Shuntaro Hara
Shuntaro Hara
Non-steroidal anti-inflammatory drugs (NSAIDs) exert their anti-inflammatory and anti-tumor effects by reducing prostaglandin (PG) production via the inhibition of cyclooxygenase (COX). However, the gastrointestinal, renal and cardiovascula...
Makoto Murakami
Makoto Murakami
The phospholipase A2 (PLA2) family comprises a group of lipolytic enzymes that typically hydrolyze the sn-2 position of glycerophospholipids to give rise to fatty acids and lysophospholipids. The mammalian genome encodes more than 50 PLA2s ...
Significance of functional disease-causal/susceptible variants identified by whole-genome analyses for the understanding of human diseases [0.03%]
全基因组分析鉴定的功能疾病驱动/易感变异位点对理解人类疾病的意义
Yuki Hitomi,Katsushi Tokunaga
Yuki Hitomi
Human genome variation may cause differences in traits and disease risks. Disease-causal/susceptible genes and variants for both common and rare diseases can be detected by comprehensive whole-genome analyses, such as whole-genome sequencin...
New synthesis of a stereoisomeric mixture of methyl 12-trishomofarnesoate, a juvenile hormone mimic useful in sericulture by increasing silk production [0.03%]
一种新型的甲基十二角异芳酸三氢化物立体异构体混合物的合成：在蚕丝生产中提高蚕丝产量的保幼激素类似物
Kenji Mori
Kenji Mori
A mixture of (E,Z)-isomers of methyl 12-trishomofarnesoate (methyl 3,7,11-trimethyl-2,6,10-pentadecatrienoate), a juvenile hormone mimic, was synthesized in nine steps (32.6% overall yield) by starting from only four commercially available ...
Dynamic mechanisms driving conformational conversions of the β and ε subunits involved in rotational catalysis of F1-ATPase [0.03%]
F1-ATP酶旋转催化的β和ε亚基构象转换的动力学机制
Hideo Akutsu
Hideo Akutsu
F-type ATPase is a ubiquitous molecular motor. Investigations on thermophilic F1-ATPase and its subunits, β and ε, by NMR were reviewed. Using specific isotope labeling, pKa of the putative catalytic carboxylate in β was estimated. Segme...
Overcoming sleep disordered breathing and ensuring sufficient good sleep time for a healthy life expectancy [0.03%]
克服睡眠呼吸紊乱 确保充足优质睡眠时间以期健康长寿
Kazuo Chin
Kazuo Chin
Recent advances in basic and clinical medicine have resulted in major improvements in human health. Currently sleep has been considered an essential factor in maintaining and promoting a healthy life expectancy. Sleep disorders include more...
Treatment of rheumatoid arthritis with biological agents - as a typical and common immune-mediated inflammatory disease [0.03%]
生物制剂治疗类风湿关节炎——以典型常见自身免疫病论之
Tsutomu Takeuchi
Tsutomu Takeuchi
Molecules involved in the disease process facilitated our understanding of pathogenesis of the disease with unknown etiology such as immune-mediated and inflammatory diseases. Moreover, the targeted therapies against the proposed molecular ...
Tomohiro Watanabe,Naoki Asano,Masatoshi Kudo et al.
Tomohiro Watanabe et al.
Nucleotide-binding oligomerization domain 1 (NOD1) is an intracellular sensor that detects small peptides derived from the cell wall component of intestinal microflora. NOD1 is expressed in both non-hematopoietic cells such as epithelial ce...
Comprehensive functional genomics using Caenorhabditis elegans as a model organism [0.03%]
用线虫作为模型生物的全面功能基因组学研究
Shohei Mitani
Shohei Mitani
We have been working on functional genomics using C. elegans as a model organism. We first used cell-type specific markers and preexisting mutants to investigate how genotype-phenotype causal relationships are regulated. With the aid of tra...
Biological control for grapevine crown gall using nonpathogenic Rhizobium vitis strain ARK-1 [0.03%]
以非致病根瘤菌ARL-1控制葡萄癌肿病
Akira Kawaguchi,Koji Inoue,Koji Tanina et al.
Akira Kawaguchi et al.
Crown gall of grapevine, which is caused by tumorigenic Rhizobium vitis, is the most important bacterial disease of grapevine throughout the world. Screening tests of biological control agents resulted in the discovery of a nonpathogenic R....