Emerging mechanisms underlying astrogenesis in the developing mammalian brain [0.03%]
哺乳动物大脑发育过程中星形胶质细胞发生的分子机制研究进展
Jun Takouda,Sayako Katada,Kinichi Nakashima
Jun Takouda
In the developing brain, the three major cell types, i.e., neurons, astrocytes and oligodendrocytes, are generated from common multipotent neural stem cells (NSCs). In particular, astrocytes eventually occupy a great fraction of the brain a...
Molecular mechanisms and physiological roles of Atg5/Atg7-independent alternative autophagy [0.03%]
独立于Atg5/Atg7的替代自噬的分子机制及其生理作用
Satoko Arakawa,Shinya Honda,Hirofumi Yamaguchi et al.
Satoko Arakawa et al.
ATG5 and ATG7 are considered to be essential molecules for the induction of autophagy. However, we found that cells lacking ATG5 or ATG7 can still form autophagosomes/autolysosomes and perform autophagic protein degradation when subjected t...
Ultra-Early Phase pathologies of Alzheimer's disease and other neurodegenerative diseases [0.03%]
阿尔茨海默病和其他神经退行性疾病的极早期病理学
Hitoshi Okazawa
Hitoshi Okazawa
The concept of neurodegenerative diseases and the therapeutics targeting these intractable diseases are changing rapidly. Protein aggregation as the top of pathological cascade is now challenged, and many alternative ideas are proposed. Ear...
Isamu Miyakawa
Isamu Miyakawa
Mitochondrial DNA (mtDNA) is packaged by association with specific proteins in compact DNA-protein complexes named mitochondrial nucleoids (mt-nucleoids). The budding yeast Saccharomyces cerevisiae is able to grow either aerobically or anae...
Days weaving the lagging strand synthesis of DNA - A personal recollection of the discovery of Okazaki fragments and studies on discontinuous replication mechanism [0.03%]
DNA滞后链合成的那些日子——大泽片段发现及复制机制研究的个人回忆
Tsuneko Okazaki
Tsuneko Okazaki
At DNA replication forks, the overall growth of the antiparallel two daughter DNA chains appears to occur 5'-to-3' direction in the leading-strand and 3'-to-5' direction in the lagging-strand using enzyme system only able to elongate 5'-to-...
Minoru Yoshida,Norio Kudo,Saori Kosono et al.
Minoru Yoshida et al.
Histone acetylation is a reversible posttranslational modification that plays a fundamental role in regulating eukaryotic gene expression and chromatin structure/function. Key enzymes for removing acetyl groups from histones are metal (zinc...
Takahiro Hara
Takahiro Hara
Research on mobile ad hoc networks (MANETs) has become a hot research topic since the middle 1990's. Over the first decade, most research focused on networking techniques, ignoring data management issues. We, however, realized early the imp...
Molecular investigations of development and diseases of the brain of higher mammals using the ferret [0.03%]
用银朱研究高级哺乳动物大脑的发育和疾病的相关分子机制
Hiroshi Kawasaki
Hiroshi Kawasaki
The brains of higher mammals such as primates and carnivores contain well-developed unique brain structures. Uncovering the physiological functions, developmental mechanisms and evolution of these brain structures would greatly facilitate o...
Multiple system atrophy: clinicopathological characteristics in Japanese patients [0.03%]
多系统萎缩的临床病理特征(日本患者的资料)
Tetsutaro Ozawa,Osamu Onodera
Tetsutaro Ozawa
Multiple system atrophy (MSA) is an adult-onset neurodegenerative disorder that has both clinical and pathological variants. Clinical examples include MSA with predominant cerebellar ataxia (MSA-C) and MSA with predominant parkinsonism (MSA...
Rapid and coordinated processing of global motion images by local clusters of retinal ganglion cells [0.03%]
视网膜神经节细胞局部簇快速协同处理全局运动图像
Akihiro Matsumoto,Masao Tachibana
Akihiro Matsumoto
Even when the body is stationary, the whole retinal image is always in motion by fixational eye movements and saccades that move the eye between fixation points. Accumulating evidence indicates that the brain is equipped with specific mecha...