Engineering the lodging resistance mechanism of post-Green Revolution rice to meet future demands [0.03%]
工程改造水稻抗倒伏机制以应对未来需求
Ko Hirano,Reynante Lacsamana Ordonio,Makoto Matsuoka
Ko Hirano
Traditional breeding for high-yielding rice has been dependent on the widespread cultivation of gibberellin (GA)-deficient semi-dwarf varieties. Dwarfism lowers the "center of gravity" of the plant body, which increases resistance against l...
Structure and function of Helicobacter pylori CagA, the first-identified bacterial protein involved in human cancer [0.03%]
幽门螺杆菌蛋白Caga的结构和功能及其与人类癌症的关系研究
Masanori Hatakeyama
Masanori Hatakeyama
Chronic infection with Helicobacter pylori cagA-positive strains is the strongest risk factor of gastric cancer. The cagA gene-encoded CagA protein is delivered into gastric epithelial cells via bacterial type IV secretion, where it undergo...
Akira Takeda,Naoko Sasaki,Masayuki Miyasaka
Akira Takeda
Lymphocyte recirculation between the blood and the lymphoid/non-lymphoid tissues is an essential homeostatic mechanism that regulates humoral and cellular immune responses in vivo. This system promotes the encounter of naïve T and B cells ...
Purinergic signaling in microglia in the pathogenesis of neuropathic pain [0.03%]
微胶质细胞中嘌呤能信号在神经病理性疼痛发病机制中的作用
Kazuhide Inoue
Kazuhide Inoue
Nerve injury often causes debilitating chronic pain, referred to as neuropathic pain, which is refractory to currently available analgesics including morphine. Many reports indicate that activated spinal microglia evoke neuropathic pain. Th...
Dual role of cellular prion protein in normal host and Alzheimer's disease [0.03%]
细胞源性朊蛋白在正常宿主和阿尔茨海默病中的双重作用
Takashi Onodera
Takashi Onodera
Using PrPC-knockout cell lines, it has been shown that the inhibition of apoptosis through STI1 is mediated by PrPC-dependent SOD activation. Antioxidant PrPC may contribute to suppression of inflammasome activation. PrPC is functionally in...
Masahito Hayashi
Masahito Hayashi
Coding technology is used in several information processing tasks. In particular, when noise during transmission disturbs communications, coding technology is employed to protect the information. However, there are two types of coding techn...
Getting to the heart of the matter in cancer: Novel approaches to targeting cancer stem cells [0.03%]
直击癌症要害：靶向作用癌细胞的新型策略
Hugh Colvin,Masaki Mori
Hugh Colvin
Cancer is one of the leading causes of deaths worldwide. While cancers may initially show good response to chemotherapy or radiotherapy, it is not uncommon for them to recur at a later date. This phenomenon may be explained by the existence...
Shin-Ichiro Shoda
Shin-Ichiro Shoda
Glycosidic compounds are indispensable molecules in living systems. Biological phenomena such as cell wall formation, energy storage, and cell recognition strongly depend on the multi-functional characters of these substances. Development o...
Takashi Sakurai
Takashi Sakurai
The solar corona is a tenuous outer atmosphere of the Sun. Its million-degree temperature was discovered spectroscopically in the 1940s, but its origin has been debated since then without complete convergence. Currently there are two classe...
Johannes F G Vliegenthart
Johannes F G Vliegenthart
A brief review is presented of our studies on the structure of glycoprotein-derived glycans. The emphasis is on the introduction of high-resolution 1H-NMR spectroscopy for the unambiguous determination of primary structures. For this purpos...