koji Uenishi
Normally, an earthquake is considered as a phenomenon of wave energy radiation by rupture (fracture) of solid Earth. However, the physics of dynamic process around seismic sources, which may play a crucial role in the occurrence of earthqua...
Folding of apomyoglobin: Analysis of transient intermediate structure during refolding using quick hydrogen deuterium exchange and NMR [0.03%]
脱辅基肌红蛋白折叠：利用快速氢氘交换和NMR分析复性过程中瞬态中间结构
Chiaki Nishimura
Chiaki Nishimura
The structures of apomyoglobin folding intermediates have been widely analyzed using physical chemistry methods including fluorescence, circular dichroism, small angle X-ray scattering, NMR, mass spectrometry, and rapid mixing. So far, at l...
Shaw Watanabe
Shaw Watanabe
The prevalence of chronic kidney disease (CKD) is estimated to be 8-16% worldwide, and it is increasing. CKD is a risk factor for heart attack and stroke, and it can progress to kidney failure requiring dialysis or transplantation. Recently...
Both the transglycosylase and transpeptidase functions in plastid penicillin-binding protein are essential for plastid division in Physcomitrella patens [0.03%]
壶菌藻血凝素结合蛋白的转糖基化酶和转肽酶功能对Physcomitrella patens细胞分裂均是必不可少的
Yoshiko Takahashi,Katsuaki Takechi,Susumu Takio et al.
Yoshiko Takahashi et al.
Class A penicillin-binding proteins (PBPs) are active in the final step of bacterial peptidoglycan biosynthesis. They possess a transglycosylase (TG) domain to polymerize the glycan chains and a transpeptidase (TP) domain to catalyze peptid...
Calcium inhibition as an intracellular signal for actin-myosin interaction [0.03%]
钙抑制作为肌动蛋白-肌球蛋白相互作用的细胞内信号
Kazuhiro Kohama
Kazuhiro Kohama
Intracellular signaling pathways include both the activation and the inhibition of biological processes. The activation of Ca2+ regulation of actin-myosin interactions was examined first, whereas it took 20 years for the author to clarify t...
Yukio Fujiki
Yukio Fujiki
Peroxisome is a single-membrane-bounded ubiquitous organelle containing a hundred different enzymes that catalyze various metabolic pathways such as β-oxidation of very long-chain fatty acids and synthesis of plasmalogens. To investigate p...
Silent evolution [0.03%]
悄然演变
Syozo Osawa,Zhi-Hui Su,Masaaki Nishikawa et al.
Syozo Osawa et al.
Phylogenetic analyses using mitochondrial DNA sequences of several kinds of beetles have shown that their evolution included a silent stage in which no morphological changes took place. We thus propose a new category of evolutionary process...
CXCL12 protects pancreatic β-cells from oxidative stress by a Nrf2-induced increase in catalase expression and activity [0.03%]
CXCL12通过Nrf2诱导的过氧化氢酶表达和活性增加保护胰腺β细胞免受氧化应激损害
Svetlana Dinić,Nevena Grdović,Aleksandra Uskoković et al.
Svetlana Dinić et al.
Due to intrinsically low levels of antioxidant enzyme expression and activity, insulin producing pancreatic β-cells are particularly susceptible to free radical attack. In diabetes mellitus, which is accompanied by high levels of oxidative...
Ryu Okumura,Kiyoshi Takeda
Ryu Okumura
Inflammatory bowel diseases (IBD) are represented by ulcerative colitis (UC) and Crohn's disease (CD), both of which involve chronic intestinal inflammation. Recent evidence has indicated that gut immunological homeostasis is maintained by ...